@DCRnash We did this on old dual-GPU macs from the 2012-2015 era. We found they would switch from discrete to integrated GPU and load the system colorsbut not the f.lux ones.
On newer Apple Silicon macsthere is no switch (since there is just one GPU) and so we don't have to build a profile to keep things working. It's better in most cases for f.lux to be a "temporary" effect. But in case you somehow wanted the old behaviorit might still work with a pref - check out: https://justgetflux.com/news/2014/10/28/profile.html