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Upper Respiratory Infection (URI)

Medically Reviewed.Last updated on 02/28/2025.

Upper respiratory infections (URIs) are viruses and bacteria that infect your respiratory tract above your vocal cords. Symptoms can include a runny or stuffy nosesore throat or headache. Common coldsstrep throat and sinus infections are all examples of upper respiratory infections. Most URIs are caused by viruses and go away on their own.

What’s an Upper Respiratory Tract Infection?

Symptoms of upper respiratory infections include sore throatstuffy or runny nosecoughfeverfatigue and more
Upper respiratory infections can affect your nosesinusesthroat (pharynx) and voice box (larynx).

An upper respiratory infection (URI) is a viral or bacterial illness in the upper part of your respiratory system. This includes your nosesinuses and throat.

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A runny nosesore throatheadache and other cold-like symptoms might come to mind when you think of an upper respiratory infection. And it’s true — common colds and other viruses are usually to blame for URIs. But some URIslike strep throat or some cases of sinusitisare bacterial infections. Still otherslike the viruses responsible for the fluCOVID-19 and RSVcan cause both upper and lower respiratory infections.

Symptoms and Causes

What are the symptoms of an upper respiratory tract infection?

Symptoms of upper respiratory infections depend on the cause and what part of your body is affected. Infections can lead to swelling in parts of your respiratory tractcausing conditions like pharyngitislaryngitis and epiglottitiswhich can have different symptoms.

Symptoms of upper respiratory infections can include:

What causes upper respiratory tract infections?

Viruses cause most upper respiratory infections. But bacteria and even fungi can cause themtoo. Specific causes can include:

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Are upper respiratory infections contagious?

Yesthe viruses and bacteria that cause upper respiratory infections are contagious (spread from person to person). They can spread through:

  • Respiratory dropletswhen someone coughssneezes or talks
  • Sharing eating or drinking utensils (like forksspoonscups or water bottles)
  • Contact with objects or surfaces with germs on them (think doorknobslight switchesphones or toys)

Fungi that cause upper respiratory infections aren’t contagious.

What are the complications of upper respiratory tract infections?

Upper respiratory infections like colds rarely lead to complications. But URIs can sometimes cause inflammation in your lungsleading to pneumonia. Additionallyif bacterial or fungal infections are left untreatedthey can travel to other parts of your body and cause:

You might be at higher risk for complications from a URI if you have certain health conditions or a compromised immune systemor if you’re older than 65. Newborns are also at higher risk for severe illness.

Diagnosis and Tests

How are upper respiratory tract infections diagnosed?

Healthcare providers usually diagnose upper respiratory infections based on your symptoms and nasal swab or throat culture. If your symptoms are mild and your tests are negative for infections like the flu or strep throatyou might have one of hundreds of common cold viruseswhich providers don’t often test for.

Management and Treatment

How do you treat upper respiratory tract infections?

Treatment for upper respiratory infections depends on the cause. There aren’t any specific treatments for most viral URIslike colds. Providers treat bacterial infectionslike strep throatwith antibiotics.

Outlook / Prognosis

How can I get rid of an upper respiratory infection fast?

Most viral URIs have to run their course and go away on their own. They usually last one to two weeks. You can ease your symptoms by drinking plenty of water and taking over-the-counter medications.

If you have a bacterial infectionyour symptoms should start to improve a day or two after starting antibiotics. Don’t stop taking antibiotics even if you feel better — make sure you take the entire course as prescribed.

How long are you contagious with an upper respiratory infection?

Upper respiratory infections caused by viruses are usually most contagious in the first few days of symptomsand sometimesa day or two before they start. But you could still be contagious even when you start to feel betterespecially if you still have symptoms. Strep throat can be contagious for weeks if left untreated.

When should I see my healthcare provider?

Contact a healthcare provider if your symptoms:

  • Are severe
  • Last longer than two weeks
  • Come back frequently

Long-lasting or frequent symptoms could be signs of a bacterial infectionfungal infection or other health condition. Talk to your healthcare provider if you have a compromised immune system or other health condition that might put you at higher risk for severe illness if you get an URI.

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When should I go to the ER?

Go to the emergency room if you experience signs of severe illnessincluding:

Prevention

Can upper respiratory tract infections be prevented?

You can reduce your risk of getting or spreading upper respiratory infections by:

  • Getting all recommended vaccinations
  • Washing your hands frequently
  • Disinfecting surfaces
  • Not sharing foodutensils or cups
  • Wearing a mask if you must be around people when you’re sick

Additional Common Questions

Do you need antibiotics for an upper respiratory infection?

Most of the timeno. Antibiotics don’t work on virusesthe cause of most URIs. You only need antibiotics if your provider diagnoses you with a bacterial infectionlike strep throat.

A note from Cleveland Clinic

The sore throat. The stuffy head. The seemingly endless runny nose. We all know that familiar upper respiratory infection (URI) feeling. Fortunatelymost upper respiratory infections aren’t serious. But it doesn’t hurt to have a box of tissuesa humidifier and your favorite show or book at the ready for when one comes up. If you have any concerns about your symptomsor you think you could have a bacterial infectiontalk to a healthcare provider.

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Medically Reviewed.Last updated on 02/28/2025.

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References

Cleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracyreliability and up-to-date clinical standards.

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