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LDHA - lactate dehydrogenase A Gene

中文名称:乳酸脱氢酶 A

种属: Homo sapiens

同用名: LDHM; GSD11; PIG19; HEL-S-133P

基因 ID: 3939 | 基因类型: protein coding

关于 LDHA

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,394,563-18,408,425 (from NCBI)

This gene has 25 transcripts (splice variants)1 gene allele297 orthologues5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 177.1)liver (RPKM 154.8) and 25 other tissues.

功能概要

该基因编码的蛋白质在无氧糖酵解的最后一步催化 L-乳酸和 NAD 转化为丙酮酸和 NADH。该蛋白质主要存在于肌肉组织中,属于乳酸脱氢酶家族。该基因的突变与劳力性肌红蛋白尿有关。已发现该基因编码不同异构体的多个转录变体。人类基因组包含该基因的几个非转录假基因。[RefSeq 提供,2008 年 9 月]

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the Lactate Dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeqSep 2008]

LDHA 基因产物(5)

mRNA Protein Name
NM_001135239.2 NP_001128711.1 L-lactate dehydrogenase A chain isoform 2
NM_001165414.2 NP_001158886.1 L-lactate dehydrogenase A chain isoform 3
NM_001165415.2 NP_001158887.1 L-lactate dehydrogenase A chain isoform 4
NM_001165416.2 NP_001158888.1 L-lactate dehydrogenase A chain isoform 5
NM_005566.4 NP_005557.1 L-lactate dehydrogenase A chain isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-lactate dehydrogenase activity IMP
IMP: 通过突变表型推断
34381247 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lactate metabolic process IDA
IDA: 通过直接分析推断
24816116 GOA
involved in pyruvate metabolic process IDA
IDA: 通过直接分析推断
24816116 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of oxidoreductase complex IPI
IPI: 通过物理相互作用推断
24816116 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LDHA 蛋白结构

Ldh_1_N

Ldh_1_N: lactate/malate dehydrogenaseNAD binding domain (21 - 160)

Ldh_1_C

Ldh_1_C: lactate/malate dehydrogenasealpha/beta C-terminal domain (164 - 324)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
蛋白主名 其他名称

L-lactate dehydrogenase A chain

LDH muscle subunit

LDHA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LDHA P00338 LDHC Homo sapiens P07864 35271311
种属内
LDHA P00338 LDHC Homo sapiens P07864 28514442
种属内
LDHA P00338 LDHC Homo sapiens P07864 33961781
种属内
LDHA P00338 HSPA8 Homo sapiens P11142 23523103
种属内
LDHA P00338 HSPA8 Homo sapiens P11142 23523103
种属内
LDHA P00338 HSPA8 Homo sapiens P11142 23523103
种属内
LDHA P00338 LDHB Homo sapiens P07195 31515488
种属内
LDHA P00338 LDHB Homo sapiens P07195
Y2H
21988832
种属内
LDHA P00338 LDHB Homo sapiens P07195 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LDHA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70225 LDHA ProteinHuman (His) P00338-1 (M1-F332) ≥ 95%as determined by reducing SDS-PAGE.

LDHA 抗体

目录号 产品名 应用 反应物种
HY-P80422 Lactate Dehydrogenase Antibody (YA316) WBICC/IFIHC-PFCIP HumanMouse
HY-P80738 Lactate Dehydrogenase A Antibody (YA317) WBIHC-FIHC-PICC/IFIP HumanRat
HY-P80738A Lactate Dehydrogenase A Antibody (YA317)(PBS only) WBIHC-FIHC-PICC/IFIP HumanRat
HY-P80994 Lactate Dehydrogenase A Antibody (YA3482) WBIHC-FIHC-PICC/IFIP HumanMouseRat
HY-P80994A Lactate Dehydrogenase A Antibody (YA3482)(PBS only) WBIHC-FIHC-PICC/IFIP HumanMouseRat
HY-P86602 Lactate Dehydrogenase Antibody (YA6294) WBIHC-PICC/IFIPELISA HumanMouseRat
HY-P86628 Lactate Dehydrogenase Isoenzyme V Antibody (YA6320) WBIHC-PICC/IFIPELISA HumanMouseRat

关联疾病

疾病名称 别名
Fanconi-Bickel Syndrome

Glycogen Storage Disease Xi

Lactate Dehydrogenase A Deficiency

Hepatorenal Glycogenosis With Renal Fanconi Syndrome

Hepatic Glycogenosis With Amino Aciduria And Glucosuria

Fanconi Syndrome With Intestinal Malabsorption And Galactose Intolerance

Pseudo-Phlorizin Diabetes

Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency

FBS

Hepatic Glycogenosis With Fanconi Nephropathy

GSD11

Gsd Xi

Glycogen Storage Disease Due To Glut2 Deficiency

Glycogenosis Fanconi Type

Lactate Dehydrogenase Deficiency Type A

GlycogenosisFanconi Type

Fanconi Bickel Syndrome

Glut2 Deficiency

Gsd Due To Glut2 Deficiency

Glycogenosis Due To Glut2 Deficiency

Gsd Due To Lactate Dehydrogenase M-Subunit Deficiency

Glycogenosis Due To Lactate Dehydrogenase M-Subunit Deficiency

Ldh-M Subunit Deficiency

Glycogen Storage Disease 11

Storage DiseaseGlycogenType Xi

Glycogenosis With Glucoaminophosphaturia

Myoglobinuria
Leiomyomatosis
Hyperinsulinemic HypoglycemiaFamilial7

HHF7

Exercise-Induced Hyperinsulinemic Hypoglycemia

Exercise-Induced Hyperinsulinism

Familial Hyperinsulinemic Hypoglycemia 7

Eihi

Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency

Hyperinsulinism Due To Slc16a1 Deficiency

Hyperinsulinemic HypoglycemiaExercise-Induced

Exercise Induced Hyperinsulinemic Hypoglycemia

Hyperinsulinemic Hypoglycemia Exercise-Induced

Hyperinsulinemic Hypoglycemia Familial 7

Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage DiseaseGlycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic CarcinomaFamilial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic CarcinomaSomatic

Pancreatic CancerSomatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic CancerSusceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

CancerPancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt LymphomaSomatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant LymphomaBurkitt'S Type

Small Non-Cleaved Cell LymphomaBurkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

LymphomaSmall Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa 8Formerly

Rp8Formerly

Retinitis Pigmentosa 21Formerly

Rp21Formerly

Usher Syndrome

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast CancerFamilial

Malignant Neoplasm Of Breast

Breast CancerSusceptibility To

Breast CancerEarly-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast CancerInvasive Ductal

Breast CancerProtection Against

Breast CancerSomatic

Breast CancerMale

Breast CancerLobularSomatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast CancerMaleSusceptibility To

Breast CancerEarly-OnsetSusceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast CancerFamilial Male

Breast Male Carcinoma

Breast Neoplasms

Breast NeoplasmsMale

Mammary Tumors

Mammary Carcinomas

CancerBreast

CancerBreastSusceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Intrahepatic Gall Duct Cancer

Malignant Neoplasm Of Intrahepatic Bile Ducts

Malignant Neoplasm Of Intrahepatic Gall Duct

Ca Intrahepatic Bile Ducts

Malignant Neoplasm Of Intrahepatic Biliary Passages

Intrahepatic Bile Duct Carcinoma

Alzheimer Disease 13

AD13

Alzheimer Disease-13

Alzheimer'S Disease 13

Alzheimer'S Disease 13Late Onset

Esophagus Carcinoma In Situ

Carcinoma In Situ Of Esophagus

Carcinoma In Situ Of Oesophagus

Oesophagus Carcinoma In Situ

Severe Esophageal Dysplasia

Stage 0 Carcinoma Of The Esophagus

Stage 0 Carcinoma Of The Oesophagus

Severe Oesophageal Dysplasia

Stress Polycythemia

Gaisbock'S Syndrome

PolycythemiaEmotional

Pseudopolycythaemia

Gaisboeck'S Syndrome

Pseudopolycythemia

Gaisbock Syndrome

Stress Erythrocytosis

Pseudo-Polycythemia

Relative Erythrocytosis

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of LiverGallbladder And Bile Ducts

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal CancerSusceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal InstabilitySomatic

Colon CancerSomatic

Colon CancerSusceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal CancerSomatic

Colon CancerAdvancedSomatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

CancerColorectalSomatic

CancerColon

CancerColorectalSusceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Renal Cell CarcinomaNonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal CarcinomaChromophobeSomatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell CarcinomaSomatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

CarcinomaRenal Cell

Renal Cell CarcinomaClear CellSomatic

Renal Cell CarcinomaClear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

CarcinomaRenal CellNonpapillary

Amyotrophic Lateral Sclerosis 3

ALS3

Amyotrophic Lateral Sclerosis Type 3

Parkinson Disease 17

PARK17

Parkinson'S Disease 17

Autosomal Dominant Parkinson Disease 17

Parkinson DiseaseType 17

Combined Oxidative Phosphorylation Deficiency 33

COXPD33

Prolapse Of Urethra

Urethrocele

Prostate Cancer

Prostate Carcinoma

Prostate CancerFamilial

Prostate Neoplasm

Prostate CancerSomatic

Prostate CancerSusceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate CancerFamilialSusceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate CancerHereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

CancerProstate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LDHA RGD RGD:2996
Felis catus LDHA VGNC VGNC:81201
Mus musculus LDHA MGD MGI:96759
Others LDHA NCBI

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