汪志华，校聘教授，博士生导师，博士后合作导师。

研究方向：

1、疾病的靶点筛选及复杂中药作用靶点的确证

2、靶向药物高通量筛选及复杂中药成分鉴定

3、疾病的诊断预测模型及机制探索

电子邮箱：[email protected]

办公室：药学科学学院B513

教育经历：

2009/09- 2013/07，安徽医科大学，中药学专业，理学学士

2014/09- 2017/07，南开大学，生药学专业，理学硕士

2017/09 –2020/07，南开大学，化学生物学专业，理学博士

工作经历：

2020/07–2022/11，军事科学院军事医学研究院国家蛋白质科学中心（北京），博士后

2022/12–2025/11，中国科学技术大学生命科学与医学部，特任副研究员

2025/12–至今，安徽医科大学，药学科学学院，校聘教授

学术兼职：

2025/02，Global Burden of Disease（GBD）组织全球合作者

2025/04，《iMeta》、《iMetaOmics》、《iMetaMed》青年编委

2025/12，《iNewmedicine》青年编委

2026/01，《MedResearch》青年编委

科研项目：

1.安徽医科大学人才启动项目：2026.01-2030.12100万，主持

2.国家自然科学青年基金821028042022.01-2024.1230万元结题主持。

3.中国博士后基金面上项目2021MD703973，2021.01- 2022.128万元结题主持。

4.国家自然科学国际(地区)合作与交流项目817611680392018.01-2020.12200 万元结题参与。

5.国家自然科学基金委员会面上项目819734492020.01-2023.1255万元结题参与。

部分已发表文章：

（1）Zhihua Wang; Shuo Chen; Xiaojun Feng; Xi Chen; Paul C Evans; Hans Strijdom; Yu Ding; Jianping Weng and Suowen Xu. GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of MultimorbidityAdvanced science2025e10552. (Q1IF:14.1)

（2）Zhihua Wang; Shuo Chen; Fanshun Zhang; Shamil Akhmedov; Jianping Weng; Suowen Xu. Prioritization of lipid metabolism targets for the diagnosis and treatment of cardiovascular diseasesResearch20258(0618). (Q1IF:10.7)

（3） Juan Zhang#; Zhihua Wang#; Xingen Lin; Xiaoping Gao; Qiuping Wang; Rui Huang; Yaner Ruan; Haonan Xu; Lin Tian; Chen Ling; Ran Shi; Suowen Xu; Kong Chen; Yuen Wu. Mn–Ce Symbiosis: Nanozymes with Multiple Active Sites Facilitate Scavenging of Reactive Oxygen Species (ROS) Based on Electron Transfer and Confinement AnchoringAngewandte Chemie International Edition202426(e202416686). (Q1IF:16.9)

（4）Zhihua Wang; Miaomiao Wang; Mengxin Zhang; Kaikun Xu; Xinshuai Zhang; Yi Xie; Yiming Zhang; Cheng Chang; Xiaolu Li; Aihua Sun; Fuchu He. High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growthBMC medicine202220(1): 292. (Q1IF:11.5)

（5）Zhihua Wang; Wenbo Wu; Xiangchen Guan; Shuang Guo; Chaowen Li; Ruixue Niu; Jie Gao; Min Jiang; Liping Bai; Elaine Laihan Leung; Yuanyuan Hou; Zhihong Jiang; Gang Bai. 20(S)-Protopanaxatriol promotes the binding of P53 and DNA to regulate the antitumor network via multiomic analysisActa Pharmaceutica Sinica B202010(6): 1020-1035. (Q1IF:11.4)

（6）Zhihua Wang; Unchol Kim; Yanting Jiao; Chaowen Li; Yingying Guo; Xiaoyao Ma; Min Jiang; Zhihong Jiang; Yuanyuan Hou; Gang Bai. Quantitative Proteomics Combined with Affinity MS Revealed the Molecular Mechanism of Ginsenoside Antitumor EffectsJournal of Proteome Research201918(5): 2100-2108. (Q2IF:3.6)

（7）Zhihua Wang; Unchol Kim; Jinbiao Liu; Chuanjing Cheng; Wenbo Wu; Shuang Guo; Yunjiang Feng; Ronald J. Quinn; Yuanyuan Hou; Gang Bai. Comprehensive TCM molecular networking based on MS/MS in silico spectra with integration of virtual screening and affinity MS screening for discovering functional ligands from natural herbsAnalytical and Bioanalytical Chemistry2019411(22): 5785-5797. (Q2IF:3.8)

（8）Zhihua Wang#; Hao Liang#; Haijie Cao#; Bingjie Zhang; Jun Li; Wenqiong Wang; Shanshan Qin; Yuefei Wang; Lijiang Xuan; Luhua Lai; Wenqing Shui. Efficient ligand discovery from natural herbs by integrating virtual screeningaffinity mass spectrometry and targeted metabolomicsAnalyst2019144(9): 2881-2890. (Q2IF:4.0)

（9） Xiayun Ni#; Xiaojun Feng#; Zhihua Wang#; Yang Zhang; Peter J. Little; Yang Cao; Suowen Xu; Liqin Tang; Jian-ping Weng. Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathwayActa Pharmacologica Sinica202445(8): 1604-1617. (Q2IF:8.4)

（10） FuXu#; WangZhihua#; LiLixin; DongShishang; LiZhucui; JiangZhenzuo; WangYuefei; ShuiWenqing. Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics ApproachesSCIENTIFIC REPORTS20166(6): 29680. (Q3IF:4.1)

专利情况：

（1）贺福初; 孙爱华; 汪志华; 王苗苗; 王磊; 靶向SOAT1蛋白的化合物在制备预防和/或治疗肝癌药物中的应用2021-6-11中国CN 112933235 A。

（2）白钢; 侯媛媛; 汪志华 ; 一种靶向p53蛋白的寡核苷酸序列及其衍生探针和应用2020-7-30中国CN 111471686 A。

（3）水雯箐; 李利新; 汪志华; 付旭; 甘草次酸在抗埃博拉病毒药物中的应用2018-01-09中国CN 107550916 A。