Professor Denise Doolan
Professorial Research Fellow & Group Leader & Deputy Director (Research)
Institute for Molecular Bioscience
+61 7 334 62159
Researcher biography
Professor Denise Doolan is Director of Research at the Institute for Molecular Bioscience. She joined IMB in 2022 and was previously Deputy Director of the Australian Institute of Tropical Health and Medicineand Director of the JCU Centre for Molecular Therapeuticsat James Cook University.
She is a molecular immunologistworking on the development of vaccinesdiagnostics and host-directed therapeutics for infectious and chronic diseases that impact global public healthwith a particular focus on malaria. Her cross-disciplinary research program spans host-pathogen immunityantigen discoveryvaccine engineeringand biomarker discovery. A particular interest is the application of state-of-the-art genome-based technologies and human models of disease system to identify novel targets for intervention against disease or that predict risk of disease.
She is a recognized world expert in malaria immunologyvaccinologyand omic-based approaches for therapeutic and diagnostic development. She has been honoured as a Fellow of the International Society for Vaccines (2017) and a Fellow of the Australian Society of Parasitology (2019) in recognition of her leadership and contribution to health and medical science in Australia and internationally.
Professor Doolan serves on a number of Executive Boards and Advisory Boards. Most recentlyshe has been elected as President of the International Society for Vaccines (2021-2023)and has been appointed to the Federal Government's Australian Medical Research Advisory Board (AMRAB; 2021-2026) to provide specialist insights into Australia's medical research and innovation priorities.
Book Chapters
DriguezPatrickDoolanDenise L.MolinaDouglas M.LoukasAlexTrieuAngelaFelgnerPhil L. and McManusDonald P. (2015). Protein microarrays for parasite antigen discovery. Parasite genomics protocols . (pp. 221-33) edited by Christopher Peacock. ChamSwitzerland: Springer. doi: 10.1007/978-1-4939-1438-8_13
LoukasAlexGazeSorayaPearsonMarkDoolanDeniseFelgnerPhilipDiemertDavidMcmanusDonald P.DriguezPatrick and BethonyJeffrey (2012). Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates. Parasitic Helminths: TargetsScreensDrugs and Vaccines. (pp. 421-433) Wiley-VCH. doi: 10.1002/9783527652969.ch25
HedstromRichard C. and DoolanDenise L. (2002). DNA vaccination. Malaria methods and protocols. (pp. 347-59) edited by Denise L. Doolan. New YorkNYUnited States: Humana Press. doi: 10.1385/1-59259-271-6:347
DoolanDenise L. (2002). Assessing antigen-specific CD8+ CTL responses in humans. Malaria Methods and Protocols. (pp. 445-456) edited by Denise L. Doolan. New YorkNYUnited States: Humana Press. doi: 10.1385/1-59259-271-6:445
Journal Articles
SarathkumaraYomani D.KnuckeyKiara M.LutzkyViviana P.GrovesPenny L.TanMaxine E.ChambersDaniel C.ProiettiCarlaDoolanDenise L. and ApteSimon H. (2026). Proteome-wide serological profiling reveals broad elevation of EBV immunity in idiopathic pulmonary fibrosis. International Journal of Molecular Sciences27 (2) 7831-14. doi: 10.3390/ijms27020783
Bedsaul-FryerJacquelyn R.ProiettiCarlaOgwangMartin D.KerchanPatrickReynoldsSteven J.TengeConstance N.WerePamela A.TengeRobert K.WekesaWalter N.MasaluNestoryKawiraEstherKinyeraTobiasOtimIsaacNabalendeHadijahDhudhaHerryAyersLeona W.BhatiaKishorGoedertJames J.HongHyokyoung G.DoolanDenise and MbulaiteyeSam M. (2025). Abstract 60: Discovery of Epstein-Barr Virus Antibody Seroprofiles Associated with Burkitt Lymphoma Risk in East Africa. Cancer EpidemiologyBiomarkers & Prevention34 (12_Supplement)60-60. doi: 10.1158/1538-7755.asgcr25-abstract-60
SaggiomoSilvia LuizaBrowneDanielWongYideMilesJohn J.DoolanDeniseDalyNorelle L. and WilsonDavid Thomas (2025). When venom calms the storm: stonefish venoms suppress LPS-induced Th1 cytokine expression and secretion in human PBMCs. Toxicon267 108579108579. doi: 10.1016/j.toxicon.2025.108579
BrowneDaniel JCrooksPaulineSmithCorey and DoolanDenise L (2025). Differential reactivity of SARS ‐C oV ‐2 S‐protein T‐cell epitopes in vaccinated versus naturally infected individuals. Clinical & Translational Immunology14 (5) e70031e70031. doi: 10.1002/cti2.70031
BlakeJudith A.SeifertJuliaMiranda-HernandezSocorroRuscherRolandGiacominPaul R.DoolanDenise L. and KupzAndreas (2025). Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination. Mucosal Immunology18 (4)973-988. doi: 10.1016/j.mucimm.2025.05.007
SarathkumaraYomani D.Van BibberNathan W.LiuZhiweiHeslopHelen E.RouceRayne H.CoghillAnna ElizabethRooneyCliona M.ProiettiCarla and DoolanDenise L. (2025). Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas. Blood Advances9 (7)1658-1669. doi: 10.1182/bloodadvances.2024014937
JacksonSarah S.FrancisJuliaPfeifferRuth M.ProiettiCarlaCoghillAnna E.YuKelly J.SarathkumaraYomani D.HsuWan-LunArgirionIlonaWangCheng-PingChenChien-JenRothmanNathanielLanQingHildesheimAllanDoolanDenise L. and LiuZhiwei (2025). Sex differences in Anti–Epstein-Barr virus antibody responses. The Journal of Infectious Diseases232 (4)e671-e675. doi: 10.1093/infdis/jiaf067
MasseyLibbyGilroyJohnKowalEmmaDoolanDenise and CloughAlan (2024). Aboriginal families living with MJD in remote Australia: questions of access and equity. International Journal for Equity in Health23 (1) 1871. doi: 10.1186/s12939-024-02228-x
SarathkumaraYomani D.XianRena R.LiuZhiweiYuKelly J.ChanJohn K. C.KwongYok‐LamLamTai HingLiangRaymondChiuBrianXuJunHuWeiJiBu‐TianCoghillAnna E.KellyAshton M.PfeifferRuth M.RothmanNathanielAmbinderRichard F.HildesheimAllanLanQingProiettiCarla and DoolanDenise L. (2024). A proteome‐wide analysis unveils a core Epstein–Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations. International Journal of Cancer155 (8)1476-1486. doi: 10.1002/ijc.35072
BrowneDaniel J.MillerCatherine M.O'HaraEmily P.CourtneyRobertSeymourJamieDoolanDenise L. and OrrRyan (2024). Optimization and application of bacterial environmental DNA and RNA isolation for qualitative and quantitative studies. Environmental DNA6 (4) e5891-19. doi: 10.1002/edn3.589
BrowneDaniel J.MillerCatherine M. and DoolanDenise L. (2024). Technical pitfalls when collectingcryopreservingthawingand stimulating human T-cells. Frontiers in Immunology15 13821921-10. doi: 10.3389/fimmu.2024.1382192
BrowneDaniel J.KellyAshton M.BradyJamieProiettiCarlaSarathkumaraYomani D.PattinsonDavid J. and DoolanDenise L. (2023). Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria. Scientific Reports13 (1) 210711-11. doi: 10.1038/s41598-023-48066-9
ThanigaimaniShivshankarIyerVikramBingleyJohnBrowneDanielPhieJamesDoolanDenise and GolledgeJonathan (2023). Association of serum microRNAs with abdominal aortic aneurysm diagnosis and growth. European Journal of Vascular and Endovascular Surgery65 (4)573-581. doi: 10.1016/j.ejvs.2022.12.028
ArgirionIlonaPfeifferRuth M.ProiettiCarlaCoghillAnna E.YuKelly J.MiddeldorpJaap M.SarathkumaraYomani D.HsuWan-LunChienYin-ChuLouPei-JenWangCheng-PingRothmanNathanielLanQingChenChien-JenMbulaiteyeSam M.JarrettRuth F.GlimeliusIngridSmedbyKarin E.HjalgrimHenrikHildesheimAllanDoolanDenise L. and LiuZhiwei (2023). Comparative analysis of the humoral immune response to the EBV proteome across EBV-related malignancies. Cancer EpidemiologyBiomarkers and Prevention32 (5)OF1-OF10. doi: 10.1158/1055-9965.epi-22-0452
LamW K JackyKingAnn DMillerJacob ALiuZhiweiYuKelly JChuaMelvin L KMaBrigette B YChenMing YuanPinskyBenjamin ALouPei-JenWooJohn K SHsuWan-LunSimonJuliaDoolanDenise LWaterboerTimHuiEdwin PLiHuiTsangRaymond KWongKenneth C WGohJulian PVlantisAlexander CAiQi YongWongLun MAbdullahVictorLinJin ChingChenChien-JenPfeifferRuth MLeQuynh-ThuLeeAnne W M ... HildesheimAllan (2023). Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions. JNCI: Journal of the National Cancer Institute115 (4)355-364. doi: 10.1093/jnci/djad012
RatnatungaChampa N.TungattKatieProiettiCarlaHalstromSamHoltMichael R.LutzkyViviana P.PricePatriciaDoolanDenise L.BellScott C.FieldMatt A.KupzAndreasThomsonRachel M. and MilesJohn J. (2022). Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease. Frontiers in Immunology13 10477811-20. doi: 10.3389/fimmu.2022.1047781
RyanStephanie M.RuscherRolandJohnstonWayne A.PickeringDarren A.KennedyMalcolm W.SmithBrian O.JonesLindaBuitragoGeraldineFieldMatt A.EstermanAdrian J.McHughConnor P.BrowneDaniel J.CooperMartha M.RyanRachael Y MDoolanDenise L.EngwerdaChristian R.MilesKimMitrevaMakedonkaCroeseJohnRahmanTonyAlexandrovKirillGiacominPaul R. and LoukasAlex (2022). Novel antiinflammatory biologics shaped by parasite-host coevolution. Proceedings of the National Academy of Sciences of the United States of America119 (36) 22027951191-9. doi: 10.1073/pnas.2202795119
SarathkumaraYomani D.BrowneDaniel J.KellyAshton M.PattinsonDavid J.RushCatherine M.WarnerJeffreyProiettiCarla and DoolanDenise L. (2022). The effect of tropical temperatures on the quality of RNA extracted from stabilized whole-blood samples. International Journal of Molecular Sciences23 (18) 106091-15. doi: 10.3390/ijms231810609
BrowneDaniel J.KellyAshton M.BradyJamie L. and DoolanDenise L. (2022). A high-throughput screening RT-qPCR assay for quantifying surrogate markers of immunity from PBMCs. Frontiers in Immunology13 9622201-12. doi: 10.3389/fimmu.2022.962220
KarunathilakaAmaliHalstromSamuelPricePatriciaHoltMichaelLutzkyViviana P.DoolanDenise L.KupzAndreasBellScott C.ThomsonRachel M.MilesJohn J. and RatnatungaChampa N. (2022). CD161 expression defines new human γδ T cell subsets. Immunity and Ageing19 (1) 111-8. doi: 10.1186/s12979-022-00269-w
De SousaKarina P.PotriquetJeremyMulvennaJasonSotilloJavierGrovesPenny L.LoukasAlexApteSimon H. and DoolanDenise L. (2022). Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection. International Journal for Parasitology52 (1)35-45. doi: 10.1016/j.ijpara.2021.06.001
DoolanDeniseLuShanRossTed and CoxManon (2022). Meet the fellows: Everything about ISV. Human Vaccines and Immunotherapeutics18 (4) 2096964. doi: 10.1080/21645515.2022.2096964
CoghillAnna E.FangJianwenLiuZhiweiChenChien-JenJarrettRuth F.HjalgrimHenrikProiettiCarlaYuKelly J.HsuWan-LunLouPei-JenWangChen-PingZhaoYingdongDoolanDenise L. and HildesheimAllan (2022). Identifying Epstein-Barr virus peptide sequences associated with differential IgG antibody response. International Journal of Infectious Diseases11465-71. doi: 10.1016/j.ijid.2021.10.054
DoolanDenise L. (2021). Malaria research in Australia: looking through the lens of the past towards the future. International Journal for Parasitology51 (13-14)1255-1263. doi: 10.1016/j.ijpara.2021.11.005
LiuZhiweiSarathkumaraYomani D.ChanJohn K. C.KwongYok-LamLamTai HingIpDennis Kai MingChiuBrian C. -H.XuJunSuYu-ChiehProiettiCarlaCooperMartha M.YuKelly J.BassigBryanLiangRaymondHuWeiJiBu-TianCoghillAnna E.PfeifferRuth M.HildesheimAllanRothmanNathanielDoolanDenise L. and LanQing (2021). Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma. Scientific Reports11 (1) 236641-8. doi: 10.1038/s41598-021-02788-w
SelvaKevin J.van de SandtCarolien E.LemkeMelissa M.LeeChristina Y.ShoffnerSuzanne K.ChuaBrendon Y.DavisSamantha K.NguyenThi H. O.RowntreeLouise C.HensenLucaKoutsakosMariosWongChinn YiMordantFrancescaJacksonDavid C.FlanaganKatie L.CroweJaneTosifShidanNeelandMelanie R.SuttonPhilipLicciardiPaul V.CrawfordNigel W.ChengAllen C.DoolanDenise L.AmanatFatimaKrammerFlorianChappellKeithModhiranNaphakWattersonDanielYoungPaul ... ChungAmy W. (2021). Systems serology detects functionally distinct coronavirus antibody features in children and elderly. Nature Communications12 (1) 20372037. doi: 10.1038/s41467-021-22236-7
FulfordThomas S.VanHuyGherardinNicholas A.ZhengShuningCiulaMarcinDrummerHeidi E.RedmondSamuelTanHyon-XhiBooIreneCenterRob J.LiFanGrimleySamantha L.WinesBruce D.NguyenThi H. O.MordantFrancesca L.EllenbergPaulaRowntreeLouise C.KedzierskiLukaszChengAllen C.DoolanDenise L.MatthewsGailBondKatherineHogarthP. MarkMcQuiltenZoeSubbaraoKantaKedzierskaKatherineJunoJennifer A.WheatleyAdam K.KentStephen J. ... GodfreyDale (2021). A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2. EBioMedicine74 1037291-16. doi: 10.1016/j.ebiom.2021.103729
DoolanDenise L.KozlakidisZisisZhangZhonghengPaesslerSlobodanSuLongxiangYokotaYasuko TsunetsuguShiodaTatsuoRodriguez-PalaciosAlexanderKaynarAta MuratAhmedRukhsanaSamyAbdallahBradbyHannahKalergisAlexis M.DuttaMohan JyotiKogutMichael and ZhangShen-Ying (2021). Coronavirus Disease (COVID-19): Pathophysiologyepidemiologyclinical management and public health response. Frontiers in Public Health9 8071591-2. doi: 10.3389/fpubh.2021.807159
PearsonMark S.TedlaBemnet A.MekonnenGebeyaw G.ProiettiCarlaBeckerLukeNakajimaRieJasinskasAlDoolanDenise L.AmoahAbena S.KnoppStefanieRollinsonDavidAliSaid M.KaboleFatmaHokkeCornelis H.AdegnikaAkim A.FieldMatt A.van DamGovertCorstjensPaul L. A. M.MduluzaTakafiraMutapiFranciscaOeuvrayClaudeGrecoBeatriceChaiyadetSujittraLahaThewarachCaiPengfeiMcManusDonald P.BottazziMaria ElenaFelgnerPhilip L.SotilloJavier and LoukasAlex (2021). Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study. The Lancet Microbe2 (11)E617-E626. doi: 10.1016/s2666-5247(21)00150-6
WongYideMeehanMichael T.BurrowsScott R.DoolanDenise L. and MilesJohn J. (2021). Estimating the global burden of Epstein–Barr virus-related cancers. Journal of Cancer Research and Clinical Oncology148 (1)31-46. doi: 10.1007/s00432-021-03824-y
PooleJessicaHartley-TassellLauren E.DayChristopher J.StanisicDanielleGrovesPenny L.ChakravartySumanaSimB. Kim LeeHoffmanStephen L.TiralongoJoeBovinNicolaiDoolanDenise L. and JenningsMichael P. (2021). Identification of the Glycan binding profile of human and rodent Plasmodium sporozoites. ACS Infectious Diseases7 (8)2383-2389. doi: 10.1021/acsinfecdis.1c00084
NguyenThi H. O.RowntreeLouise C.PetersenJanChuaBrendon Y.HensenLucaKedzierskiLukaszvan de SandtCarolien E.ChaurasiaPriyankaTanHyon-XhiHabelJennifer R.ZhangWujiAllenLilith F.EarnestLindaMakKai YanJunoJennifer A.WraggKathleenMordantFrancesca L.AmanatFatimaKrammerFlorianMifsudNicole A.DoolanDenise L.FlanaganKatie L.SondaSabrinaKaurJasveenWakimLinda M.WestallGlen P.JamesFionaMouhtourisEffieGordonClaire L. ... KedzierskaKatherine (2021). CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity. Immunity54 (5)1066-1082+. doi: 10.1016/j.immuni.2021.04.009
KoutsakosMariosRowntreeLouise C.HensenLucaChuaBrendon Y.van de SandtCarolien E.HabelJennifer R.ZhangWujiJiaXiaoxiaoKedzierskiLukaszAshhurstThomas M.PutriGivanna H.Marsh-WakefieldFelixReadMark N.EdwardsDavis N.ClemensE. BridieWongChinn YiMordantFrancesca L.JunoJennifer A.AmanatFatimaAudsleyJenniferHolmesNatasha E.GordonClaire L.SmibertOlivia C.TrubianoJason A.HughesCarly M.CattonMikeDenholmJustin T.TongSteven Y. C.DoolanDenise L. ... KedzierskaKatherine (2021). Integrated immune dynamics define correlates of COVID-19 severity and antibody responses. Cell Reports Medicine2 (3) 1002081-21. doi: 10.1016/j.xcrm.2021.100208
HicksSarah M.PohlKaiNeemanTeresaMcNamaraHayley A.ParsonsKate M.HeJin-shuAliSidra A.NazirSaminaRowntreeLouise C.NguyenThi H. O.KedzierskaKatherineDoolanDenise L.VinuesaCarola G.CookMatthew C.CoatsworthNicholasMylesPaul S.KurthFlorianSanderLeif E.MannGraham J.GruenRussell L.GeorgeAmee J.GardinerElizabeth E. and CockburnIan A. (2021). A dual-antigen enzyme-linked immunosorbent assay allows the assessment of severe acute respiratory syndrome coronavirus 2 antibody seroprevalence in a low-transmission setting. Journal of Infectious Diseases223 (1)10-14. doi: 10.1093/infdis/jiaa623
RowntreeLouise C.ChuaBrendon Y.NicholsonSuellenKoutsakosMariosHensenLucaDourosCeliaSelvaKevinMordantFrancesca L.WongChinn YiHabelJennifer R.ZhangWujiJiaXiaoxiaoAllenLilyDoolanDenise L.JacksonDavid C.WheatleyAdam K.KentStephen J.AmanatFatimaKrammerFlorianSubbaraoKantaChengAllen C.ChungAmy W.CattonMikeNguyenThi H. O.van de SandtCarolien E. and KedzierskaKatherine (2021). Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features. Clinical and Translational Immunology10 (3) e12581-18. doi: 10.1002/cti2.1258
LoiseauClaireTraoreBoubacarOngoibaAissataKayentaoKassoumDoumboSafiatouDoumtabeDidierde SousaKarina P.BradyJamie L.ProiettiCarlaCromptonPeter D. and DoolanDenise L. (2021). Memory CD8+ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle-cell trait children. Clinical and Translational Immunology10 (3) e12651-12. doi: 10.1002/cti2.1265
PattinsonDavid J.ApteSimon H.WibowoNaniRivera-HernandezTaniaGrovesPenny L.MiddelbergAnton P. J. and DoolanDenise L. (2020). Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses. Frontiers in Immunology11 5646271-13. doi: 10.3389/fimmu.2020.564627
HabelJennifer R.NguyenThi H. O.van de SandtCarolien E.JunoJennifer A.ChaurasiaPriyankaWraggKathleenKoutsakosMariosHensenLucaJiaXiaoxiaoChuaBrendonZhangWujiTanHyon-XhiFlanaganKatie L.DoolanDenise L.TorresiJosephChenWeisanWakimLinda M.ChengAllen C.DohertyPeter C.PetersenJanRossjohnJamieWheatleyAdam K.KentStephen J.RowntreeLouise C. and KedzierskaKatherine (2020). Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype. Proceedings of the National Academy of Sciences of the United States of America117 (39)24384-24391. doi: 10.1073/pnas.2015486117
KifleDesalegn WoldeyohannesChaiyadetSujittraWaardenbergAshley J.WiseIngridCooperMarthaBeckerLukeDoolanDenise L.LahaThewarachSotilloJavierPearsonMark S. and LoukasAlex (2020). Uptake of Schistosoma mansoni extracellular vesicles by human endothelial and monocytic cell lines and impact on vascular endothelial cell gene expression. International Journal for Parasitology50 (9)685-696. doi: 10.1016/j.ijpara.2020.05.005
LiuZhiweiJarrettRuth FHjalgrimHenrikProiettiCarlaChangEllen T.SmedbyKarin E.YuKelly J.LakeAnnetteTroySallyMcAulayKaren A.PfeifferRuth M.AdamiHans-OlovGlimeliusBengtMelbyeMadsHildesheimAllanDoolanDenise L. and CoghillAnna E. (2020). Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma. International Journal of Cancer147 (3)608-618. doi: 10.1002/ijc.32741
CoghillAnna E.PfeifferRuth M.ProiettiCarlaHsuWan-LunChienYin-ChuLekieffreLeaKrauseLutzTengAndyPabloJocelynYuKelly J.LouPei-JenWangCheng-PingLiuZhiweiChenChien-JenMiddeldorpJaapMulvennaJasonBethonyJeffHildesheimAllan and DoolanDenise L. (2020). Erratum: Correction: Identification of a NovelEBV-based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan (Clinical cancer research : an official journal of the American Association for Cancer Research (2018) 24 6 (1305-1314)). Clinical Cancer Research26 (13)3496-3496. doi: 10.1158/1078-0432.CCR-20-1828
KaushanskyAlexisSibleyCarolMcFaddenGeoffCharmanSusanDoolanDeniseGoodMichaelFlanneryErikaHealerJulieDuffyMichaelTaylorTerrieCraigAlisterTilleyLeann and GilsonPaul (2020). Trends Talk MAM 2020: Growing Strong on the 20th Anniversary. Trends in Parasitology36 (6)487-494. doi: 10.1016/j.pt.2020.04.001
SimonJuliaLiuZhiweiBrennerNicoleYuKelly J.HsuWan-LunWangCheng-PingChienYin-ChuCoghillAnna E.ChenChien-JenButtJuliaProiettiCarlaDoolanDenise L.HildesheimAllan and WaterboerTim (2020). Validation of an Epstein-Barr virus antibody risk stratification signature for nasopharyngeal carcinoma by use of multiplex serology. Journal of Clinical Microbiology58 (5) e00077-201-9. doi: 10.1128/JCM.00077-20
LongleyRhea J.WhiteMichael T.TakashimaEizoBrewsterJessicaMoritaMasayukiHarbersMatthiasObadiaThomasRobinsonLeanne J.MatsuuraFumieLiuZoe S. J.Li-Wai-SuenConnie S. N.ThamWai-HongHealerJulieHuonChristeleChitnisChetan E.NguitragoolWangMonteiroWueltonProiettiCarlaDoolanDenise L.SiqueiraAndre M.DingXavier C.GonzalezIveth J.KazuraJamesLacerdaMarcusSattabongkotJetsumonTsuboiTakafumi and MuellerIvo (2020). Development and validation of serological markers for detecting recent Plasmodium vivax infection. Nature Medicine26 (5)741-749+. doi: 10.1038/s41591-020-0841-4
LoiseauClaireDoumboOgobara K.TraoreBoubacarBradyJamie L.ProiettiCarlaSousaKarina P.CromptonPeter D. and DoolanDenise L. (2020). A novel population of memory‐activated natural killer cells associated with low parasitaemia in Plasmodium falciparum ‐exposed sickle‐cell trait children. Clinical and Translational Immunology9 (4) e1125e1125. doi: 10.1002/cti2.1125
BrowneDaniel J.BradyJamie L.WaardenbergAshley J.LoiseauClaire and DoolanDenise L. (2020). An analytically and diagnostically sensitive RNA extraction and RT-qPCR protocol for peripheral blood mononuclear cells. Frontiers in Immunology11 4021-15. doi: 10.3389/fimmu.2020.00402
RatnatungaChampa N.LutzkyViviana P.KupzAndreasDoolanDenise L.ReidDavid W.FieldMatthewBellScott C.ThomsonRachel M. and MilesJohn J. (2020). The rise of non-tuberculosis mycobacterial lung disease. Frontiers in Immunology11 303303. doi: 10.3389/fimmu.2020.00303
ApteSimon HMinigoGabrielaGrovesPenny LSpargoJessie CPlebanskiMagdalenaGriggMatthew JKenangalemEnnyBurelJulie GLoughlandJessica RFlanaganKatie LPieraKim AWilliamTimothyPriceRic NWoodberryToniaBarberBridget EAnsteyNicholas M and DoolanDenise L (2020). A population of CD4hi CD38hi T cells correlates with disease severity in patients with acute malaria. Clinical and Translational Immunology9 (11) e12091-18. doi: 10.1002/cti2.1209
LoiseauClaireCooperMartha M. and DoolanDenise L. (2020). Deciphering host immunity to malaria using systems immunology. Immunological Reviews293 (1)115-143. doi: 10.1111/imr.12814
ProiettiCarlaKrauseLutzTrieuAngelaDodooDanielGyanBenKoramKwadwo A.RogersWilliam O.RichieThomas L.CromptonPeter D.FelgnerPhilip L. and DoolanDenise L. (2020). Immune signature against Plasmodium falciparum antigens predicts clinical immunity in distinct malaria endemic communities. Molecular and Cellular Proteomics19 (1)101-113. doi: 10.1074/mcp.RA118.001256
CoghillAnna E.ProiettiCarlaLiuZhiweiKrauseLutzBethonyJeffProkunina-OlssonLudmilaObajemuAdeolaNkrumahFrancisBiggarRobert J.BhatiaKishorHildesheimAllanDoolanDenise L. and MbulaiteyeSam M. (2020). The association between the comprehensive Epstein–Barr virus serologic profile and endemic Burkitt lymphoma. Cancer Epidemiology Biomarkers and Prevention29 (1)57-62. doi: 10.1158/1055-9965.EPI-19-0551
TessemaSofonias K.NakajimaRieJasinskasAlgisMonkStephanie L.LekieffreLeaLinEnmooreKiniboroBensonProiettiCarlaSibaPeterFelgnerPhilip L.DoolanDenise L.MuellerIvo and BarryAlyssa E. (2019). Protective immunity against severe malaria in children is associated with a limited repertoire of antibodies to conserved PfEMP1 variants. Cell Host & Microbe26 (5)579-590+. doi: 10.1016/j.chom.2019.10.012
LiuZhiweiYuKelly J.CoghillAnna E.BrennerNicoleCaoSu-MeiChenChien-JenChenYufengDoolanDenise L.HsuWan-LunLaboNazzarenaMiddeldorpJaap M.MileyWendellSimonJuliaWangCheng-PingWaterboerTimWhitbyDeniseXieShang-HangYeWeimin and HildesheimAllan (2019). Multilaboratory assessment of Epstein-Barr virus serologic assays: the case for standardization. Journal of Clinical Microbiology57 (11) e01107-191-8. doi: 10.1128/JCM.01107-19
CooperMartha M.LoiseauClaire and DoolanDenise L. (2019). Casting a wide net around immunity to malaria catches p53. Immunity51 (4)603-605. doi: 10.1016/j.immuni.2019.09.011
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SedegahMarthaTammingaCindyMcGrathShannonHouseBrentGaneshanHariniLejanoJennylynnAbotEstebanBananiaGlenna JSayoRenatoFarooqFouziaBelmonteMariaManoharNaliniRichieNancy OWoodChloeLongCarole ARegisDavidWilliamsFrancis TShiMengChuangIlinSpringMicheleEpsteinJudith EMendoza-SilveirasJoseLimbachKeithPattersonNoelle BBruderJoseph TDoolanDenise LKingC RichterSoissonLorraineDiggsCarter ... RichieThomas L (2011). Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults. PLoS One6 (10) e245861-22. doi: 10.1371/journal.pone.0024586
ApteSimon H.GrovesPenny L.RoddickJoanne S.P da HoraVanusa and DoolanDenise L. (2011). High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood. International Journal for Parasitology41 (12)1285-94. doi: 10.1016/j.ijpara.2011.07.010
TrieuAngelaKayalaMatthew A.BurkChadMolinaDouglas M.FreilichDaniel A.RichieThomas L.BaldiPierreFelgnerPhilip L. and DoolanDenise L. (2011). Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens. Molecular and Cellular Proteomics10 (9) M111.0079481-15. doi: 10.1074/mcp.M111.007948
LoukasAlexGazeSorayaMulvennaJason P.GasserRobin BBrindleyPaul J.DoolanDenise L.BethonyJeffrey M.JonesMalcolm K.GobertGeoffrey N.DriguezPatrickMcManusDonald P. and HotezPeter J. (2011). Vaccinomics for the major blood feeding helminths of humans. OMICS: A Journal of Integrative Biology15 (9)567-577. doi: 10.1089/omi.2010.0150
CampoJoseph J.WhitmanTimothy J.FreilichDanielBurgessTimothy H.MartinGregory J. and DoolanDenise L. (2011). Toward a surrogate marker of malaria exposure: Modeling longitudinal antibody measurements under outbreak conditions. PLoS One6 (7) e218261-6. doi: 10.1371/journal.pone.0021826
DodooDanielHollingdaleMichael R.AnumDorothyKoramKwadwo A.GyanBenAkanmoriBartholomew D.OcranJosephineAdu-AmankwahSusanGeneshanHariniAbotEstebanLeganoJennylynBananiaGlennaSayoRenatoBrambillaDonaldKumarSanjaiDoolanDenise L.RogersWilliam O.EpsteinJudithRichieThomas L. and SedegahMartha (2011). Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults. Malaria Journal10 (1) 168. doi: 10.1186/1475-2875-10-168
DouradinhaBruno and DoolanDenise L. (2011). Harnessing immune responses against Plasmodium for rational vaccine design. Trends in Parasitology27 (6)274-283. doi: 10.1016/j.pt.2011.01.002
da HoraVanusa P.ConceiçãoFabricio R.DellagostinOdir A. and DoolanDenise L. (2011). Non-toxic derivatives of LT as potent adjuvants. Vaccine29 (8)1538-1544. doi: 10.1016/j.vaccine.2010.11.091
DoolanDenise L. (2011). Plasmodium immunomics. International Journal for Parasitology41 (1)3-20. doi: 10.1016/j.ijpara.2010.08.002
GoodMichael F. and DoolanDenise L. (2010). Malaria vaccine design: Immunological Considerations. Immunity33 (4)555-566. doi: 10.1016/j.immuni.2010.10.005
SedegahMarthaKimYohanPetersBjoernMcGrathShannonGaneshanHariniLejanoJennylynnAbotEstebanBananiaGlennaBelmonteMariaSayoRenatoFarooqFouziaDoolanDenise L.RegisDavidTammingaCindyChuangIlinBruderJoseph T.KingC. RichterOckenhouseChristian F.FaberBartRemarqueEdmondHollingdaleMichael R.RichieThomas L. and SetteAlessandro (2010). Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein. Malaria Journal9 (1) 241. doi: 10.1186/1475-2875-9-241
RedmondA. M. and DoolanD. L. (2010). The Australasian contribution to malaria vaccine development. Parasite Immunology32 (8)607-622. doi: 10.1111/j.1365-3024.2010.01229.x
ApteSimon HGrovesPennyOlverStuartBazAdrianaDoolanDenise LKelsoAnne and KienzleNorbert (2010). IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response. Journal of Immunology185 (2)998-1004. doi: 10.4049/jimmunol.0903372
BruderJoseph T.StefaniakMaureen E.PattersonNoelle B.ChenPingKonovalovaSvetlanaLimbachKeithCampoJoseph J.EttyreddyDamodarLiShengDubovskyFilipRichieThomas L.KingC. RichterLongCarole A. and DoolanDenise L. (2010). Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth. Vaccine28 (18)3201-3210. doi: 10.1016/j.vaccine.2010.02.024
CromptonPeter D.KayalaMatthew A.TraoreBoubacarKayentaoKassoumOngoibaAissataWeissGreta E.MolinaDouglas M.BurkChad R.WaisbergMichaelJasinskasAlgisTanXiaolinDoumboSafiatouDoumtabeDidierKoneYounoussouNarumDavid L.LiangXiaowuDoumboOgobara K.MillerLouis H.DoolanDenise L.BaldiPierreFelgnerPhilip L. and PierceSusan K. (2010). A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proceedings of the National Academy of Sciences of the United States of America107 (15)6958-6963. doi: 10.1073/pnas.1001323107
SedegahMarthaRogersWilliam O.BelmonteMariaBelmonteArnelBananiaGlennaPattersonNoelle B.RusalovDenisFerrariMarilynRichieThomas L. and DoolanDenise L. (2010). Vaxfectin® enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses. Vaccine28 (17)3055-3065. doi: 10.1016/j.vaccine.2009.10.044
DoolanDenise L. (2010). Special issue on malaria vaccine development. Human Vaccines6 (1). doi: 10.4161/hv.6.1.10703
JiangGeorgeShiMengContehSolomonRichieNancyBananiaGlennaGeneshanHariniValenciaAnaisSinghPritiAguiarJoaoLimbachKeithKamrudKurt I.RaynerJonathanSmithJonathanBruderJoseph T.KingC. RichterTsuboiTakafumiTakeoSatoruEndoYaetaDoolanDenise L.RichieThomas L. and WeissWalter R. (2009). Sterile protection ,against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: Comparison of heterologous prime boost strategies. PloS one4 (8) e6559e6559 -1-e6559 -12. doi: 10.1371/journal.pone.0006559
WoodberryToniaPinzon-CharryAlbertoPieraKim A.PanpisutchaiYawalakEngwerdaChristian R.DoolanDenise L.SalwatiErviKenangalemEnnyTjitraEmilianaPriceRic N.GoodMichael F. and AnsteyNicholas M. (2009). Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria. Malaria Journal8 (1) 122122.1-122.10. doi: 10.1186/1475-2875-8-122
DobañoaCarlotaSedegahMarthaRogersWilliam O.KumarSanjaiZhengHongHoffmanStephen L. and DoolanDenise (2009). Plasmodium: Mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity. Experimental Parasitology122 (2)112-123. doi: 10.1016/j.exppara.2009.02.010
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DoolanDenise L.DobanoCarlota and BairdJ. Kevin (2009). Acquired immunity to malaria. Clinical Microbiology Reviews22 (1)13-26. doi: 10.1128/CMR.00025-08
DoolanDenise L.MuYunxiangUnaBerkaySundareshSumanHirstSiddiquaValdezConrad and et al. (2008). Profiling humoral immune responses to P. falciparum infection with protein microarrays. Proteomics8 (22)4680-4694. doi: 10.1002/pmic.200800194
DoolanDenise L. (2008). The path of discovery. Human Vaccines4 (5)324-327. doi: 10.4161/hv.4.5.6707
RegisDavid P.DobañoCarlotaQuiñones-OlsonPaolaLiangXiaowuGraberNorma L.StefaniakMaureen E.CampoJoseph J.CarucciDaniel J.RothDavid A.HeHuapingFelgnerPhilip L. and DoolanDenise L. (2008). Transcriptionally active PCR for antigen identification and vaccine development: In vitro genome-wide screening and in vivo immunogenicity. Molecular and Biochemical Parasitology158 (1)32-45. doi: 10.1016/j.molbiopara.2007.11.009
DoolanDenise L. and StewartV. Ann (2007). Status of malaria vaccine R&D in 2007. Expert Review of Vaccines6 (6)903-905. doi: 10.1586/14760584.6.6.903
JiangGeorgeCharoenvitYupinMorenoAlbertoBaracerosMaria F.BananiaGlennaRichieNancyAbotSteveGaneshanHariniFallarmeVictoriaPattersonNoelle B.GeallAndrewWeissWalter R.StrobertElizabethCaro-AquilarIvetteLanarDavid E.SaulAllanMartinLaura B.GowdaKalpanaMorrissetteCraig R.KaslowDavid C.CarucciDaniel J.GalinskiMary R. and DoolanDenise L. (2007). Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeysin the absence of antigen interferencewith heterologous DNA prime/poxvirus boost immunization. Malaria Journal6 (1) 135135-152. doi: 10.1186/1475-2875-6-135
BriceGary T.DobanoCarlotaSedegahMarthaStefaniakMaureenGraberNorma L.CampoJoseph J.CarucciDaniel J. and DoolanDenise L. (2007). Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines. Microbes and Infection9 (12-13)1439-1446. doi: 10.1016/j.micinf.2007.07.009
DobanoCarlotaWideraGeorgRabussayDietmar and DoolanDenise L. (2007). Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation. Vaccine25 (36)6635-6645. doi: 10.1016/j.vaccine.2007.06.036
DobañoaCarlotaRogersaWilliam O.Gowdaa Kalpana and DoolanaDenise L. (2007). Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines. Immunology Letters111 (2)92-102. doi: 10.1016/j.imlet.2007.05.007
LiShengqiangLockeEmilyBruderJosephClarkeDavidDoolanDenise L.HavengaMenzo J. E.HillAdrian V. S.LiljestromPeterMonathThomas P.NaimiHussein Y.OckenhouseChristianTangDe-chu C.Van KampenKent R.ViretJean-FrancoisZavalaFidel and DubovskyFilip (2007). Viral vectors for malaria vaccine development. Vaccine25 (14)2567-2574. doi: 10.1016/j.vaccine.2006.07.035
DobanoC.McTagueA.SetteA.HoffmanS. L.RogersW. O. and DoolanD. L. (2007). Mutating the Anchor Residues Associated with MHC Binding Inhibits and Deviates CD8+ T cell Mediated Protective Immunity Against Malaria. Molecular Immunology44 (9)2235-2248. doi: 10.1016/j.molimm.2006.11.003
GoodMichael F. and DoolanDenise L. (2007). Malaria's journey through the lymph node. Nature Medicine13 (9)1023-1024. doi: 10.1038/nm0907-1015
DobanoC. and DoolanD.L. (2007). Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17 kDa. Molecular Immunology44 (11)3037-3048. doi: 10.1016/j.molimm.2007.01.001
SedegahMarthaRogersWilliam O.BelmonteArnelBelmonteMariaBananiaGlennaPattersonNoelleFerrariMarilynKaslowDavid C.CarucciDaniel J.RichieThomas L. and DoolanDenise L. (2006). Vaxfectin™ enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccine. Vaccine24 (11)1921-1927. doi: 10.1016/j.vaccine.2005.10.041
DoolanDenise L.FreilichDaniel A.BriceGary T.BurgessTimothy H.BerzinsMara P.BullRobert L.GraberNorma L.DabbsJason L.ShatneyLori L.BlazesDavid L.BebrisLolita M.MaloneMaria F.EisoldJohn F.MateczunAlfred J. and MartinGregory J. (2006). The US capitol bioterrorism anthrax exposures: Clinical epidemiological and immunological characteristics. Journal of Infectious Diseases195 (2)174-184. doi: 10.1086/510312
DoolanD. L. and Martinez-AlierN. (2006). Immune response to pre-erythrocytic stages of malaria parasites. Current Molecular Medicine6 (2)169-185. doi: 10.2174/156652406776055249
SundareshS.DoolanD. L.HirstS.MuY.UnalB.DaviesH.FelgnerP. and BaldiP. (2006). Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques. Bioinformatics22 (14)1760-1766. doi: 10.1093/bioinformatics/btl162
CharoenvitYupinBriceGary T.BaconDavidMajamVictoriaWilliamsJackieAbotEstebanGaneshanHariniSedegahMarthaDoolanDenise L.CarucciDaniel J. and ZimmermanDaniel H. (2004). A Small Peptide (CEL-1000) Derived from the ß-Chain of the Human Major Histocompatibility Complex Class II Molecule Induces Complete Protection against Malaria in an Antigen-Independent Manner. Antimicrobial agents and chemotherapy48 (7)2455-2463. doi: 10.1128/AAC.48.7.2455-2463.2004
WangRuobingEpsteinJudithCharoenvitYupinBaracerosFe MariaRahardjoNancyGayTanyaBananiaJo-GlennaChattopadhyayRanade la VegaPatriciaRichieThomas L.TornieporthNadiaDoolanDenise L.KesterKent E.HeppnerD. GrayNormanJonCarucciDaniel J.CohenJoe D. and HoffmanStephen L. (2004). Induction in Humans of CD8+ and CD4+ T Cell and Antibody Responses by Sequential Immunization with Malaria DNA and Recombinant Protein. Journal of immunology172 (9)5561-5569. doi: 10.4049/jimmunol.172.9.5561
DoolanD. L.AguiarJ. C.WeissW. R.SetteA.FelgnerP. L.RegisD. P.Quinones-CasasP.YatesJ. R. IIIBlairP. L.RichieT. L.HoffmanS. L. and CarucciD. J. (2003). Utilization of genomic sequence information to develop malaria vaccines. Journal of experimental biology206 (21)3789-3802. doi: 10.1242/jeb.00615
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GramzinskiRobert A.DoolanDenise L.SedegahMarthaDavisHeather L.KriegArthur M. and HoffmanStephen L. (2002). Erratum: Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice (Infection and Immunity (2001) 69:3 (1643-1649)). Infection and Immunity70 (9). doi: 10.1128/IAI.70.9.5338.2002
SedegahMarthaBriceGary T.RogersWilliam O.DoolanDenise L.CharoenvitYupinJonesTrevor R.MajamVictoria F.BelmonteArnelLuMinhBelmonteMariaCarucciDaniel J. and HoffmanStephen L. (2002). Persistence of Protective Immunity to Malaria Induced by DNA Priming and Poxvirus Boosting: Characterization of Effector and Memory CD8+-T-Cell Populations. Infection and immunity70 (7)3493-3499. doi: 10.1128/IAI.70.7.3493-3499.2002
HoffmanStephen L.GohLucy M. L.LukeThomas C.SchneiderImogeneLeThong P.DoolanDenise L.SacciJohnDe la VegaPatriciaDowlerMeganPaulChrisGordonDaniel M.StouteJose A.Preston ChurchL. W.SedegahMarthaGray HeppnerD.Ripley BallouW. and RichieThomas L. (2002). Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. Journal of Infectious Diseases185 (8)1155-1164. doi: 10.1086/339409
DoolanDenise L. and HoffmanStephen L. (2002). Nucleic acid vaccines against malaria. Chemical Immunology80308-321. doi: 10.1159/000058851
DoolanD. L.CoppelR. L. and WatersA. P. (2001). Foreword--MBP thematic issue on genomics. Molecular and Biochemical Parasitology118 (2)127-8. doi: 10.1016/s0166-6851(01)00389-9
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BriceG. T.GraberN. L.HoffmanS. L. and DoolanD. L. (2001). Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specificgenetically restricted IFN-γ production and IFN-γ-secreting cells. Journal of Immunological Methods257 (1-2)55-69. doi: 10.1016/s0022-1759(01)00446-x
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HoffmanStephen L. and DoolanDenise L. (2000). Malaria vaccines-targeting infected hepatocytes. Nature Medicine6 (11)1218-1219. doi: 10.1038/81315
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DoolanDenise L. and HoffmanStephen L. (2000). The complexity of protective immunity against liver-stage malaria. Journal of Immunology165 (3)1453-1462. doi: 10.4049/jimmunol.165.3.1453
DoolanDenise L.SouthwoodScottChesnutRobertAppellaEttoreGomezEduardoRichardsAllenHigashimotoYuichiro I.MaewalAjeshSidneyJohnGramzinskiRobert A.MasonCarlKoechDavyHoffmanStephen L. and SetteAlessandro (2000). HLA-DR-promiscuous T cell epitopes frown Plasmodium falciparum pre- erythrocytic-stage antigens restricted by multiple HLA class II alleles. Journal of Immunology165 (2)1123-1137. doi: 10.4049/jimmunol.165.2.1123
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DoolanDenise L.HoffmanStephen L.SouthwoodScottWentworthPeggy A.SidneyJohnChesnutRobert W.KeoghElissaAppellaEttoreNutmanThomas B.LalAltafGordonDaniel M.OlooAggrey and SetteAlessandro (1997). Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles. Immunity7 (1)97-112. doi: 10.1016/S1074-7613(00)80513-0
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DoolanDenise L.SedegahMarthaHedstromRichard C.AguiarJoao C. and HoffmanStephen L. (1996). DNA vaccination against malaria. Advanced Drug Delivery Reviews21 (1)49-61. doi: 10.1016/0169-409X(96)00018-X
DoolanD. L.HedstromR. C.RogersW. O.CharoenvitY.RogersM.de la VegaP. and HoffmanS. L. (1996). Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoeliihomolog of Plasmodium falciparum exported protein 1. The Journal of Biological Chemistry271 (30)17861-17868. doi: 10.1074/jbc.271.30.17861
DoolanD. L.SedegahM.HedstromR. C.HobartP.CharoenvitY. and HoffmanS. L. (1996). Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-interferon gamma-and nitric oxide-dependent immunity. The Journal of Experimental Medicine183 (4)1739-1746. doi: 10.1084/jem.183.4.1739
GardnerMalcolm J.DoolanDenise L.HedstromRichard C.WangRuobingSedegahMarthaGramzinskiRobert A.AguiarJoao C.WangHelenMargalithMichalHobartPeter and HoffmanStephen L. (1996). DNA vaccines against malaria: Immunogenicity and protection in a rodent model. Journal of Pharmaceutical Sciences85 (12)1294-1300. doi: 10.1021/960147h
HOFFMANS. L.DOOLAND. L.SEDEGAHM.GRAMZINSKIR.WANGH.GOWDAK.HOBARTP.MARGALITHM.NORMANJ. and HEDSTROMR. C. (1995). Nucleic Acid Malaria Vaccines: Current Status and Potential. Annals of the New York Academy of Sciences772 (1)88-94. doi: 10.1111/j.1749-6632.1995.tb44734.x
ArgaetV PSchmidtC WBurrowsS RSilinsS LKurillaM GDoolanD LSuhrbierAMossD JKieffESculleyT B and MiskoI S (1994). Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. The Journal of Experimental Medicine180 (6)2335-2340. doi: 10.1084/jem.180.6.2335
DoolanD. L.BeckH. P. and GoodM. F. (1994). Evidence for limited activation of distinct CD4+ T cell subsets in response to the Plasmodium falciparum circumsporozoite protein in Papua New Guinea. Parasite Immunology16 (3)129-136. doi: 10.1111/j.1365-3024.1994.tb00332.x
DoolanD. L.KhamboonruangC.BeckH. P.HoughtenR. A. and GoodM. F. (1993). Cytotoxic T lymphocyte (CTL) low-responsiveness to the Plasmodium falciparum circumsporozoite protein in naturally-exposed endemic populations: analysis of human CTL response to most known variants. International Immunology5 (1)37-46. doi: 10.1093/intimm/5.1.37
DoolanD. L. and GoodM. F. (1993). Developing a malaria sporozoite vaccine. Today's Life Science5 (6)18-27.
DoolanD. L.SaulA. J. and GoodM. F. (1992). Geographically restricted heterogeneity of the Plasmodium falciparum circumsporozoite protein: relevance for vaccine development. Infection and Immunity60 (2)675-682. doi: 10.1128/iai.60.2.675-682.1992
DoolanD. L. and GoodM. F. (1992). Plasmodium falciparum CS protein--prime malaria vaccine candidate: definition of the human CTL domain and analysis of its variation. Memorias do Instituto Oswaldo Cruz87 Suppl 3241-247. doi: 10.1590/s0074-02761992000700040
DoolanD. L.HoughtenR. A. and GoodM. F. (1991). Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein. International Immunology3 (6)511-516. doi: 10.1093/intimm/3.6.511
DoolanD. L.HoughtenR. A. and GoodM. F. (1991). Assessment of human cytotoxic T cell activity using synthetic peptides: potential for field application. Peptide Research4 (3)125-131.
WalkerP. J.ByrneK. A.CybinskiD. H.DoolanD. L. and WangY. H. (1991). Proteins of bovine ephemeral fever virus. Journal of General Virology72 ( Pt 1) (1)67-74. doi: 10.1099/0022-1317-72-1-67
DoolanD. L. and WardL. C. (1987). Amino acid supply and protein metabolism in Ehrlich ascites tumour cells. 2 Incorporation of 14C-tyrosine. Cytobios50 (204)49-61.
DoolanDL and WardLC (1987). Amino-Acid Supply and Protein-Metabolism in Ehrlich Ascites Tumor-Cells .1. Identification of Limiting Amino-Acids. Cytobios51 (204)7-23.
DoolanDL and WardLC (1987). Amino-Acid Supply and Protein-Metabolism in Ehrlich Ascites Tumor-Cells .2. Incorporation of C-14 Tyrosine. Cytobios51 (204)49-61.
DoolanD. L. and WardL. C. (1987). Amino acid supply and protein metabolism in Ehrlich ascites tumour cells. 2. Incorporation of 14C-tyrosine. Cytobios51 (204)49-61.
Conference Papers
DoolanDeniseSarathkumaraYomaniFarrisDariseAssassiShervinJamesJudithLindseyJohn and ProiettiCarla (2025). Immune signature predictive of Multiple Sclerosis onset revealed by EBV proteome-wide profiling. ECTRIMS 2025BarcelonaSpain24-26 September 2025. LondonUnited Kingdom: Sage Publications.
SarathkumaraYomaniProiettiCarlaAssassiShervinFarrisDariseJamesJudithLindseyJohn and DoolanDenise (2025). EBV antibody signature associated with Multiple Sclerosis onset revealed by proteome-wide profiling. 41st Congress of the European Committee for Treatment and Research in Multiple SclerosisBarcelonaSpain24-26 September 2025. LondonUnited Kingdom: Sage Publications.
ProiettiCarlaKrauseLutzRoddickJoanneTrieuAngela and DoolanDenise L. (2012). Dissecting T cell or antibody immunodominance in a complex host-pathogen system. Challenges in Malaria ResearchBaselSwitzerland10-12 October 2012. LondonUnited Kingdom: BioMed Central. doi: 10.1186/1475-2875-11-s1-o23
CardosoF. C.GrovesP.RoddickJ. and DoolanD. L. (2010). Proteome-wide screening of complex pathogens to identify antigens targeted by T-cell mediated immune responses. XII International Conference for ParasitologyMelbourmeAustralia15-20 August 2010.
DriguezPatrickEllisMagdaMcWilliarnHamishTrieuAngelaGazeSorayaJonesMalcolm K.GobertGeoffLoukasAlexDoolanDenise L.FelgnerPhilip L. and McManusDonald P. (2010). Development and immunoscreening of an immunomics protein microarray to investigate schistosomiasis. 59th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH)AtlantaGAUnited States3-7 November2010. DeerfieldILUnited States : American Society of Tropical Medicine and Hygiene .
CardosoF. C.TrieuA.GrovesP. and DoolanD. L. (2010). Proteome-wide screening of antigens targeted by cell mediated immune responses. 14th International Congress of ImmunologyKobeJapan22-27 August 2010.
EngersHowardKienyMarie PauleMalhotraPawanPinkJ. RichardDaviesGwynKensilCharlotte ReadJeanninPascaleAubryJean-PierreGoetschLilianeDelnesteYvesBonnefoyJean-YvesRevetsHildeDe BaetselierPatrickStewardMichaelFritchleySarah J.BrightJeremy R.OldroydRodney G.AffleckLouise J.RossTed M.HolderAnthony A.SmithRichard A.G.KenneyRichardGlennGregoryCzerkinskyCecilDel GiudiceGiuseppeZurbriggenRinaldoGlückReinhardDraneDebbiePearseMartin ... SedegahM. (2003). Third meeting on Novel Adjuvants Currently in or Close to Clinical Testing World Health Organization - Organisation Mondiale de la SantéFondation MérieuxAnnecyFrance7-9 January 2002. Elsevier BV. doi: 10.1016/S0264-410X(03)00164-6
GramzinskiRobert A.MarisDorina C.DoolanDeniseCharoenvitYupinObaldiaNicanorRossanRichardSedegahMarthaWangRuobingHobartPeterMargalithMichal and HoffmanStephen (1997). Malaria DNA vaccines in Aotus monkeys. doi: 10.1016/S0264-410X(96)00270-8
HoffmanStephen L.DoolanDenise L.SedegahMarthaAguiarJoao C.WangRuobingMalikAnitaGramzinskiRobert A.WeissWalter R.HobartPeterNormanJon A.MargalithMichal and HedstromRichard C. (1997). Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use. doi: 10.1016/S0264-410X(96)00273-3
MurphyG. M.St. GeorgeT. D.GuerriniV.CollinsR. G.BroadmeadowA. C.UrenM. F. and DoolanD. L. (1988). Trace element and macro electrolyte behaviour during inflammatory diseases in cattle and sheep. Sixth International Symposium on Trace Elements in Man and AnimalsPacific GroveCAUnited States31 May-5 June 1987. New YorkNYUnited States: Plenum Press.