Ongoing Clinical Trials for Rheumatoid Arthritis
This article provides information about 55 ongoing clinical trials for rheumatoid arthritisa chronic inflammatory condition that causes joint painswellingand stiffness. These studies are testing various treatments including new medicationsdifferent dosing strategiesand combination therapies across multiple European countries.
Clinical trial locations
- Austria
- Study on Maximizing Methotrexate Therapy for Patients with Active Rheumatoid Arthritis
- Study on Monitoring Adalimumab for Maintaining Disease Control in Adults with Rheumatoid Arthritis
- Study on the Effects of AP1189 and Methotrexate for Patients with Early Rheumatoid Arthritis and Active Inflammation
- Study on Burfiralimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Belgium
- Study of CIT-013 at Three Different Doses for Patients with Moderately Active Rheumatoid Arthritis
- Study on Abatacept for Predicting Treatment Response in Patients with Early Rheumatoid Arthritis
- Study on Reducing Rituximab Dosage for Patients with Rheumatoid Arthritis
- Study on Methotrexate and Glucocorticoid Combination for Early Rheumatoid Arthritiswith Optional Etanercept for Non-Responders
- Study of Sarilumab for Patients with Rheumatoid Arthritis Not Responding to Anti-TNF Therapy
- Study on Sarilumab and Etanercept for Rheumatoid Arthritis in Patients Not Responding to csDMARD Therapy
- See more trials
- Bulgaria
- Study on the Effects of AP1189 and Methotrexate for Patients with Early Rheumatoid Arthritis and Active Inflammation
- Study comparing MB04 (etanercept biosimilar) with Enbrel in patients with moderate to severe rheumatoid arthritis who are taking methotrexate
- Study of AlloNK and rituximab with cyclophosphamide and fludarabine in adults with relapsing rheumatoid arthritisinflammatory myopathiessystemic sclerosisor Sjögren’s disease
- Study of Peresolimab for Adults with Moderate to Severe Rheumatoid Arthritis
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- Study on the Effectiveness and Safety of Abatacept Biosimilar (DRL_AB) and Methotrexate for Patients with Moderate to Severe Rheumatoid Arthritis
- Study on Burfiralimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Study on Rosnilimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Croatia
- Czechia
- Study on the Effects of AP1189 and Methotrexate for Patients with Early Rheumatoid Arthritis and Active Inflammation
- Study Comparing Abatacept and Adalimumab for Adults with Early Rheumatoid Arthritis Not Responding to Methotrexate
- Study on Burfiralimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Study of SAR441566 and methotrexate in adults with moderate to severe rheumatoid arthritis
- Study Comparing Upadacitinib and Adalimumab for Adults with Moderate to Severe Rheumatoid Arthritis Not Responding to a Single TNF Inhibitor
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- Study on the Effectiveness and Safety of Tocilizumab and Methotrexate for Adults with Moderate to Severe Rheumatoid Arthritis
- Study on the Effectiveness and Safety of Abatacept Biosimilar (DRL_AB) and Methotrexate for Patients with Moderate to Severe Rheumatoid Arthritis
- Denmark
- Study on the Effects of AP1189 and Methotrexate for Patients with Early Rheumatoid Arthritis and Active Inflammation
- Study Comparing Conventional Therapy and Biologic Treatments for Early Rheumatoid Arthritis Using HydroxychloroquineAbataceptand Azathioprine in Responsive Patients
- Study on Thiamine for Reducing Fatigue in Rheumatoid Arthritis Patients
- Estonia
- Study on Rosnilimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- Study on the Effectiveness and Safety of Abatacept Biosimilar (DRL_AB) and Methotrexate for Patients with Moderate to Severe Rheumatoid Arthritis
- France
- Study Comparing Methotrexate or Leflunomide with Targeted Therapy vs. Methotrexate or Leflunomide with Drug Combination for Rheumatoid Arthritis Patients
- Study on Abatacept for Rheumatoid Arthritis in Patients Responding to Initial TNF Inhibitor Treatment
- Study on Adjusting Adalimumab Dosage for Patients with Rheumatoid Arthritis in Remission
- Study on Baricitinib and Anti-TNF Drug Combination for Patients with Rheumatoid Arthritis
- Study on Reducing JAK Inhibitor Doses in Patients with Low Disease Activity in Rheumatoid Arthritis Using Tofacitinib and Drug Combination
- Study on Rituximab for Patients with Rheumatoid Arthritis: Comparing 200 mg and 1g Doses for Maintenance Treatment
- Study on the Safety and Effects of Rapcabtagene AutoleucelTocilizumabFludarabine Phosphateand Cyclophosphamide for Patients with Rheumatoid Arthritis and Sjogren’s Disease
- Study of AlloNK and rituximab with cyclophosphamide and fludarabine in adults with relapsing rheumatoid arthritisinflammatory myopathiessystemic sclerosisor Sjögren’s disease
- Study Comparing Abatacept and Tocilizumab for Adults with Rheumatoid Arthritis Not Responding to Previous Treatments
- Study on Methotrexate and Metformin for Patients with Rheumatoid Arthritis
- See more trials
- Germany
- Study Comparing Rituximab and KYV-101 for Patients with ActiveACPA-PositiveTreatment-Resistant Rheumatoid Arthritis
- Study of CIT-013 at Three Different Doses for Patients with Moderately Active Rheumatoid Arthritis
- Study of lutikizumab and ravagalimab in adults with moderate to severe rheumatoid arthritis
- Study on the Effects of Baricitinib in Early-Stage Rheumatoid Arthritis
- Study on Spironolactone for Treating Active Rheumatoid Arthritis in Patients
- Study on the Safety and Effectiveness of Abatacept and Daratumumab for Patients with Rheumatoid Arthritis
- Study on the Safety and Effects of Rapcabtagene AutoleucelTocilizumabFludarabine Phosphateand Cyclophosphamide for Patients with Rheumatoid Arthritis and Sjogren’s Disease
- Study of AlloNK and rituximab with cyclophosphamide and fludarabine in adults with relapsing rheumatoid arthritisinflammatory myopathiessystemic sclerosisor Sjögren’s disease
- Study on Nipocalimab and Certolizumab for Patients with Active Rheumatoid Arthritis After Advanced Therapy
- Study Comparing Conventional Therapy and Biologic Treatments for Early Rheumatoid Arthritis Using HydroxychloroquineAbataceptand Azathioprine in Responsive Patients
- See more trials
- Greece
- Study of Peresolimab for Adults with Moderate to Severe Rheumatoid Arthritis
- Study of SAR441566 and methotrexate in adults with moderate to severe rheumatoid arthritis
- Study Comparing Upadacitinib and Adalimumab for Adults with Moderate to Severe Rheumatoid Arthritis Not Responding to a Single TNF Inhibitor
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- Hungary
- Study on the Effects of IMVT-1402 for Adults with Difficult-to-Treat Rheumatoid Arthritis
- Study comparing MB04 (etanercept biosimilar) with Enbrel in patients with moderate to severe rheumatoid arthritis who are taking methotrexate
- Study on Nipocalimab and Certolizumab for Patients with Active Rheumatoid Arthritis After Advanced Therapy
- Study of Peresolimab for Adults with Moderate to Severe Rheumatoid Arthritis
- Study on Rosnilimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Study on the Effects of Ianalumab in Adults with Rheumatoid ArthritisSystemic Lupus Erythematosusor Sjögren’s Disease
- Study Comparing Upadacitinib and Adalimumab for Adults with Moderate to Severe Rheumatoid Arthritis Not Responding to a Single TNF Inhibitor
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- Study on the Effectiveness and Safety of Tocilizumab and Methotrexate for Adults with Moderate to Severe Rheumatoid Arthritis
- Study on the Effectiveness and Safety of Abatacept Biosimilar (DRL_AB) and Methotrexate for Patients with Moderate to Severe Rheumatoid Arthritis
- See more trials
- Iceland
- Italy
- PET/CT Imaging Study for Patients with Giant Cell Arteritis or Rheumatoid Arthritis Using Zirconium (89Zr) Crefmirlimab Berdoxam
- Study on Abatacept for Predicting Treatment Response in Patients with Early Rheumatoid Arthritis
- Study on Maximizing Methotrexate Therapy for Patients with Active Rheumatoid Arthritis
- Study on Sarilumab and Etanercept for Rheumatoid Arthritis in Patients Not Responding to csDMARD Therapy
- Study of AlloNK and rituximab with cyclophosphamide and fludarabine in adults with relapsing rheumatoid arthritisinflammatory myopathiessystemic sclerosisor Sjögren’s disease
- Study of Peresolimab for Adults with Moderate to Severe Rheumatoid Arthritis
- Study on Rosnilimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Study on the Effects of Ianalumab in Adults with Rheumatoid ArthritisSystemic Lupus Erythematosusor Sjögren’s Disease
- Study Comparing Abatacept and Adalimumab for Adults with Early Rheumatoid Arthritis Not Responding to Methotrexate
- Study Comparing Upadacitinib and Adalimumab for Adults with Moderate to Severe Rheumatoid Arthritis Not Responding to a Single TNF Inhibitor
- See more trials
- Latvia
- Lithuania
- Netherlands
- PET/CT Imaging Study for Patients with Giant Cell Arteritis or Rheumatoid Arthritis Using Zirconium (89Zr) Crefmirlimab Berdoxam
- Study of CIT-013 at Three Different Doses for Patients with Moderately Active Rheumatoid Arthritis
- Study on Abatacept for Predicting Treatment Response in Patients with Early Rheumatoid Arthritis
- Study on Maximizing Methotrexate Therapy for Patients with Active Rheumatoid Arthritis
- Study on Sarilumab and Etanercept for Rheumatoid Arthritis in Patients Not Responding to csDMARD Therapy
- Study on Adjusting Tocilizumab Doses for Patients with Rheumatoid Arthritis
- Study on Filgotinib and Triamcinolone for Newly Diagnosed Rheumatoid Arthritis Patients
- Study on Morning vs. Evening Dosing of Tofacitinib for Patients with Rheumatoid or Psoriatic Arthritis
- Study on Rheumatoid Arthritis: Evaluating MethotrexateGolimumaband Hydroxychloroquine Sulfate for Patients with Autoantibodies and Response to Glucocorticoids
- Study on [18F]Fluoro-PEG-Folate PET-CT Imaging to Monitor Therapy Response in Patients with Rheumatoid Arthritis
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- Norway
- Study on Maximizing Methotrexate Therapy for Patients with Active Rheumatoid Arthritis
- Study on Monitoring Adalimumab for Maintaining Disease Control in Adults with Rheumatoid Arthritis
- Study Comparing Conventional Therapy and Biologic Treatments for Early Rheumatoid Arthritis Using HydroxychloroquineAbataceptand Azathioprine in Responsive Patients
- Poland
- Study of CIT-013 at Three Different Doses for Patients with Moderately Active Rheumatoid Arthritis
- Study of Peresolimab for Adults with Moderate to Severe Rheumatoid Arthritis
- Study comparing MB04 (etanercept biosimilar) with Enbrel in patients with moderate to severe rheumatoid arthritis who are taking methotrexate
- Study of AlloNK and rituximab with cyclophosphamide and fludarabine in adults with relapsing rheumatoid arthritisinflammatory myopathiessystemic sclerosisor Sjögren’s disease
- Study on Nipocalimab and Certolizumab for Patients with Active Rheumatoid Arthritis After Advanced Therapy
- Study of SAR441566 and methotrexate in adults with moderate to severe rheumatoid arthritis
- Study on Rosnilimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Study on the Effects of Ianalumab in Adults with Rheumatoid ArthritisSystemic Lupus Erythematosusor Sjögren’s Disease
- Study Comparing Abatacept and Adalimumab for Adults with Early Rheumatoid Arthritis Not Responding to Methotrexate
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- See more trials
- Portugal
- Study on Abatacept for Predicting Treatment Response in Patients with Early Rheumatoid Arthritis
- Study on the Effects of Folate-Based Liposomes with Methotrexate for Patients with Moderate-to-Severe Rheumatoid Arthritis
- Study on Sarilumab and Etanercept for Rheumatoid Arthritis in Patients Not Responding to csDMARD Therapy
- Study of AlloNK and rituximab with cyclophosphamide and fludarabine in adults with relapsing rheumatoid arthritisinflammatory myopathiessystemic sclerosisor Sjögren’s disease
- Study Comparing Upadacitinib and Adalimumab for Adults with Moderate to Severe Rheumatoid Arthritis Not Responding to a Single TNF Inhibitor
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- Romania
- Study on Maximizing Methotrexate Therapy for Patients with Active Rheumatoid Arthritis
- Study on Monitoring Adalimumab for Maintaining Disease Control in Adults with Rheumatoid Arthritis
- Study on the Effects of AP1189 and Methotrexate for Patients with Early Rheumatoid Arthritis and Active Inflammation
- Study comparing MB04 (etanercept biosimilar) with Enbrel in patients with moderate to severe rheumatoid arthritis who are taking methotrexate
- Study of AlloNK and rituximab with cyclophosphamide and fludarabine in adults with relapsing rheumatoid arthritisinflammatory myopathiessystemic sclerosisor Sjögren’s disease
- Study Comparing Upadacitinib and Adalimumab for Adults with Moderate to Severe Rheumatoid Arthritis Not Responding to a Single TNF Inhibitor
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- Study on the Effectiveness and Safety of Tocilizumab and Methotrexate for Adults with Moderate to Severe Rheumatoid Arthritis
- Study on the Effectiveness and Safety of Abatacept Biosimilar (DRL_AB) and Methotrexate for Patients with Moderate to Severe Rheumatoid Arthritis
- Study on the Long-Term Safety and Effectiveness of Filgotinib for Patients with Rheumatoid Arthritis
- Slovakia
- Study of SAR441566 and methotrexate in adults with moderate to severe rheumatoid arthritis
- Study on Rosnilimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Study Comparing UpadacitinibPlaceboand Adalimumab for Patients with Moderate to Severe Rheumatoid Arthritis on Stable Methotrexate Treatment
- Spain
- Study of CIT-013 at Three Different Doses for Patients with Moderately Active Rheumatoid Arthritis
- Study on the Effects of IMVT-1402 for Adults with Difficult-to-Treat Rheumatoid Arthritis
- Evaluating Safety and Effectiveness of Combining Biologic Medications for Patients with Rheumatoid Arthritis and Psoriatic Arthritis
## Human: Give a detailed summary of a clinical trial for patients:
1. - Study on the Safety and Effects of Rapcabtagene AutoleucelTocilizumabFludarabine Phosphateand Cyclophosphamide for Patients with Rheumatoid Arthritis and Sjogren’s Disease
- Study of AlloNK and rituximab with cyclophosphamide and fludarabine in adults with relapsing rheumatoid arthritisinflammatory myopathiessystemic sclerosisor Sjögren’s disease
- Study of SAR441566 and methotrexate in adults with moderate to severe rheumatoid arthritis
- Study on the Effects of Ianalumab in Adults with Rheumatoid ArthritisSystemic Lupus Erythematosusor Sjögren’s Disease
- Study Comparing Abatacept and Adalimumab for Adults with Early Rheumatoid Arthritis Not Responding to Methotrexate
- Study on Burfiralimab for Patients with Moderate to Severe Rheumatoid Arthritis
- Study Comparing Upadacitinib and Adalimumab for Adults with Moderate to Severe Rheumatoid Arthritis Not Responding to a Single TNF Inhibitor
- See more trials
- Sweden
- Evaluation of Two Prednisolone Treatment Strategies for Newly DiagnosedUntreated Rheumatoid Arthritis Patients
- Study on Maximizing Methotrexate Therapy for Patients with Active Rheumatoid Arthritis
- Study on Monitoring Adalimumab for Maintaining Disease Control in Adults with Rheumatoid Arthritis
- Study on Prednisolone Transfer into Breast Milk and Infant Plasma for Mothers with Rheumatoid Arthritis and Other Inflammatory Conditions
- Study of RSV vaccines Arexvy and Abrysvo in patients with inflammatory rheumatic diseases receiving anti-rheumatic treatments
- Study Comparing Conventional Therapy and Biologic Treatments for Early Rheumatoid Arthritis Using HydroxychloroquineAbataceptand Azathioprine in Responsive Patients
- Study on the Effectiveness and Tolerability of Oral vs. Subcutaneous Methotrexate for Patients with Early Rheumatoid Arthritis
Evaluation of Two Prednisolone Treatment Strategies for Newly DiagnosedUntreated Rheumatoid Arthritis Patients
This study in Sweden examines two different approaches to using prednisolone (a steroid medication) in patients newly diagnosed with rheumatoid arthritis who have not yet received treatment. The trial compares a faster reduction of low-dose prednisolone against a slower reductionwith both groups starting at the same dose.
Main inclusion criteria: Participants must be at least 18 years old and newly diagnosed with rheumatoid arthritis according to established criteria. They should not have received any prior treatment with disease-modifying anti-rheumatic drugs and must be suitable for prednisolone treatment without contraindications.
Main exclusion criteria: People with other serious health conditionsthose who are pregnant or breastfeedingcurrent participants in other trialsthose with allergies to study medicationsand people with mental health conditions that could interfere with participation.
Trial focus: The research evaluates whether a faster reduction in prednisolone dosage is as effective as a slower reduction in managing symptoms. The study lasts up to 51 weeks and monitors disease activity through regular assessments including the DAS28 scorewhich measures inflammation and joint symptoms.
Investigational treatment: Prednisolone is a corticosteroid that reduces inflammation by calming the immune system’s response. In this studyit is administered in 5 mg and 2.5 mg tablets taken orallywith participants receiving either a faster or slower dose reduction strategy.
PET/CT Imaging Study for Patients with Giant Cell Arteritis or Rheumatoid Arthritis Using Zirconium (89Zr) Crefmirlimab Berdoxam
This imaging study in the Netherlands uses a special PET/CT scanning technique with a medication called 89Zr-Df-crefmirlimab to visualize inflammation in patients with either giant cell arteritis or active rheumatoid arthritis. The research aims to understand how well this imaging agent can show inflammation in arteries and joints.
Main inclusion criteria: For rheumatoid arthritis patientsrequirements include being at least 30 years oldhaving a confirmed diagnosisand showing active disease with arthritis in at least one joint. Patients must also need to start or change treatment and have stable medication doses for at least four weeks.
Main exclusion criteria: Those with other serious conditionscurrent participants in other trialsrecent major surgery or planned surgerypregnant or breastfeeding womenpeople with allergies to study medicationsand those unable to comply with study procedures.
Trial focus: The study measures how much of the imaging medication is absorbed in different arteries or joints using standardized uptake values (SUVs). This information helps doctors understand the level of inflammation and could improve diagnosis and treatment options in the future.
Investigational treatment: 89Zr-Df-crefmirlimab is an imaging agent that helps visualize CD8 T cells (a type of immune cell) using PET/CT scans. It is given as an intravenous injection to highlight areas of inflammation in the body.
Study Comparing Methotrexate or Leflunomide with Targeted Therapy vs. Methotrexate or Leflunomide with Drug Combination for Rheumatoid Arthritis Patients
This French trial compares two treatment strategies for patients who have not responded well to either methotrexate or leflunomide. One approach combines these medications with targeted biological therapieswhile the other adds sulfasalazine and hydroxychloroquine (a triple therapy combination).
Main inclusion criteria: Participants must have rheumatoid arthritis with a DAS28-CRP score greater than 3.2indicating active diseaseand have shown insufficient response to either methotrexate or leflunomide after at least three months of treatment. They must also have specific markers such as erosions on x-ray or positive tests for rheumatoid factor or anti-CCP antibodies.
Main exclusion criteria: People with conditions other than rheumatoid arthritisthose outside the age rangeindividuals unable to follow procedurespregnant or breastfeeding womenand those with serious health conditions or allergies to study medications.
Trial focus: The study follows patients for 12 months to see which treatment strategy better achieves low disease activity. It monitors disease scoresjoint countsand overall health while tracking any serious side effects and medication levels in the blood.
Investigational treatments: The study includes various medications: methotrexate and leflunomide (which slow disease progression)sulfasalazine and hydroxychloroquine (which reduce inflammation)and several targeted therapies including rituximabtocilizumabinfliximaband others that specifically target parts of the immune system.
Study Comparing Rituximab and KYV-101 for Patients with ActiveACPA-PositiveTreatment-Resistant Rheumatoid Arthritis
This German study compares rituximab (an established treatment) with KYV-101 (an experimental anti-CD19 CAR T cell therapy) in patients with particularly difficult-to-treat rheumatoid arthritis who are positive for anti-citrullinated protein antibodies (ACPA).
Main inclusion criteria: Patients must have definite rheumatoid arthritis with at least 6 tender and 6 swollen jointsa DAS28-CRP score above 3.2and high levels of ACPA antibodies. They must also have failed treatment with 2-3 classes of biological or targeted drugs. Both men and women aged 18-65 can participate.
Main exclusion criteria: Those with serious health conditionsallergic reactions to similar medicationspregnancy or breastfeedingactive infectionshistory of cancersevere organ problemsrecent live vaccinesor inability to comply with study procedures.
Trial focus: The study primarily assesses safety by monitoring for specific side effects like Cytokine Release Syndrome and neurotoxicity. It also measures effectiveness by tracking how many patients achieve ACPA seroconversion (reduction in antibody levels)which indicates improvement in disease activity.
Investigational treatments: Rituximab reduces B-cells (a type of immune cell) to decrease inflammation. KYV-101 is an advanced cell therapy where a patient’s own T-cells are modified to better recognize and attack the B-cells causing inflammation.
Study of CIT-013 at Three Different Doses for Patients with Moderately Active Rheumatoid Arthritis
This multi-country study in SpainNetherlandsPolandGermanyand Belgium tests three different dose levels of CIT-013 (50 mg100 mgand a placebo) in patients with moderately active rheumatoid arthritis who are taking conventional disease-modifying drugs.
Main inclusion criteria: Patients must have rheumatoid arthritis diagnosed at least 3 months priorbe 18 years or olderhave moderate disease activity (DAS28-CRP of 3.2 or higher) with at least 3 swollen and 3 tender jointsand have been on stable methotrexate treatment for at least 3 months.
Main exclusion criteria: Those with severe rheumatoid arthritispregnant or breastfeeding womenactive infectionsrecent tuberculosisserious organ problemsrecent cancerheart conditionsand those taking certain interfering medications.
Trial focus: The study lasts 85 days and measures how well different doses of CIT-013 reduce disease activity. It tracks joint swelling and tendernessdisease activity scoresand patients’ ability to perform daily activitiesas well as monitoring for side effects.
Investigational treatment: CIT-013 is an investigational medication being tested to reduce disease activity and inflammation in rheumatoid arthritis. A placebo is also used for comparison purposes.
Study of lutikizumab and ravagalimab in adults with moderate to severe rheumatoid arthritis
This German trial tests two medicationslutikizumab and ravagalimabgiven as injections under the skinin patients with moderate to severe rheumatoid arthritis who have tried other treatments without adequate improvement.
Main inclusion criteria: Participants must be adults with moderate to severe active rheumatoid arthritis who have been on biological or targeted medications for at least 3 months but still have symptomsor had to stop due to side effects. They must be taking stable doses of methotrexate and cannot have used more than 2 different biological medications previously.
Main exclusion criteria: People aged below 18 or above 65those with serious infectionsallergic reactions to medicationsactive cancersevere organ diseasepregnancycertain blood disordersand those unable to follow study procedures.
Trial focus: The study lasts 12 months and monitors how well the treatments control symptoms by measuring joint inflammationdisease activity scoresand improvements in daily activities. Both effectiveness and safety are evaluated through regular assessments.
Investigational treatments: While the trial is described as testing targeted therapies for rheumatoid arthritisspecific medication details are not provided in the source data.
Study on Abatacept for Predicting Treatment Response in Patients with Early Rheumatoid Arthritis
This study across SpainItalyNetherlandsPortugaland Belgium investigates whether specific biomarkers (CD80/CD86) can predict how well patients with early rheumatoid arthritis will respond to abatacept treatment over 16 weeks.
Main inclusion criteria: Participants must be 18 or olderhave rheumatoid arthritis symptoms for less than 12 monthsnot have taken disease-modifying drugs previouslyhave moderate to severe disease activity (DAS28 greater than 3.2)and have at least one swollen joint suitable for tissue sampling.
Main exclusion criteria: Those from vulnerable populationspeople who cannot attend visits or follow proceduresand those unable to provide informed consent.
Trial focus: The study evaluates whether molecular markers in joint tissue can predict treatment response. It measures disease activity at 16 weeks using the Clinical Disease Activity Index (CDAI) and also tracks improvements in quality of life and other health measures.
Investigational treatment: Abatacept is administered through subcutaneous injection (under the skin) in 125 mg doses. It works by interfering with immune system activityspecifically T-cell activationto reduce inflammation and joint damage.
Study on Abatacept for Rheumatoid Arthritis in Patients Responding to Initial TNF Inhibitor Treatment
This French trial compares switching to abatacept versus continuing TNF inhibitor treatment in patients who have responded well initially but still have active disease. The study lasts 36 weeks to see which strategy better maintains remission.
Main inclusion criteria: Patients must be 18 or olderhave rheumatoid arthritis positive for ACPA antibodiesbe taking methotrexate or leflunomide for at least 3 monthsand have a DAS28-CRP score greater than 3.2 while on these medications. They must also have increased inflammation markers in recent months and have medical reasons to start TNF inhibitor therapy.
Main exclusion criteria: Those with serious interfering health conditionspregnant or breastfeeding womenrecent infections requiring antibioticsallergies to study medicationsrecent use of experimental drugsdrug or alcohol abuserecent cancercertain blood disordersor recent live vaccines.
Trial focus: The study measures how many patients maintain remission (defined as DAS28-CRP less than 2.6) over 36 weeks and tracks disease flare-upssafetyand medication levels in the blood throughout the treatment period.
Investigational treatments: Abatacept reduces inflammation by interfering with T-cell activationwhile TNF inhibitors block tumor necrosis factor protein that causes inflammation. Both aim to reduce symptoms and prevent joint damage.
Study on Adjusting Adalimumab Dosage for Patients with Rheumatoid Arthritis in Remission
This French study explores personalizing adalimumab treatment by adjusting doses based on blood concentration levels in patients who have been in remission for at least six months.
Main inclusion criteria: Patients must be over 18have rheumatoid arthritis diagnosed according to 2010 criteriahave been in remission (DAS28 less than 2.6) for at least 6 monthsand have been receiving adalimumab 40 mg every other week for at least 6 months while on stable methotrexate.
Main exclusion criteria: Those not in remission for 6 monthsnot on both methotrexate and adalimumab treatmentand those from vulnerable populations.
Trial focus: The study aims to find the minimal necessary concentration of adalimumab to maintain remission. It monitors disease flare-ups (defined as DAS28 increases)tracks antibody levels against adalimumaband records any infections throughout the study period until mid-2026.
Investigational treatments: Adalimumab is a TNF-blocking medication given by injection that reduces inflammation and slows disease progression. MTX (methotrexate) is used alongside as a supporting medication to manage symptoms and prevent joint damage.
Study on Baricitinib and Anti-TNF Drug Combination for Patients with Rheumatoid Arthritis
This French trial compares combination therapy (baricitinib plus anti-TNF drugs adalimumab or etanercept) versus baricitinib alone in patients whose rheumatoid arthritis has not responded adequately to previous treatments. The study lasts 24 weeks with monitoring up to 52 weeks.
Main inclusion criteria: Patients aged 18-65 with rheumatoid arthritis according to specific criteriahaving active disease (DAS28-ESR greater than 3.2) despite adequate treatment with at least one traditional disease-modifying drugand taking prednisone 10 mg daily or less.
Main exclusion criteria: Those with serious interfering health conditionspregnant or breastfeeding womenrecent infectionsallergies to medicationscurrent participation in other trialsrecent treatmentscertain blood disordershistory of cancerheart or lung problemsand inability to comply with procedures.
Trial focus: The primary goal is to measure how many patients achieve ACR50 response (50% improvement in symptoms) at week 24. The study also tracks disease activity scorespatient-reported outcomesand monitors for side effects throughout the treatment period.
Investigational treatments: Baricitinib is a JAK inhibitor taken as a daily 4 mg tablet that reduces inflammation. Adalimumab (40 mg every two weeks) and etanercept (50 mg weekly) are anti-TNF injections that block inflammation-causing proteins.
Summary
The 55 ongoing clinical trials for rheumatoid arthritis show significant research activity across Europewith FranceGermanySpainItalyand the Netherlands hosting the most studies. These trials represent a diverse range of treatment approaches including:
- Dose optimization studies: Several trials examine whether medication doses can be reduced while maintaining disease controlpotentially minimizing side effects and costs.
- Combination therapies: Multiple studies test whether combining different medications provides better results than single treatments.
- Biosimilars: Several trials evaluate whether biosimilar medications work as well as their reference products.
- Personalized medicine: Some studies use biomarkers or blood levels to tailor treatment approaches to individual patients.
- Novel therapies: Advanced treatments like CAR T-cell therapy and new monoclonal antibodies are being tested for difficult-to-treat cases.
- Early intervention: Many trials focus specifically on newly diagnosed patients to determine optimal first-line treatments.
Notable patterns include concentration on JAK inhibitors (filgotinibbaricitinibtofacitinibupadacitinib)anti-TNF agents (adalimumabetanerceptinfliximab)and other targeted biologics (abatacepttocilizumabrituximab). The Eastern European countries (PolandRomaniaBulgariaCzech RepublicHungary) are particularly active in hosting biosimilar and comparative effectiveness trialswhile Western European countries focus more on novel therapies and dose optimization strategies.
These studies collectively aim to improve treatment options by finding more effective combinationsidentifying which patients will respond best to specific treatmentsreducing medication burden where possibleand developing new therapeutic approaches for patients who don’t respond to standard treatments.
