The TrialLaunch Program

The CoMeT Clinical Trial 

The Corticosteroid Meniscectomy Randomized Trial is a phase 4 study that evaluates extended-release triamcinolone (Zilretta) to reduce inflammation and improve recovery after arthroscopic partial meniscectomy (APM) for osteoarthritis. While 70% of APM patients see symptom reliefoutcomes varylikely due to unmeasured inflammation. Led by Morgan H. JonesMDMPHfrom Brigham and Women’s Hospital and funded by the Arthritis Foundation and Pacira BioSciencesthe study examines Zilretta’s impact on knee painfunction and structural damage. CoMeT is a predecessor of the PIKASO Project. Read more about CoMeT.

The MOCHA Clinical Trial 

The Montelukast as a Chondroprotective treatment following ACL reconstruction trial is an internationalphase 1 clinical study testing whether a six-month course of the drug montelukast (Singulair) can slow or stop cartilage degradation in post-traumatic osteoarthritis (PTOA). As a predecessor to PIKASOMOCHA — led by Cale JacobsPhDfrom Mass General Brigham and Austin StoneMDfrom University of Kentucky — establishes key conceptslike patient-reported outcomes and biomarker testing. It is part of a program fostering early-stage OA Clinical Trial Network (OACTN) trials. Read more about MOCHA.

The Weight-Bearing Computerized Tomography Study 

Led by Donald D. AndersonPhDand Brian R. WolfMDfrom the University of Iowathis study utilizes weight-bearing computerized tomography — a tool to measure bone structures while a subject is standing or walking — to evaluate risk for post-traumatic osteoarthritis after ACL reconstruction.

The TarHEAL Study 

The Targeting Joint Health Early After ACL Injury studyled by Brian PietrosimonePhDexamines how knee joint stress and movement patterns change from ACL injury to post-reconstructionhelping to identify risks for PTOA. A predecessor to PIKASOthis study informs future treatments and advances research in biomechanical and joint imaging techniques.

The Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction Clinical Trial 

Led by Miguel OteroPhDfrom Hospital for Special Surgerythis phase 2 pilot trial tests whether concentrated bone marrow aspirate can improve pain and inflammation in patients undergoing revision ACL surgery for PTOA. It explores how concentrated bone marrow aspirate affects symptoms and inflammation levelsand which components may drive its potential benefits. Read more about the Bone Marrow Aspirate Concentrate (BMAC) study.

The External Focus of Attention Post-Traumatic Osteoarthritis Clinical Trial 

ACL injuries are common and often treated with reconstructionbut this does not prevent future injury or arthritis. Led by Abbey ThomasPhDfrom University of North Carolina at Charlottethis interventional study examines whether certain new ways of providing feedback about the way people move can help to modify movement patterns more effectively than standard treatments that are known to raise the risk for PTOA.

The OASIS Study 

Led by Dan WhiteSc.D.from the University of Delawarethe Observational Arthritis Foundation Internet Study explores how reducing sedentary behavior and increasing physical activity affects painfunction and quality of life in 500 adults with arthritis. The results of this internet-recruited study will help define activity targets to guide future clinical trials. Read more about OASIS.