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Franklin by QIAGEN An openAI-powered variant analysis software for clinical decision support Franklin by QIAGEN is a cloud-basedAI-powered platform that integrates the world’s first open genomic community to power precision medicine at scale.
Learn how to access HGMD data in Franklin's variant analysis workflow.
Learn more
New! HGMD Professional now inside Franklin No more platform switching—just instant access to classificationsmutation summariesphenotype associations and supporting literature. Seamlessly integrated into Franklin by QIAGENHGMD Professional brings gold-standardexpert-curated evidence directly into your workflow.
AI-powered workflows with expert-curated evidence Intuitiveuser-friendly interface to simplify variant classification Interpret germline variants with unprecedented speed and accuracy Learn more The world’s first open professional genomic community Franklin’s open genomic community is a globalcollaborative network that accelerates genomic interpretation.
Collective intelligence Over 50,000 genomic professionals contribute variant classifications and case insightsforming a dynamicexpert-driven knowledge base.
Real-world evidence sharing Anonymizedclinically validated data helps users interpret rare or novel variants with more confidence and speed.
Collaborative validation Franklin fuels discovery through shared breakthroughscollaborative case resolution and mutual learning to boost accuracycut turnaround time and improve outcomes across the genomic ecosystem.
Why Franklin by QIAGEN? Streamline the path from raw data to final report with Franklin by QIAGEN. Our end-to-end variant analysis and interpretation platform leverages community and proprietary data in a cloud-based AI framework. Franklin's agnostic designcompatible with any platformkit or enrichment technologysupports the full genetic sequencing process and lets users evolve their workflows without ever being "locked in."
Helps you build an integratedcentralizedin-platform knowledge base with your own curated genetic data and clinical evidence Enables collaborative knowledge management within teamsacross departments and networks of institutions Supports both germline and somatic applicationsincluding WES and WGS Includes AI-powered variant interpretationautomated ACMG classification and customizable workflows Well-suited for hereditary genomics and rare disease analysis Enhances secondary analysis workflows with quality control and annotation tools Offers robustAI-driven tertiary analysis to interpret and classify genomic data Supports CMA and long-read sequencing Provides flexible data importrobust variant interpretation tools and customizable workflows Tailored to handle structural variantscopy number change and complex genomic regions Empowering genomic interpretation through smart data sharing Franklin by QIAGEN is built on the belief that responsibleefficient data-sharing is essential to advancing the genetics field.
Effortless data sharing: Franklin enables one-click sharing of de-identified variant insightsseamlessly integrated into the interpretation workflow without adding to daily tasks.Robust clinical support: The platform supports use cases like rare diseases and carrier screening with automated ACMG-based classification and rich variant evidence.Community-powered insights: Users benefit from expert-driven collaboration within Franklin’s open networkaccelerating interpretation through shared real-world data.Resolve variants of unknown significance Franklin empowers users to resolve uncertain variants by enabling real-time collaboration and data sharing across a global community of experts. Its additional data layer has already led to the reclassification of many VUSs and the discovery of rare causal variantsthanks to collective insights and shared experiences.
Collaborative interpretation: Start variant or case discussions and connect with peers who have seen similar findings to resolve uncertainty.Community frequency database: Franklin aggregates variant data across cases to highlight common variants in global and population-specific contexts.Expert-to-expert outreach: Directly contact others who have seen the same variant to share case evidenceaiding accurate and timely classification.Compare Franklin plans: Free vs. Premium Franklin by QIAGEN offers both Free and Premium access levelsdesigned to meet the needs of individual users and institutional teams. Whether you're exploring genomic data independently or managing complex workflows at scaleour variant analysis software delivers the tools you need to power precision medicine.
Free version Ideal for individual cliniciansgenetic counselors and researchers looking to exploreinterpret and share genomic insights.
Access to the Franklin Variant Interpretation Hub
Search and view public variant classificationsannotations and community insights
Manage and store a limited number of cases
Engage with the global Franklin community through the Community Feed
Access curated public databases (ClinVargnomAdetc.)
Participate in variant-level discussions and knowledge sharing
Share and search for free Premium version Designed for laboratorieshospitals and research teams needing advanced toolsscalability and institutional collaboration.
Scalable case management and advanced cohort analytics
Customizable workflows and institution-wide knowledge base
Configurable virtual gene panels and interpretation templates
Discovery feature for scalable cohort and family-based queries
Priority supportexpert onboardingAPI access and integration capabilities
Upgrade to premium Contact us Want expert help? Request a free consultation We recommend starting with free access to Franklin’s community-powered variant analysis software – no setupno cost. Thenwhen you're ready to go deeperrequest a complimentary consultation with one of our genomic experts.
Request consultation Franklin is a variant analysis research tool for analyzing human genetics data and is not intended to be used for diagnostic purposes.
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