Objective: To conduct a scoping review of the global trends of adolescent health inequities and their social determinants from 2000 to 2024 and establish an evidence base for developing targeted intervention strategies. Methods: Guided by the rainbow modelwe conducted a bibliometric analysis of 171 peer-reviewed articles related to adolescent health inequalities and their social determinants from the Web of Science Core Collection using CiteSpace 6.3.1 to summarize empirical evidence on how social determinants of health (SDOH) influence adolescents' health behaviors (e.g.drinking) and health outcomes (e.g.overweight). Results: Firstresults showed a progressive increase in publications addressing social determinants of adolescent health from 2000 to 2024. Journals in public health and preventive medicine accounted for the highest proportion of articleswith the United States contributing the largest national share (21.05% of global output). Secondan analysis of keywords showed that previous studies mostly focused on the effects of socioeconomic statusfamily affluence on adolescent health (e.g.physical activitymental healthand overweight). Thirdinequalities in adolescent health were prevalent globally. Health behaviors (e.g.dietoral healthand smoking) have received widespread attention and are influenced by socioeconomic statusfamily environmentand genderwhereas various indicators of adolescent health outcomes (e.g.obesitymental healthand suicide) were highly correlated with family socioeconomic status. Conclusions: To reduce adolescent health disparitiesit is important to deepen interdisciplinary researchconsider the impact of emerging societal (e.g.digital environments) and environmental factors (e.g.climate change)and develop systematic and comprehensive intervention strategies that encompass the individualfamilyschoolcommunityand national levels.