PubMed User Guide

Last update: February 52026

Follow PubMed New and Noteworthy for brief announcements highlighting recent enhancements and changes to PubMed.

FAQs

• How can I get the full text article? What if the link to the full text is not working?
• How do I search by author?
• How do I search by journal name?
• How do I find a specific citation? I have some information such as the authorjournal nameand publication year.
• I retrieved too many citations. How can I focus my search?
• I retrieved too few citations. How can I expand my search?
• How do I find consumer health information about a disease or condition?
• How do I find systematic reviews?
• Are there tools to help with clinical searches or finding medical genetics information?
• I’m not finding what I need. How does a PubMed search work?
• Can you explain what is shown on the search results?
• How do I display an abstract?
• How can I save my results?
• Can I receive email updates when new results are available for my search?
• How do I report an error or duplicate citation in PubMed?
• How can I cite an article or export citations to my citation management software program?
• How do I get a link to bookmark or share my PubMed search?
• How can I download PubMed?
• Is there a guide to NLM resources for MEDLINE/PubMed?
• Where can I find further assistance and training?

Search PubMed

• How do I search PubMed?
• I retrieved too many citations. How can I focus my search?
• I retrieved too few citations. How can I expand my search?
• Find a specific citation
• Searching by author
• Searching by journal
• Searching by date
• Filters
• Searching for a phrase
• Wildcards and truncation
• Combining search terms with Boolean operators (ANDORNOT)
• Using search field tags
• Proximity searching

How do I search PubMed?

1. Identify the key concepts for your search. 
2. Enter the terms (or key concepts) in the search box.
3. Press the Enter key or click Search.

For many searchesit is not necessary to use special tags or syntax. PubMed uses multiple tools to help you find relevant results:

• Best Match sort order uses a state-of-the-art machine learning algorithm to place the most relevant citations at the top of your results.
• An autocomplete feature displays suggestions as you type your search terms. This feature is based on PubMed query log analysis described in " Finding Query Suggestions for PubMed ."
• A spell checking feature suggests alternative spellings for search terms that may include misspellings.
• A citation sensor displays suggested results for searches that include terms characteristic of citation searchinge.g.author namesjournal titles, publication datesand article titles.

I retrieved too many citations. How can I focus my search?

To limit the number of search results: 

• Replace general search terms with more specific ones (e.g.low back pain instead of back pain).
• Include additional terms in your query.
• Use the sidebar filters to restrict results by publication datefull text availabilityarticle typeand more.

I retrieved too few citations. How can I expand my search?

• On the abstract page for a citationsee the Similar Articles section for a pre-calculated set of additional PubMed citations closely related to that article.
• Remove extraneous or specific terms from the search box.
• Try using alternative terms to describe the concepts you are searching.

Find a specific citation

Paste the article title into the search boxor enter citation details such as the authorjournal name and the year the article was published in the search box and the PubMed citation sensor will automatically analyze your query for citation information to return the correct citation. The citation sensor incorporates a fuzzy matching algorithm and will retrieve the best match even if a search includes an incorrect term. You do not need to use field tags or Boolean operators.

Searching by author

Enter the author’s last name and initials without punctuation in the search boxand click Search. 

If you only know the author’s last nameuse the author search field tag [au]e.g., brody[au]. 

Names entered using either the lastname+initials format (e.g.smith ja) or the full name format (john a smith) and no search tag are searched as authors as well as collaboratorsif they exist in PubMed.

Enter a full author name in natural or inverted ordere.g.julia s wong or wong julia s.

• Prior to 2002full author names were not included on PubMed citationsso full author name searches will only retrieve citations from 2002 forwardwhen the full author name was published in the article. 
• A comma following the last name for searching is optional. For some nameshowever, it is necessary to distinguish which name is the last name by using the comma following the last namee.g.jamesryan.

Omit periods after initials and put all suffixes at the ende.g.vollmer charles jr

Initials and suffixes are not required. If you include a middle initial or suffixyou will only retrieve citations for articles that were published using the middle initial or suffix.

More information about author searching:

• To search by author using the search builderclick Advanced search and then select Author from the All Fields menu. The author search box includes an autocomplete feature.
• You may click an author link on the abstract display to execute a search for the author in PubMed. Results will display using a ranking algorithm if the author name is computationally similar for additional PubMed citations.
• If an author name includes only stopwordsuse the author search field tag [au] to search in combination with other termse.g.just by[au] seizure.
• Author names are automatically truncated to account for varying initials and designations such as Jr. To turn off the truncationuse double quotes around the author's name with the author search field tag [au]e.g."smith j"[au].
• Use the search field tag [1au] to search for the first personal author or [lastau] to search for the last personal author name in a citation.

For additional information on author names in PubMed, please see the journal article, "Author Name Disambiguation for PubMed."

Searching by journal

Enter one of the following in the search box:

• full journal title (e.g.molecular biology of the cell)
• title abbreviation (e.g.mol biol cell)
• ISSN numbera standardized international code (e.g.1059-1524)

More information about journal searching: 

• To search by journal using the search builder, click Advanced search and then select Journal from the All Fields menu. The journal search box includes an autocomplete feature.
• To find full journal namesuse the NLM Catalogor mouseover the journal title abbreviation on the citation (available in abstract view).
  1. Click Journals in NCBI Databases on the PubMed homepage.
  2. Enter the journal name and click Search.
• Use the journal search field tag [ta] to limit your search to the journal only, e.g.gene therapy[ta]scanning[ta]
• Searching with the full journal title or abbreviation is recommended for complete retrieval of indexed items; older citations may not have an ISSN.
• If a journal title or abbreviation includes a special character (e.g.parentheses, brackets&)enter the title or abbreviation without the special characters. For exampleto search by the journal abbreviation j hand surg [am]enter j hand surg am.
• Searching for a journal will automatically map to the official journal title and the title associated with an alternative titleif one exists. To turn off this automatic mapping enter the journal in double quotes and tag with [ta]e.g., "science"[ta].

A list of journals included in PubMed is available by FTP.

Searching by date

• Using the results timeline
• Using the search builder
• Searching by a single date in the search box
• Searching for a date range in the search box
• Searching for a relative date range

Using the results timeline

Click and drag the sliders on the Publication Date timeline to change the date range for your search.

Note: The Publication Date timeline counts all publication dates for a citation as supplied by the publishere.g.print and electronic publication dates. These dates may span more than one year; for examplean article that was published online in November 2018 and published in a print issue in January 2019. This means the sum of results represented in the timeline may differ from the search results count.

Using the search builder

1. Click Advanced search and use the search builder.
2. Select a date field from the All Fields menue.g.Date – Publicationand enter a single date or a date range in the fill-in-the-blank boxes. Month and day are optional. If you want to search for a date range up to the current datedo not edit the ‘Present’ date box.
3. Add the date from the builder to the query box.
4. Once you have finished adding terms to the query boxclick Search (or Add to History) to run the search.

Searching by a single date in the search box

Enter dates using the format yyyy/mm/dd [date field]. The month and day are optional.

Use a Boolean operator when combining a date with other search terms.

The available date fields are:

• Date of Publication [dp] - Includes both print and electronic dates of publication except for electronic publication dates occurring after the print publication date.
• Electronic Date of Publication (if applicable) [epdat]
• Print Date of Publication (if applicable) [ppdat]
• Entry Date [edat] - Date used for PubMed processingsuch as “Most Recent” sort order.
• MeSH Date [mhda] - The date the citation was indexed with MeSH terms.
• Create Date [crdt] - The date the PubMed record was first created.

Searching for a date range in the search box

Enter date ranges using a colon (:) between each date followed by a [date field].

Use a Boolean operator when combining a date range with other search terms.

Date range searching includes both print and electronic dates of publicationexcept for electronic publication dates occurring after the print publication date.

Searching for a relative date range

Use the following format to search for a relative date range:

• term="last X days"[date field]
• term="last X months"[date field]
• term="last X years"[date field]

where X is the number of daysmonths or years immediately preceding today’s date and [date field] is the date field tag: [dp][edat] or [crdt].

The relative date range search for publication dates will also include citations with publication dates after today's date; thereforecitations with publication dates in the future will be included in the results.

Filters

You can use filters to narrow your search results by publication date, text availability, article attribute, article type, article language, species sex age, and other.

To apply a filter:

1. Run a search in PubMed.
2. Click the filter you would like to activate from the sidebar. A check mark will appear next to the activated filter(s). 
3. Subsequent searches will be filtered until the selected filters are turned offor until your browser data is cleared.
4. A green "Filters applied" message will display at the top of the results page when filters are applied to your search.

The most frequently used filters appear on the sidebar by default. More filters are available for some categories:

1. Click the "See all … filters" link for a filter category.
2. A pop-up menu will appear showing all available filters for that category.
3. Select the filter(s) you would like to apply to your search.
   • To cancel your selectionsclick Cancel or click on the X in the upper right corner to close the pop-up and return to your search results.
4. Click Apply. This will close the pop-up menuapply the selected filter(s) to your searchand display your selection(s) on the sidebar.
   • The selected filter(s) will appear on the sidebar in addition to the default filters until your browser cookies are clearedor you click the "Reset filters display" button at the bottom of the sidebar.

Clearing applied filters:

• To turn off all currently applied filtersclick the "Clear filters" link in the green "Filters applied" message at the top of the pageor click the "Clear all filters" button at the bottom of the sidebar.
• To turn off individual filtersclick the filter on the sidebar.
• To reset the filters shown on the sidebar to the default filter listclick the "Reset filters display" button at the bottom of the sidebar. This will also clear any currently applied filters.

More information about filters:

• Many filters under the Additional Filters section limit your search results to citations that have been assigned specific MeSH terms during MEDLINE indexing. This means these filters may exclude some otherwise relevant results that do not include the associated MeSH terms.
• See Filter search strategies for the equivalent PubMed query for each filter.
• You can activate additional filters with My Custom filters. Once activated these filters will appear at the top of your sidebar under "My Custom Filters".

Publication date filters

To filter your results by Publication Dateclick 1 year5 years10 yearsor enter a custom range. The 1 year5 yearsand 10 years filters search for a relative date range based on today's date.  

Publication Date filters include both electronic and print publication dates.

Text availability filters

To filter your results to only citations that include a link to full texta link to free full textor an abstractclick the appropriate selections.

Alternativelyyou may search for citations with links to full textfree full text or include an abstract using the values: full text[sb]free full text[sb]or 'hasabstract'. No search field tag is required for hasabstract. You may also search for all citations with a structured abstract with ‘hasstructuredabstract’.

Note: Most citations in PubMed to articles published before 1975 do not include abstracts.

Article attribute filter

Use the associated data filter to find citations that include secondary source databanks and accession numbers. These data links connect to records in other NLM databases (for example: GenBankClinicalTrials.gov) or external data repositories (for example: figshareDryad). Data links are provided by the publisher and/or by data repositories through participation in NCBI’s LinkOut service.

Article type filters

Use article type filters to narrow your results based on the content or of the article such as: Clinical Trial or Review. Article types are also called publication types.

You can add more article type filters to the sidebar using the "See all article type filters" link. The complete list of publication types found in PubMed is available.

Article type filters rely on citations' Publication Type [pt] data except for the Systematic Review filterwhich uses a search strategy in addition to the publication type.

Publication type data may be supplied by the publisher or assigned during the MEDLINE indexing process. Thereforethese filters may exclude some citations that have not yet completed the MEDLINE indexing process.

Systematic reviews

To search for systematic reviews in PubMeduse the Systematic Review article type filter on the sidebaror enter your search terms followed by AND systematic[sb] in the search box. For examplelyme disease AND systematic[sb].

The Systematic Review filter uses a search strategy in addition to the Systematic Review publication type [pt] to find systematic reviews in PubMed. To limit your search to only those citations with the Systematic Review publication typeuse the publication type search tag[pt]i.e.systematic review[pt]; howeverthis may exclude some relevant citations that have not yet completed the MEDLINE indexing process.

Article language filters

Language filters restrict your search to articles published in the selected language(s). You can add more language filters to the sidebar using the "See all article language filters" link.

By defaultPubMed displays English language titles and abstracts when provided by the publisher. Check the Abstract display for links to view the abstract in other languages (when available).

Article language filters are located under the Additional Filters section.

Species filters

Species filters restrict your results to human or animal studies:

• Humans
• Other Animals

Species filters limit your search results to citations that were assigned the associated MeSH terms for species during MEDLINE indexing. These filters will typically deliver precise results but can also exclude some otherwise relevant results that do not include the associated MeSH terms on their PubMed record. For examplesome citations are not indexed for MEDLINEsuch as preprintsOnline Ahead of Print citationsand U.S. government-funded research published in journals that are not indexed for MEDLINE.

Species filters are located under the Additional Filters section.

Sex filters

Sex filters restrict your search results to a specific sex for an animal or human study:

• Female
• Male

Sex filters limit your search results to citations that were assigned the associated MeSH terms for sex during MEDLINE indexing. These filters will typically deliver precise results but can also exclude some otherwise relevant results that do not include the associated MeSH terms on their PubMed record. For examplesome citations are not indexed for MEDLINEsuch as preprintsOnline Ahead of Print citationsand U.S. government-funded research published in journals that are not indexed for MEDLINE.

Sex filters are located under the Additional Filters section.

Age filters

Age filters restrict results to a specific age group for a human study.

Age filters limit your search results to citations that were assigned the associated MeSH terms for age during MEDLINE indexing. These filters will typically deliver precise results but can also exclude some otherwise relevant results that do not include the associated MeSH terms on their PubMed record. For examplesome citations are not indexed for MEDLINEsuch as preprintsOnline Ahead of Print citationsand U.S. government-funded research published in journals that are not indexed for MEDLINE.

Age filters are located under the Additional Filters section. You can add more age filters to the sidebar using the "See all age filters" link.

Age filters include:

• Child: birth-18 years
• Newborn: birth-1 month
• Infant: birth-23 months
• Infant: 1-23 months
• Preschool Child: 2-5 years
• Child: 6-12 years
• Adolescent: 13-18 years
• Adult: 19+ years
• Young Adult: 19-24 years
• Adult: 19-44 years
• Middle Aged + Aged: 45+ years
• Middle Aged: 45-64 years
• Aged: 65+ years
• 80 and over: 80+ years

Other filters & more subsets

Exclude preprints

The Exclude preprints filter will exclude preprint citations from your search results. Alternativelyyou can exclude preprints from your search results by including NOT preprint[pt] at the end of your query.

See Preprints for more information about preprint citations in PubMed.

The Exclude preprints filter is located under the Additional Filters section.

MEDLINE Subset

The MEDLINE filter limits results to citations that are indexed for MEDLINE. To use this filter in a queryadd medline[sb] to your search.

The MEDLINE filter is located under the Additional Filters section.

PubMed Central Subset

To restrict retrieval to citations that have a free full text article available in PubMed Central (PMC)search "pubmed pmc"[sb].

Use the PMID/PMCID/NIHMSID Converter to convert IDs for publications referenced in PubMed and PMC. To retrieve citations that include an NIHMS ID use the queryhasnihmsid.

Citation Status Subsets

The citation status indicates the internal processing stage of an article in the PubMed database (see PubMed Citation Status Subsets).

To search for a particular citation statusenter one of the search terms below followed by the [sb] search tag:

• publisher
• inprocess
• medline
• pubmednotmedline

To search for the total number of PubMed citationsenter all[sb] in the search box.

Ahead of Print Citations

Publishers may submit citations for articles that appear on the web prior to their publication in final or print format. To search for these ahead-of-print citations, enter pubstatusaheadofprint.

Searching for a phrase

Many phrases are recognized by the subject translation table used in PubMed's Automatic Term Mapping (ATM). For exampleif you enter fever of unknown originPubMed recognizes this phrase as a MeSH Term.

You can bypass ATM and search for a specific phrase using the following formats:

• Enclose the phrase in double quotes: "kidney allograft"
  • If you use quotes and the phrase is not found in the phrase indexthe quotes are ignored and the terms are processed using automatic term mapping. The message "Quoted phrase not found in phrase index" will display at the top of your search results.
• Use a search tag: kidney allograft[tw]
  • If you use a search tag and the phrase is not found in the phrase index, the phrase will be broken into separate terms. For example"psittacine flight" is not in the phrase indexso a search for psittacine flight[tw] is broken up and translated as: ((("psittaciformes"[MeSH Terms] OR "psittaciformes"[All Fields]) OR "psittacine"[All Fields]) OR "psittacines"[All Fields]) AND "flight"[Text Word]
  • Terms tagged with [All] are processed using Automatic Term Mapping (ATM). This means phrases tagged with [All] matching a MeSH term or entry term will also include those terms in the search translation. If you want to prevent such mapping put the phrase inside double quotes: "heart attack"[All]
• Use a hyphen: kidney-allograft
  • If you use a hyphen and the phrase is not found in the phrase indexthe search will not return any results for that phrase.
  • Hyphenated phrases matching a MeSH term or entry term will include those terms in the search translation. If you want to prevent such mappingput the hyphenated phrase inside double quotes: "heart-attack"

When you enter search terms as a phrasePubMed will not perform automatic term mapping that includes the MeSH term and any specific terms indented under that term in the MeSH hierarchy. For example"health planning" will include citations that are indexed to the MeSH termHealth Planningbut will not include the more specific termse.g.Health Care RationingHealth Care ReformHealth Plan Implementationthat are included in the automatic MeSH mapping.

Phrase index

PubMed uses a phrase index to provide phrase searching. To browse the phrase indexuse the Show Index feature included in the Advanced Search builder: select a search fieldenter the beginning of a phraseand then click Show Index.

Quoted phrase not found

Phrases may appear in a PubMed record but not be in the phrase index. To search for a phrase that is not found in the phrase indexuse a proximity search with a distance of 0 (e.g. "cognitive impairment in multiple sclerosis"[tiab:~0]); this will search for the quoted terms appearing next to each otherin any order.

Automated processes regularly add new phrases to the index based on standard criteria such as phrase frequency and length. If you would like to request a phrase be added to the phrase indexplease write to the NLM Help Desk.

Wildcards and truncation

To create a wildcard search in PubMeduse an asterisk (*) to substitute for 0 or more characters in a term or phrase. For example "vaccin* schedul*" will find results that include "vaccine schedule""vaccine scheduling""vaccination schedules" and more variations of this phrase.  

• A wildcard (*) substitutes for 0 or more characters
• Terms must begin with at least 4 characters before the first wildcard: colo*
• Multiple wildcards can be used in the same term: organi*ation*

To use wildcards in a phrase searchuse any of the following formats:

• Enclose the phrase in double quotes: "breast feed*"
• Use a search tag: breast feed*[tiab]
• Use a hyphen: breast-feed* 

Phrases can include more than one wildcard: "colo* cancer*"

Wildcards turn off Automatic Term Mapping (ATM) and the process that includes the MeSH term and any specific terms indented under that term in the MeSH hierarchy. For example, "heart attack*" will not map to the MeSH term Myocardial Infarction or include any of the more specific termse.g.Myocardial Stunning; ShockCardiogenic.

Wildcards can be particularly useful to capture variations of a phrasesince phrase searches already turn off automatic term mapping and do not otherwise include alternate spellings or singular/plural forms. For examplesearching for "tumo*r associated macrophage*" retrieves variations of the phrase such as: "tumor associated macrophage""tumour associated macrophage""tumor associated macrophages"and "tumour associated macrophages".

Combining search terms with Boolean operators (ANDORNOT)

PubMed applies an AND operator between conceptse.g."vitamin c common cold" is translated as vitamin c AND common cold. Enter Boolean operators in uppercase characters to combine or exclude search terms:

• AND retrieves results that include all the search terms.
• OR retrieves results that include at least one of the search terms.
• NOT excludes the retrieval of terms from your search.

PubMed processes searches in a left-to-right sequence. Use parentheses to "nest" concepts that should be processed as a unit and then incorporated into the overall search.

• PubMed uses automatic term mapping to identify concepts. For examplefor the search air bladder fistulaPubMed will search "air bladder" as a phrase. If you do not want this automatic phrase parsingenter each term separated by the Boolean operator ANDe.g.air AND bladder AND fistula.
• Search Details show how a search was translated.

Using search field tags

You can search for a term in a specific field by including a search field tag after the term; for exampleUCLA[ad] will search for the term “UCLA” in the affiliation field only.

More information about using search field tags:

• The search field tag must be enclosed in square brackets.
• Case and spacing do not matter: crabs [mh] = Crabs[mh].
• Search field tags turn off Automatic Term Mapping (ATM) limiting your search to the specified term only.
• Using a search field tag after multiple terms will attempt to search those terms as a phrase: kidney allograft[tiab].
• To search multiple terms in the same fieldeach term must be tagged individually: covid-19[ti] vaccine[ti] children[ti].
• The Advanced Search builder can help you search for terms in specific fields and build largecomplex search strings.

Search field tags

Proximity searching

You can use proximity searching to search for multiple terms appearing in any order within a specified distance of one another in the [Title][Title/Abstract]or [Affiliation] fields.

To create a proximity search in PubMedenter your terms using the following format:

"search terms"[field:~N]

• Search terms = Two or more words enclosed in double quotes.
  • There is no limit to the number of words you can search together in proximity; howeverthe more terms you enterthe more restrictive your search becomes. Using the Boolean operator AND to combine terms may be more appropriate than combining many terms into one proximity search.
• Field = The search field tag for [Title][Title/Abstract]or [Affiliation] fields.
  • Proximity searching is only available in the Title Title/Abstractand Affiliation search fields.
  • You can use the full search field tags [Title][Title/Abstract]and [Affiliation]or the abbreviated versions [ti][tiab]and [ad].
• N = The maximum number of words appearing between your search terms.
  • What N value to use will depend on your search. Try changing the N value and comparing the results to find what works best for your search.
  • A higher N creates a broadermore comprehensive search; this will typically retrieve more results overallbut some of these results may be less relevant. Using the Boolean operator AND to combine terms may be more appropriate than proximity searching with a large N value.
  • A lower N creates a narrowermore precise search; this will typically retrieve fewer results that are highly relevantbut may exclude other relevant results.
  • If N=0the quoted terms will appear next to each other--with no other words in between.
  • For the affiliation field onlyan N value of 1,000 or less will search for the double quoted terms together within the same affiliationrather than spread across all affiliations on the record. See Affiliation [ad] for an example proximity search in the affiliation field and more information about searching for affiliations.

More information about proximity searching:

• Results will include your quoted terms in any order. If you would like to search for an exact phrase with terms appearing in a specific orderuse a phrase search instead.
• Automatic Term Mapping is not applied to the quoted terms.
• Proximity searching is not compatible with wildcards (*). If the double quoted terms in a proximity search include a wildcard (*)the proximity operator will be ignored.
• You can combine proximity searches with other terms using Boolean operators; for example"hip pain"[Title:~4] AND stretching
• Booleans and stopwords included in quoted terms for proximity search are searched like regular keywords.

DisplaySortand Navigate

• Understanding your search results
• Display an abstract
• Changing the display format of search results
• Showing more results
• Sorting your results
• Finding the full text article
• Figures
• Similar articles
• Cited by
• References
• Grants and funding
• Navigating searches with more than 10,000 results
• Discovering related data in NCBI databases
• Find related resources using LinkOut
• Reporting broken or problem links

Understanding your search results

Citations are initially displayed 10 items per page and sorted by Best Match.

By defaultPubMed search results are displayed in a summary format and include snippets from the citation abstract. Snippets and highlighted terms are selected based on relatedness to your query.

To see the abstract for an individual citationclick the title of the citation to go to its abstract page.

Journal names are shown using the journal title abbreviation. When viewing citations in Abstract formatyou can mouseover a journal’s title abbreviation to display the full journal name.

Display an abstract

Click the title of the citation to go to its abstract pageor change the search results display to Abstract format using the Display options button in the upper right corner of the search results page.

PubMed may include non-English abstracts if supplied by the publisher. The abstract text defaults to English when a citation has an accompanying non-English abstract. Links to display the additional language(s) are available on the Abstract display. To retrieve citations with non-English abstracts use the query hasnonenglishabstract.

Changing the display format of search results

Results are displayed in the summary format by defaultexcept a single citation result will go directly to the abstract page. You can change the results format using the Display options button:

1. Click the Display options button in the upper right corner of the search results page
2. Select the display format you would like to use
3. Results will be displayed in the new format

Selecting one or more items and changing the display format will display only the selected result(s) in the new format.

By defaultthe summary format includes snippets from the citation abstract. You can turn off snippets under Display options by deselecting Abstract snippets.

Additional display preferences are available when logged into My NCBIsuch as choosing a highlighting color or automatically displaying search results in Abstract format. Please see our online help for more information:

• My NCBI Help: Using Preferences
• My NCBI Help: What is My NCBI?

Showing more results

The results page indicates the total number of items retrieved.

Ten items are displayed per page by default. You can change the number of items displayed per page using the Display options button:

1. Click the Display options button in the upper right corner of the search results page
2. Select the number of items to display per page: 102050100or 200
3. Your selection will be active for subsequent searches until your browser cookies are cleared.

Click "Show more" to display the next page of resultsor click "Jump to page" to navigate directly to a specific page of results. 

Sorting your results

The default sort order in PubMed is Best Match. You can use the "Sort by" drop-down menu at the top of the search results page to change the sort order.

If you change the sort orderyour new selection will be active for subsequent searches until your browser cookies are cleared.

Sort orders

You can sort your search results by:

• Best Match: The Best Match sort order is based on an algorithm that analyzes each PubMed citation found with your search terms. For each search query"weight" is calculated for citations depending on how many search terms are found and in which fields they are found. In additionrecently-published articles are given a somewhat higher weight for sorting. The top articles returned by the weighted term frequency algorithm above are then re-ranked for better relevance by a new machine-learning algorithm. Please see the Algorithm for finding best matching citations in PubMed for more information.
• Most Recent: Citations sorted by Most Recent are displayed in reverse date added order: last infirst out. The Most Recent date is the date a record was initially added to PubMednot the publication date. The secondary sort is PMID.
• Publication Date: Citations sorted by Publication Date are displayed in reverse chronological order: newest to oldest. Citations with more than one publication date, such as electronic and printare sorted by their earliest publication date. Publication dates without a month are set to Januarymultiple months (e.g.Oct-Dec) are set to the first monthand dates without a day are set to the first day of the month. Dates with a season are set as: winter = Januaryspring = Aprilsummer = July and fall = October.
• First Author: Citations are sorted alphabetically by first author name. The secondary sort order within a group with the same first author is PMID.
• Journal: Citations are sorted alphabetically by journal name. The secondary sort order within a group with the same journal name is PMID.

Reverse sort order

• When sorting by Most RecentPublication DateFirst Authoror Journalyou can reverse the sort order by clicking the up/down arrow next to the selected sort option to toggle between ascending or descending order.
• The reverse sort option will not display when Best Match sort order is selected.

Computed author sort

Clicking an author name link on the abstract display runs a search for the author in PubMed. If an author name is computationally similar with an author name for additional PubMed citationsthe results will display those citations firstin ranked orderfollowed by the non-similar citations. Author name disambiguation details are available in Liu W and Wilbur WJ.

Finding the full text article

PubMed records contain citation information (e.g.titleauthorsjournalpublication date) and abstracts of published articles and books. PubMed search results do not include the full text of the journal articlebut the abstract view in PubMed includes links to the full text from other sources when availablesuch as the publisher’s website or the PubMed Central (PMC) database. The full text journal site may require a fee or subscriptionhowever online journals sometimes provide free access. Access may also be available through your organizationor local medical library.

You may be able to obtain free copies of full text articles in these ways:

Free full text filter

On the filter sidebarclick "Free full text" to narrow results to resources that are available for free on the webincluding PubMed CentralBookshelfand publishers' websites. Alternatelyinclude free full text[Filter] in your query.

PubMed Central

When full text is available in PubMed Central (PMC)the "Free in PMC" icon will appear on the citation's abstract display under Full Text Links. Click the icon to view the article in PMC.

PubMed Central (PMC) is the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature.

From the publisher

Journal publishers or related organizations may provide access to articles for freefor free after registering as an individual or guestor for a fee. When provided by the publisher or other organizationicons linking to these sources can be found on the citation's abstract display under the "Full Text Links" and/or "LinkOut" sections. Icons will often indicate free full text when the article is available for free.

Note: When you click a full text icon or link in PubMedyou leave PubMed and are directed to the full text at an external provider's site. NCBI does not hold the copyright to this materialand cannot give permission for its use. Users should review all copyright restrictions set forth by the full text provider before reproducing, redistributingor making commercial use of material accessed through LinkOut.

Please see the Copyright and Disclaimers page for additional information.

If you are affiliated with a hospitaluniversityor other institution

Your local medical library is your best option. If you see icons for your library on the abstract view this indicates that your library provides a link to the articlehas the journal in its collectionor may otherwise obtain the article for you through interlibrary loan. If your library does not have access to the article you needask a librarian about ordering the article from another institution.

Local library

Some local libraries have copies of medical journals or can get a copy of an article for you. Ask your local librarian about inter-library loan options and fees.

Figures

PubMed abstracts include figures when the full text article is available in PubMed Central (PMC). Click the thumbnail to view a larger version of the imagecaptionand link to the figure and copyright information in PMC. Figures correspond to the article version archived in PMCwhich in some cases may be the Author Manuscript version.

Similar articles

The abstract page for a citation includes links to PubMed citations for similar articles. The "See all similar articles" link will retrieve a pre-calculated set of PubMed citations that are closely related to the selected article:

• Similar articles are displayed in ranked order from most to least relevantwith the "linked from" citation displayed first.
• Similar articles are generated by comparing words from the titleabstractand MeSH terms using a word-weighted algorithm.
• Filters are not activated for similar articles.
• You can refine the list of similar articles using your search Historywhere the similar articles retrieval is represented as a list of PMIDs. Use this search number in a search. Refining the list removes the ranked order and may remove citations that are most relevant.

See Computation of similar articles for more information.

Cited by

PubMed abstracts include links to other publications citing the current item. For items with more than 5 citing publications linked in PubMeda "See all 'cited by' articles" link will retrieve the list of citing publications with the cited article displayed as the first result.

"Cited by" is generated using data submitted by publishers and from NCBI resourceswhen available. "Cited by" may not be a complete list of works citing a particular item.

References

PubMed abstracts include references when available. Reference lists are available for citations to full text articles included in the open access subset of PMC and for citations where the publisher supplied references in the citation data sent to PubMed.

Grants and funding

PubMed displays grant numberscontract numbersand intramural research identifiers that have been associated with a publication by:

1. Publishers when depositing data in PubMed and PubMed Central;
2. An authorprincipal investigatoror project director when:
   • depositing a manuscript through the NIH Manuscript Submission (NIHMS) or Europe PMC Plus system; or
   • when adding a publication to My Bibliography; and/or
3. NLM text mining and indexing processes.

A grant award or contract may be acknowledged in an article andthereforedisplayed in PubMed for various reasonsincluding support for activities that contributed directly to the publication as well as support for the generation of an underlying dataset or another shared resource. Additionallysome articles may not explicitly acknowledge intramural research supportyet the authors may be affiliated with a funding agency and may have associated their intramural support with a PubMed record at the time of manuscript deposit to PMC.

Funding information in PubMed is collected in or converted to a standardized format when possible to enable broad discovery and impact monitoring. For exampleif a publication acknowledges support from NIH grant number 1R01 GM987654-01-A1 or GM987654 or ROI GM987654 in a publicationin PubMed the funding information would be normalized to R01 GM987654consistent with NIH requirements for proper grant number format. Funding associations made in a manuscript submissiongrant reportingor indexing system use standardized project identifiers provided to NLM by the organization administering the funding. To learn about searching funding informationsee the search field section on Grants and funding [gr].

The scope of funding information included in PubMed has expanded over time to support the public access policies of NIH and other funding organizations. Since 1981NLM has included grant or contract numbers or both that designate financial support by any agency of the United States Public Health Service (PHS)including NIH. Until 2000only up to three grant numbers were included. Beginning in March 2006funding information was expanded in PubMed to include grantcontractand intramural funding assertions made in NIHMS and My Bibliography to support the NIH Public Access Policy. Publishers have been able to supply funding information directly to PubMed since January 2017.

Reporting funding information errors

Some publications may be inadvertently linked to the wrong funding information. For example the association of a publication to NIH-funded extramural research requires that the author(s) acknowledge NIH support in the article and that the acknowledgement be in a form that can be readily associated with a specific grant or contract. Variations in the format used to cite NIH funding may lead to either an inability to make an association or erroneous matches of publications to grants and contracts.

If you identify an error in funding information associated with a PubMed recordplease contact the NLM help desk. NLM will not remove funding associations that reflect the acknowledged funding in the article without a published correction to ensure alignment with the scientific record. If an award association was provided by the authorprincipal investigatoror project director in My Bibliography or the NIHMS for formal NIH progress and public access compliance reportingremoving the association requires the principal investigator be notified and confirm the lack of direct support.

Navigating searches with more than 10,000 results

PubMed can display up to 10,000 results. The following options can help you navigate searches with more than 10,000 results:

• Reverse the sort order to see the last results first.
• Divide the result set into smaller chunks using the results timeline or custom date range filter.
• Adjust your search to retrieve fewer results.
• For programmatic use and bulk downloadsPubMed data is available via FTP.

Discovering related data in NCBI databases

When availablelinks to other related NCBI databases are included on a citation's Abstract page under the Related information section. The complete list of database options is provided in Entrez Link Descriptions.

MEDLINE indexed citations include additional supplemental information on the Abstract page such as MeSH termspublication typesand substances with links to search for these data in PubMed and the MeSH Database.

To simultaneously search all NCBI databasesuse the NCBI Search page.

Find related resources using LinkOut

Most PubMed records include LinkOut resources to a variety of websites including publishersaggregators, librariesbiological databasesand sequence centers. LinkOut resources link to providers’ sites to obtain the full text of articles or related informatione.g., consumer health. There may be a charge to access the text or information from a provider's site.

To view LinkOut resourcesnavigate to the LinkOut section at the end of an individual citation's abstract page.

To find citations with links to free full text articlesapply the "Free full text" filter to your search results.

To find citations with links to full text articlesenter search terms followed by AND full text[sb].

More information about Links:

• LinkOut resource categories such as "free full text" have been selected by the LinkOut provider.
• The current list of LinkOut providers is available.
• A publisher's icon link may display on the abstract format if they have electronically provided their citation data to NCBI. Links are only available for publishers that are participating in LinkOut; publishers are responsible for providing working links.

Reporting broken or problem links

LinkOut links are supplied by the LinkOut providers. Publishers who electronically supply their data to PubMed may include an icon that links to a site providing the full text. Corrections and changes to links are made by the providers and are their responsibility.

To report problem links or inquire about online journal subscriptionscontact the provider directly. Contact information is typically available at a provider's web site.

CiteSaveand Share

• Save citations temporarily using the Clipboard
• Save citations indefinitely using My NCBI Collections
• Save citations as a text file
• Cite an article
• Export citations into citation management software
• Email citations
• Create an email alert for a search
• Create an RSS feed for a search
• Print your search results
• Get a permalink to bookmark or share your search
• Download PubMed data

Save citations temporarily using the Clipboard

The Clipboard provides a place to collect up to 500 items from one or more searches. Items saved to the Clipboard are stored in your browser cookies and will expire after 8 hours of inactivity. If you would like to save items for longer than 8 hours or to view on another deviceplease use Send to: Collections.

To add items to the Clipboard:

1. Use the check boxes to select items from your search results. To save all results (up to a maximum of 500)do not tick any check boxes.
2. Use the Send to button and choose Clipboard.
3. Selected items will be added to the Clipboard.
   • If no items were selecteda drop-down menu of options will display where you may add selected itemsall results on the pageor all results (up to a maximum limit of 500 citations) to the Clipboard.
   • An individual item can also be added to the Clipboard from its abstract page.
4. To view your selectionsclick the Clipboard link under the Search bar. This link will only appear after one or more items have been added to the Clipboard; the link is not present when the Clipboard is empty.

To delete items from the Clipboard:

• On the Clipboard pageclick "Remove from Clipboard" below each item to delete the item from the Clipboard.
• Select one or more items using the check boxes next to each itemthen click "Remove selected items."
• To delete all items from the Clipboardclick "Remove all."

More information about the Clipboard:

• Citations added to the Clipboard are marked with the message "Item in Clipboard" in search results.
• The maximum number of items that can be sent to the Clipboard is 500. If you select Clipboard from send to without selecting citationsPubMed will add all (up to 500 citations) of your search results to the Clipboard.
• The Clipboard will not add a citation that is currently in the Clipboard; it will not create duplicate entries.
• Your web browser must accept cookies to use the Clipboard.
• Citations in the Clipboard are represented by the search number #0which may be used in Boolean search statements. For exampleto limit the citations you have collected in the Clipboard to English language articlesuse the following search: #0 AND english [la]. This does not affect or replace the Clipboard contents.

Save citations indefinitely using My NCBI Collections

Search results can be saved in My NCBI using the Collections feature. There is no limit to the number of collections you may store in My NCBI. In addition, collections can be made public to share with others.

To save results to a new collection:

1. Sign into My NCBI. Run a search in PubMed.
2. Use the check boxes to select items from your search results or Clipboard. To save all results (up to a maximum of 1,000)do not tick any check boxes.
3. Use the Send to button and choose Collections.
4. Selected items will be added to a Collection.
   • If no items were selecteda drop-down menu of options will display where you may add selected itemsall results on the pageor all results (up to a maximum limit of 1,000 citations) to a Collection.
   • An individual item can also be added to a Collection from its abstract page.
5. Choose Create a new collection.
6. Name your collection using a shortmeaningful title. The name must be unique and less than 100 characters. Identical names for different Collections are not allowed.
7. Click Add to finish.

As you continue to build collectionsyou may want to add new items to an existing collection. To add search results to an existing collection:

1. Follow steps 1 - 4 above. Add to an existing collection will be the default selection.
2. Use the pull-down menu to choose a collection.
3. Click Add to finish.

For more information on viewingsortingeditingmergingsharingand deleting collectionssee Collections in My NCBI Help.

Save citations as a text file

Use the Save button to download citations to a text file.

1. Use the check boxes to select citations from your search results or Clipboard. You may move to other pages to continue your selections. If you do not make any selections, you can choose to save “All results on this page” or “All results” from the Save menu.
2. Click Save and choose a Selection and Format from the menu that appears.
   • Selection: The citations you would like to save.
     • Selection: The number of selected items will be shownfor example: Selection (87).
     • All results on this page
     • All results (up to a maximum of 10,000 citations)
   • Format: Summary (text)PubMedPMID listAbstract (text)or CSV
3. Click Create file.
4. Your web browser will prompt you to save the file on your computer.

More information about saving citations to a file:

• Saving a large set of results may take several minutes.
• To save citations in HTML formatuse the "Save" or "Save as" function of your browser and change the file extension to html. When saving as HTMLonly those citations displayed on the page will be saved; thereforeconsider showing more results.

Cite an article

The Cite button makes it easy to retrieve d citations that you can copy and paste into a documentor download an .nbib file to use with your reference manager software.

Using the Cite button for an item will open a pop-up window where you can copy the citation formatted in four popular s: AMA (American Medical Association)MLA (Modern Language Association)APA (American Psychological Association)or NLM (National Library of Medicine). You can also download the citation as an .nbib filewhich most bibliographic reference management software can import.

Note: In all citation sthere are certain capitalization rules that machines cannot handle. For examplethere is no way to identify proper nounsacronymsabbreviationsetc.that is 100% accurate and complies with all rules at all times. Capitalization of article titles and other citation elements should be checked for compliance with a particular reference when required.

To export multiple citations: follow the instructions for saving citations as a text file and choose the format Summary (text) to save a list of citations in NLM or follow the instructions to export citations into your citation management software program.

Export citations into citation management software

Use Send to: Citation Manager to export citations as an .nbib file that can be used by many citation management programs:

1. Use the check boxes to select citations from your search results or Clipboard. You may move to other pages to continue your selections. Alternatelyyou can choose to save all results on this page or all results from the Send to: Citation Manager menu.
2. Click Send to and choose Citation Manager.
3. Confirm the citations you want to export: selectionall results on this pageor all results (up to a maximum of 10,000).
4. Click Create file.
5. Your web browser will prompt you to save the file on your computer.
6. Import this saved file into your citation management program.

You can also download an .nbib file for individual citations using the Cite button.

Questions regarding citation management software should be directed to the respective companies.

Email citations

1. Use the check boxes to select citations from your search results or Clipboard. You may move to other pages and continue your selections. You may also choose to email all citations shown on the page without making any selections.
2. Click the Email button.
3. Enter an email address. Select which citations to send and the format.
4. Click Send email. The system returns you to your results page and displays a confirmation e-mail sent message.

More information about emailing citations:

• Your citations will be sent from the NCBI automatic mail server with the sender's email address [[email protected]]. Do not reply to this messageas this is not a functioning customer service email address and is not monitored.
• The CAPTCHA image does not display for users who are signed in to My NCBI.

Create an email alert for a search

Click "Create alert" under the search bar to create an automatic email update for searches. You must sign in to My NCBI to use this feature. See Saving and Managing Searches for more information.

Create an RSS feed for a search

Click on Create RSS under the search box at the top of the page to create an RSS feed for your search.

1. The RSS feed name will default to the search terms. You can edit the RSS feed name as needed.
2. Use the pull-down menu to select the number of items displayed. You may manually edit the limit= parameter in the RSS feed link created in Step 4 to display up to a maximum of 1000 items. Please note that increasing this limit will also increase the loading time.
3. Click the Create RSS button.
4. The RSS Feed Link will appear; click on Copy to copy the link.
5. Use this link with your feed reader or other application.

Print your search results

Use the print function of your web browser. To print citations from different searches, save the citations in PubMed’s Clipboardand then print.

See also:

• Showing more results
• Changing the display format

Get a permalink to bookmark or share your search

To get the URL for an individual citation:

• From an abstract pageclick the Permalink button on the right sidebar and click "Copy".
• From the search resultsright click an article title and choose the copy link option; exact wording and functionality may change depending on your operating system and browser.
• From a mobile deviceuse your device’s native share functionality to copy a link.

To get the URL for your search resultscopy the URL from your web browser's address bar or bookmark the URL using your web browser's bookmark function.

To create a URL manually:

1. Use the base URL: https://pubmed.ncbi.nlm.nih.gov/?term=search
2. Replace “search” in the base URL with your query terms
3. Escape spaces by converting them to plus signs (+); for exampleBiochem Soc Trans should be entered as: Biochem+Soc+Trans

The number of characters you can use may be limited by your browser’s maximum URL length (which may be different for each browser).

Optional search parameters:

• format=summaryabstractpubmedpmid
• sort=relevancedatepubdatefauthjour
• sort_order=asc
• size=102050100200

More information about PubMed links:

• Some settings in PubMed rely on cookies and other session data that may not be present in the URL. For examplesearches that were created using a search number in Advanced History (e.g.#1 OR #2 AND human[mh]) cannot be saved using the URL because the search will be lost when your History expires.
• Users intending to send frequent queries or retrieve large numbers of records from the NCBI databases should use E-Utilities. Users must comply with the usage guidelines and requirements to prevent overloading NCBI systems.
• The NCBI Disclaimer and Copyright notice must be evident to users. Users are advised to consult legal counsel to ensure compliance with intellectual property laws. NLM cannot provide advice about copyright issues.

Download PubMed data

Once a yearNLM releases a complete (baseline) set of PubMed citation records in XML format for download from our FTP servers. Incremental update files are released daily and include newrevisedand deleted citations. The PubMed DTD states any changes to the structure and allowed elements from year to year.

Note: Binary mode must be used when downloading data from our FTP servers.

• Documentation: PubMed XML Elements and Attributes
• Terms and Conditions
• PubMed Baseline
• PubMed Update Files
• PubMed DTD

For more informationplease see Download PubMed Data.

Advanced Search

• Searching in a specific field
• Browsing the index of terms
• History
• Previewing the number of search results
• Combining searches using History
• Viewing the Search Details

Tools included on the Advanced Search page help users to: search for terms in a specific fieldcombine searches and build largecomplex search stringssee how each query was translated by PubMedand compare number of results for different queries.

Searching in a specific field

Use the Advanced Search Builder to search for terms in a specific fieldsuch as author or journal. For some fieldsan autocomplete feature will provide suggestions as you type.

1. From the "All Fields" drop-down menuselect the field you would like to search.
2. Add terms from the builder to the query box to construct your search. The default Boolean operator is AND; if desiredchoose OR or NOT from the pull-down menu.
3. Once you have finished adding terms to the query boxclick Search (or Add to History) to run the search.

You may also search a specific field -- and bypass Automatic Term Mapping -- by adding a search field tag to a term.

Browsing the index of terms

The Advanced Search Builder includes the Show Index featurewhich provides an alphabetical display of terms appearing in selected PubMed search fields. You can browse by all fields or within specific fields such as MeSH Terms.

1. Click Advanced to navigate to the Advanced Search pageand use the Builder to select a search field from the All Fields menu. Note: Show Index is not available for every search field. The Show Index link will only display for fields that are compatible with this feature.
2. Enter a term in the search boxthen click Show Index.
3. The index displays an alphabetic list of search terms and the approximate number of citations for each term (the actual citation count is returned when the search is executed).
4. Scroll until you find a term you want to include in your searchand then highlight it to add it to the search box.
5. Multiple terms may be selected from the list and added to the search box.
6. Add terms from the builder to the query box to construct your search.
7. Once you have finished adding terms to the query boxclick Search (or Add to History) to run the search.

More information about using the index:

• PubMed processes all Boolean operators left to right.
• The builder will automatically OR (and add parentheses) for multiple terms selected from the index.
• A slash will display after a space. For examplethe MeSH Term and Subheading "zika virus/analysis" will display after "zika virus infection/virology." Enter MeSH terms followed by a slash to go directly to the display for the MeSH/Subheading combination counts in the index.
• Show Index is not available for date fields.

History

Your PubMed search history appears on the Advanced Search page under History. This feature requires your web browser to accept cookies.

Descriptions of each column in the History table appear below:

• Search: Searches are numbered in chronological order.
  • Search numbers may be used in place of the search string itself when combining queries (e.g.#1 OR #2).
  • A repeated query will move to the top of History but will retain its original numbering.
  • History is limited to the last 100 searches. Once the maximum number is reachedPubMed will remove the oldest search from history and add the most current search.
• Actions: Adddeleteor save a query. Adding queries from History places the search string into the Query box to be used in the next search. Deleting a query removes it from History.
• Query: This column shows previous search strings as entered by the user.
• Details: PubMed may modify or add search terms to a search to optimize retrieval, e.g.using automatic term mapping. Click the chevron icon " > " to expand search details and see how the search was translated.
• Results: The total number of citations retrieved for that query. Click the number to run the search and see the results in PubMed.
• Time: Timestamp of when the search was conducted.
• Download: Click Download to generate a CSV file of current History items.
  • Please noteMicrosoft Excel is typically unable to display or print more than a maximum of 1024 characters in a cell; thereforeyou may want to open the CSV file with a text editor to display your complete searches.
• Delete: Click "Delete" to remove all queries from History; otherwiseHistory expires after 8 hours of inactivity.

Previewing the number of search results

1. Click Advanced to navigate to the Advanced Search page.
2. Use the builder to add search terms to the query boxor type your search directly into the query box.
3. Use the split button to toggle the button function from "Search" to "Add to History".
4. Click Add to History. This will run the search without leaving the Advanced Search page.
5. See your query including the number of results in the History table.

Combining searches using History

Searches can be combined or used in later searches using your search History.

1. Click Advanced to navigate to the Advanced Search page.
2. In the History tableclick the More Actions icon " ... " next to your query.
3. From the available optionsselect "Add query" to copy the query to the Query box.
4. After you've added content to the Query boxoptions to use the Boolean operators ANDORor NOT will appear when adding more queries to the Query box.
5. Edit your query in the Query box if you would like to make any changes before running the search.
6. Click Search (or Add to History).

More information about combining searches from your History:

• Search numbers may be used in place of the search string itself when combining queries (e.g.#1 OR #2).
• Citations in the Clipboard are represented by the search number #0which may be used in searches. For exampleto limit the citations you have collected in the clipboard to English language citationsuse the following search: #0 AND english [la]. This does not change or replace the Clipboard contents.

Viewing the Search Details

PubMed may modify or add additional search terms to your search to optimize retrieval, such as: MeSH termsBritish/American spellingssingular/plural word formsand other synonyms.

1. Search Details are included on the Advanced Search page under History.
2. Click the chevron icon " > " next to a query in History to expand the Search Details. 
3. When expandedthe details below a query in the History table show the search strategy used to run the search.

More information about search details:

• Translations show individual term mappings using PubMed's search rules and syntax. Query terms without translations will not be listed in this section; for example exact phrases bypass Automatic Term Mapping (ATM).
• Warnings are displayed for the original query with potential errors in bold and red typesuch as syntax errorsterms not foundor invalid tags. Warnings also appear as a highlighted message in PubMed when the search is run or added to History.

Other services

• Clinical Queries
• Single Citation Matcher
• Search PubMed using the MeSH database
• Search for journal information in the NLM Catalog
• Using the E-utilities API tools
• Citation Matcher API
• Batch Citation Matcher
• Consumer health

Clinical Queries

PubMed Clinical Queries provides specialized searches for:

• COVID-19 Articles
• Clinical Study Categories
• Medical Genetics

Search for COVID-19 articles

The COVID-19 article filters limit retrieval to citations about the 2019 novel coronavirus. Results are displayed in a column filtered by research topic categories. See COVID-19 article filters for the filter search strategies; these may evolve over time.

To find citations using the COVID-19 article filters:

1. Click Clinical Queries from the PubMed homepage
2. Enter your search terms in the search box
3. Click Search
4. Select a Category: GeneralMechanismTransmissionDiagnosisTreatmentPrevention Case ReportForecastingor Long COVID
5. Preview results in the COVID-19 Articles column
6. To view the results in PubMedclick the "See all" link below the results preview

To use the COVID-19 article filters in a queryadd the filter name to your search with the search field tag [Filter]e.g.LitCPrevention[Filter]. The available filters are:

• LitCGeneral
• LitCMechanism
• LitCTransmission
• LitCDiagnosis
• LitCTreatment
• LitCPrevention
• LitCCaseReport
• LitCForecasting
• LitCLongCOVID

Search by clinical study category

Clinical Study Categories use a specialized search method with built-in search filters that limit retrieval to citations reporting research conducted with specific methodologiesincluding those that report applied clinical research. See Clinical Study Categories filters for the filter search strategies.

To find citations using the Clinical Study Categories:

1. Click Clinical Queries from the PubMed homepage
2. Enter your search terms in the search box
3. Click Search
4. Select a Category: TherapyDiagnosisEtiologyPrognosisor Clinical Prediction Guides
5. Select a Scope: Narrow (specific search) or Broad (sensitive search)
6. Preview results in the Clinical Study Categories column
7. To view the results in PubMedclick the "See all" link below the results preview

Medical genetics searches

The Medical Genetics filters limit retrieval to citations related to various topics in medical genetics. See Medical genetics search filters for the filter search strategies.

To use a Medical Genetics filteradd the filter name to your search with the search field tag [Filter]e.g.Genetic Testing[Filter]. The available filters are:

• Diagnosis
• Differential Diagnosis
• Clinical Description
• Management
• Genetic Counseling
• Molecular Genetics
• Genetic Testing
• Medical Genetics

Single Citation Matcher

The Single Citation Matcher has a fill-in-the-blank form for searching for a citation when you have some bibliographic information such as journal namevolumeor page number.

• Click Single Citation Matcher on the PubMed homepage.
• Enter the citation information.
• Click Go.

More information about using the Single Citation Matcher:

• The journal box includes an autocomplete feature that suggests titles as you enter a title abbreviation or full title. Titles displayed by the autocomplete menu are in ranked order based on the number of citations in PubMed.
• After selecting a journal with special characters (e.g.ampersandcolon) when using the Back button to return to the Single Citation Matcher you must clear and reenter the title.
• The author box also includes an autocomplete feature that suggests author names in ranked order based on the number of citations. Full author names may be searched for citations published from 2002 forward if the full author name is available in the article.
• Click either the 'Only as first author' or ‘Only as last author’ check box to limit an author name to the first or last author.

Search PubMed using the MeSH database

MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing PubMed citations.

Use the MeSH database to find MeSH termsincluding SubheadingsPublication TypesSupplementary Concepts and Pharmacological Actionsand then build a PubMed search. The MeSH database can be searched by MeSH termMeSH Entry TermSubheadingPublication TypeSupplementary Conceptor MeSH Scope Note.

More information about the MeSH database:

• An autocomplete feature is available from the search box.
• Search results are displayed in relevance-ranked orderthereforewhen a user’s search exactly matches a MeSH Termthat Term is displayed first.
• Click the MeSH term from the Summary display or choose Full from the display format menu to view additional information and search specificationssuch as Subheadings, restrict to Major MeSH Topicor exclude terms below the term in the MeSH hierarchy.
• Year Introduced is the year the term was added to MeSH. If more than one year is shownthe term was available for indexing back to the earliest year noted. Articles are indexed using the vocabulary in place at the time of indexingthereforethe year introduced for a term and the date of publication of a citation indexed with that term may not agree.

Launch PubMed searches from the MeSH database

To build a PubMed search from MeSH:

1. Run a search in the MeSH database.
2. Select terms using the check boxes.
3. Click "Add to search builder" in the PubMed search builder portlet.
4. You may continue searching and including additional terms to the PubMed search builder using the "Add to search builder" and Boolean pull-down menu.
5. When you are finishedclick "Search PubMed."

Search for journal information in the NLM Catalog

The NLM Catalog includes information about the journals in PubMed and the other NCBI databases.

Click Journals in NCBI Databases on the homepage of NLM Catalog or the Journals link on the PubMed homepage to limit your NLM Catalog results to the subset of journals that are referenced in NCBI database records.

See the NLM Catalog help for additional information.

Other journal resources include:

• PubMed journals with links to full text
• List of all journals included in PubMed via FTP
• List of Serials Indexed for Online Users

Using the E-utilities API tools

E-utilities are tools that provide access to data outside of the regular NCBI web search interface. This may be helpful for retrieving search results for use in another environment. If you are interested in large-scale data mining on PubMed datayou may download the data for free from our FTP server. Please see the terms and conditions for data users.

Citation Matcher API

• API root
• Fielded search
• Heuristic search
• Auto search
• Rate control

The PubMed Citation Matcher API finds PubMed identifiers (PMIDs) for citation data in structured or raw form. The interface supports three retrieval methods:

1. field - runs a fielded search using core bibliographic informationsuch as journaldateor volume.
2. heuristic - collects all input elements into a single string and returns the closest matching documents.
3. auto - combines the two above methods and switches to heuristic mode if the fielded search has not yielded a result. This is the default method.

More information about the Citation Matcher API:

• The API supports both GET and POST requests.
• Data is exchanged in JSON.
• Input data should be UTF-8 encoded.
• The API returns a maximum of 20 PMIDs; queries returning more than 20 PMIDs are treated as bad requests.

API root

The API root is:

https://pubmed.ncbi.nlm.nih.gov/api/citmatch/

Fielded search

method=field runs a fielded search using core bibliographic information such as journaldateor volume. This functionality is similar to E-utilities ESearch; users should select the API that best suits their needs.

For a structured searchthe following fields can be used:

• journal - the name of the journal
• pdat - the publication datein the format YYYY/MM/DD
• volume - the volume of the publication
• issue - the volume of the publication
• authors - one or more author namesin the format "Surname Initial" (Doe J). Optionallythe position may be specified as firstlastor auto.

/citmatch/?method=field&journal=Front+Immunol&volume=13&page=826091&authors=Ihunwo+A

{
    "citmatch": {
        "method": "field",
        "journal": "Front Immunol",
        "volume": "13",
        "page": "826091",
        "authors": [
            {
                "name": "Ihunwo AO",
                "position": "first"
            }
        ]
    }
}
            

{
    "version": "1.0",
    "operation": "citmatch",
    "success": true,
    "result": {
        "count": 1,
        "type": "uids",
        "uids": [
            {"pubmed": "35251006"}
        ]
    }
}                
            

Heuristic search

method=heuristic collects all input elements into a single string and returns the closest matching documents. It is sufficient to supply a raw citation stringsuch as: "The role of drag in insect hovering. J. Exp. Biol. 2004;207:4147–4155."

/citmatch/?method=heuristic&raw-text=Neurogenesis+and+Viral+Infection.+Front+Immunol.+2022+Feb+17;13:82609.

{
    "citmatch": {
        "method": "heuristic",
        "raw-text": {"text": "Neurogenesis+and+Viral+Infection.+Front+Immunol.+2022+Feb+17;13:82609."}
    }
}
            

{
    "version": "1.0",
    "operation": "citmatch",
    "success": true,
    "result": {
        "count": 1,
        "type": "uids",
        "uids": [
            {"pubmed": "35251006"}
        ]
    }
}              
            

Auto search

method=auto first runs a fielded searchand if no results are foundit combines the fields and runs a heuristic search. This is the default method.

For a structured searchthe following fields can be used:

• journal - the name of the journal
• pdat - the publication datein the format YYYY/MM/DD
• volume - the volume of the publication
• issue - the volume of the publication
• authors - one or more author namesin the format "Surname Initial" (Doe J). Optionallythe position may be specified as firstlastor auto.

Rate control

When using the PubMed Citation Matcher API programmaticallywe request that you limit your application's rate to 3 requests / sec and do not make concurrent requests to this serviceeven at off-peak times. Additionallyrequests must contain the name of the calling project in the User-Agent HTTP header value; e.g. Hydra/1.3.15.

Batch Citation Matcher

Use the Batch Citation Matcher to retrieve PMIDs for multiple citations. The Batch Citation Matcher requires that you enter the bibliographic information (journalvolumepageetc.) in a specific format.

To retrieve PubMed PMIDs:

1. Create citation strings for the items you would like to retrieve using the following format:
   journal_title|year|volume|first_page|author_name|your_key|
   Fields must be separated by a vertical bar with a final bar at the end of the string.
2. Enter your email address. Email messages may take several minutes to process and be sent to your email address.
3. Upload your citation strings as a text file (.txt) or enter each citation string on a separate line in the text box. If citation strings are entered in the text box and a file is uploadedthe results will be an aggregate of both.
4. Click search.

If a match is not found the citation string will display one of the following:

• your_key|NOT_FOUND;INVALID_JOURNAL - The journal name is not valid. See the journal lists or the NLM Catalog to find the correct journal abbreviation.
• NOT_FOUND - The journal name is validbut the citation string did not find a match.
• AMBIGUOUS - The information provided matches more than one citation. Citation information with 3 or fewer matches include the PMIDsand more than 3 matches include the total PMID match count. Use the Single Citation Matcher or ESearch to retrieve all citations for searched fields.

Notes:

• Text (.txt) format must be used when uploading a file.
• You may receive multiple emails for searches containing more than 2,000 citation strings.
• Enter author names without punctuation as smith jc. Initials are optional.
• Your key is any string you choose to tag the citationit is returned unaltered.
• The journal title field may include the full journal title or the NLM title abbreviation.
• Each citation field is searched starting with the journal title until a unique match is found.
• The journal title is a required field however you may omit other fields. If you omit fields you must retain the vertical bars in the citation string. For exampleif you omit the volume number 88 from the first example below it should be entered as:
  proc natl acad sci u s a|1991||3248|mann bj|P32022-1|

Example input:

• proc natl acad sci u s a|1991|88|3248|mann bj|P32022-1|
• proc natl acad sci u s a|1992|89|3271|gould se|P26261-1|
• proc natl acad sci u s a|1970|89|3271|smith|P26261-1|
• res microbiol|1992|143|467|ivey dm|P25966-1|
• science|1987|235|182|palmenberg ac|P12296-2|
• eschatology|1993|12|22|public jq|C12233-2|
• virology|1993|193|492|hardy me|Q02945-1|
• virus genes|1992|6|393||P27423-1|
• yeast|1992|8|253|sasnauskas k|P24813-1|

Example output:

• proc natl acad sci u s a|1991|88|3248|mann bj|P32022-1|2014248
• proc natl acad sci u s a|1992|89|3271|gould se|P26261-1|1565618
• proc natl acad sci u s a|1970|89|3271|smith|P26261-1|NOT_FOUND
• res microbiol|1992|143|467|ivey dm|P25966-1|1448623
• science|1987|235|182|palmenberg ac|P12296-2|3026048
• C12233-2|NOT_FOUND;INVALID_JOURNAL
• virology|1993|193|492|hardy me|Q02945-1|8382410
• virus genes|1992|6|393||P27423-1|1335631
• yeast|1992|8|253|sasnauskas k|P24813-1|1514324

Consumer health

The National Library of Medicine cannot provide specific medical advice. NLM urges you to consult a qualified health care professional for answers to your medical questions. NLM does not have pamphlets or other materials to mail.

MedlinePlus and MedlinePlus en español are specifically designed for consumerscontaining hundreds of topic pages including NIH-written descriptive informationvideoshealth check toolsdrugherb and supplement infolinks to Fact Sheets from other NIH Institutesthe CDCetc.and more.

Appendices

• Further assistance and training
• How PubMed works: Automatic Term Mapping (ATM)
• Algorithm for finding best matching citations in PubMed
• PubMed coverage
• PubMed format
• PubMed data field descriptions
• NLM author indexing policy
• Error messages
• Cookies
• MeSH Subheadings
• Stopwords
• PubMed character conversions
• Publication Types
• Status Subsets
• Filter search strategies
• Clinical Queries filters
• Computation of similar articles
• Journal lists

Further assistance and training

Contact customer support

• E-mail the PubMed Help Desk
• Call the NLM Customer service desk: 1-888-FIND-NLM (1-888-346-3656)

Other NLM publications

• PubMed Online Training
• PubMed Trainer's Toolkit
• NLM Technical Bulletin

How PubMed works: Automatic Term Mapping (ATM)

Untagged terms that are entered in the search box are matched (in this order) against a Subject translation table (including MeSH (Medical Subject Headings))a Journals translation tablethe Author indexand an Investigator (Collaborator) index.

When a match is found for a term or phrase in a translation table the mapping process is complete and does not continue on to the next translation table.

To see how your terms were translatedcheck the Search Details available on the Advanced Search page for each query under History. If you want to report a translation that does not seem accurate for your search topicplease e-mail the information to the NLM Help Desk.

1. Subject translation table

The Subject Translation Table contains:

• British and American spellings
• Pairs: singular and plural word formssynonymsand other closely related terms
• Drug brand name to generic name translations
• MeSH terms
• The See-Reference mappings (also known as entry terms) for MeSH terms
• MeSH Subheadings
• Publication Types
• Pharmacologic action terms
• Terms derived from the Unified Medical Language System (UMLS) that have equivalent synonyms or lexical variants in English
• Supplementary concept (substance) names and their synonyms.

If a match is found in this translation tablethe term will be searched as MeSH (that includes the MeSH term and any specific terms indented under that term in the MeSH hierarchy)and in all fields.

For exampleif you enter child rearing in the search boxPubMed will translate this search to: "child rearing"[MeSH Terms] OR ("child"[All Fields] AND "rearing"[All Fields]) OR "child rearing"[All Fields]

If you enter a MeSH Term that is also a Pharmacologic Action PubMed will search the term as [MeSH Terms][Pharmacologic Action]and [All Fields].

If you enter an entry term for a MeSH term the translation will also include an all fields search for the MeSH term associated with the entry term. For examplea search for odontalgia will translate to: "toothache"[MeSH Terms] OR "toothache"[All Fields] OR "odontalgia"[All Fields] OR "odontalgias"[All Fields] because Odontalgia is an entry term for the MeSH term toothache.

Substance name mappings do not include a mapping for individual terms in a phrasee.g., IL-22 will not include IL[All Fields] AND 22[All Fields].

MeSH term mappings that include a standalone number or single character do not include a mapping for individual terms in a phrasee.g.Protein C will not include Protein[All Fields] or C[All Fields].

2. Journals translation table

The Journals translation table contains the:

• full journal title
• title abbreviation
• ISSN and eISSN number.

These will automatically map to the journal abbreviation that is used to search journals in PubMed and in all fields. For examplea search for endocrine pathology will translate to: "Endocr Pathol"[Journal] OR ("endocrine"[All Fields] AND "pathology"[All Fields]) OR "endocrine pathology"[All Fields]

3. Author index

If the term is not found in the above tablesand is not a single termPubMed checks the author index for a match. The author index includes author names and initialsas well as full author names for articles published from 2002 forwardif available.

More information about author searching:

• PubMed automatically truncates a search for an author's name to account for varying initialse.g., o'brien j retrieves o'brien jao'brien jbo'brien jc jras well as o'brien j.
• When combining multiple authorsto avoid a match with full author namesinclude initials or use the [au] search tage.g.ryan[au] james[au]. Author names comprised of only stopwordse.g., as aare not searched as authors if they are part of phrasechemical burn as a dangerunless the search only includes the author namee.g.as a.
• Enter a full author name in natural or inverted ordere.g.julia s wong or wong julia s.
• A comma following the last name for searching is optional. For some nameshowever, it is necessary to distinguish which name is the last name by using the comma following the last namee.g.jamesryan.
• Omit periods after initials and put all suffixes at the ende.g.vollmer charles jr
• Initials and suffixes are not requiredif you include a middle initial or suffix, you will only retrieve citations for articles that were published using the middle initial or suffix.
• To distinguish author initials that may match a full author name use the [fau] search tage.g.peterson do[fau].

4. Investigator (Collaborator) index

If the term is not found in the above tablesexcept for Authorand is not a single termthe investigator index is consulted for a match. The investigator (collaborator) index includes full namesif available. Enter a full investigator name in natural or inverted ordere.g.harry janes or janes harry.

5. If no match is found?

PubMed breaks apart the phrase and repeats the above automatic term mapping process until a match is found. PubMed ignores stopwords in searches.

If there is no matchthe individual terms will be combined (ANDed) together and searched in all fields.

When a search includes terms that were tagged with a search field during the automatic term mapping process and retrieves zero resultsthe system triggers a subsequent search using "Schema: all ." "Schema: all" modifies the search by removing the automatically added search field tagsand then searches each term in all fields.

Algorithm for finding best matching citations in PubMed

The learned ranking algorithm combines over 150 signals that are helpful for finding best matching results. Most of these signals are computed from the query-document term pairs (e.g.number of term matches between the query and the document) while others are either specific to a document (e.g.publication type; publication year) or query (e.g.query length). The new ranking model was built on relevance data extracted from the anonymous and aggregated PubMed search logs over an extended period of time.

For more information about the Best Match algorithmplease see:

• Technical details in the paper Best Match: New relevance search for PubMed by Fiorini N, Canese KStarchenko Get al. in PLoS Biol (2018).
• NLM Technical Bulletin article: Updated Algorithm for the PubMed Best Match Sort Order

PubMed coverage

The PubMed database contains citations and abstracts to biomedical literaturefacilitating searching across several NLM literature resources:

• MEDLINE
• PubMed Central (PMC)
• NCBI Bookshelf

For additional informationplease see the webpages About PubMed and About NLM's Literature Databases.

PubMed includes citations to original research articlesliterature reviewscase reports letterseditorialscommentariesand other selected publications on scientific and medical topics (see: publication types found in PubMed). Some categories of content are out of scope for PubMedsuch as: book reviewsindividual conference abstracts obituaries and in memoriam articlesnews and announcementsand brief summaries of research articles. More examples are included in XML Help for PubMed Data Providers: What types of articles are accepted?.

MEDLINE

MEDLINE contains citations to journal articles in the life sciences with a concentration on biomedicine. The MEDLINE database contains citations from the late 1940s to the presentwith some older material.

New citations from MEDLINE journals are received electronically from publishers and appear in PubMed daily. Most citations progress to in-processand then to indexed for MEDLINE; however not all citations will be indexed for MEDLINE. PubMed includes some citations from MEDLINE journals that are not indexed for MEDLINEsuch as:

• Citations preceding the date that a journal was selected for MEDLINE indexing.
• Out-of-scope citations (e.g.articles on plate tectonics or astrophysics) from certain MEDLINE journalsprimarily general science and chemistry journalsfor which the life sciences articles are indexed for MEDLINE.

Citations that have been indexed for MEDLINE and updated with NLM Medical Subject Headings (MeSH) publication typesGenBank accession numbersand other indexing data are available daily. To limit your search to MEDLINE citationsadd medline[sb] to your search.

Indexing method

The method used to assign Medical Subject Headings (MeSH) has changed over time. For more informationplease see Incorporating Values for Indexing Method in MEDLINE/PubMed XML. Use the following searches to find citations indexed with each method:

• Automated - MeSH indexing is provided algorithmically. Search: indexingmethod_automated
• Curated - MeSH indexing is provided algorithmically and a human reviewed (and possibly modified) the algorithm results. Search: indexingmethod_curated
• Manual – MeSH indexing is provided by humans with no algorithmic suggestions. Search: indexingmethod_manual

PubMed Central (PMC)

PubMed Central (PMC) is a full text archive that includes articles from journals reviewed and selected by NLM for archiving (current and historical)as well as individual articles and preprints collected for archiving in compliance with funder policies. Some PMC content is not cited in PubMedsuch as book reviews and conference abstracts (see: PubMed coverage).

Preprints

As of June 2020PubMed Central (PMC) includes preprints that report NIH-funded research results. Citations to these preprints are deposited in PubMed. To learn moresee: NIH Preprint Pilot.

NCBI Bookshelf

Bookshelf is a full text archive of books reportsdatabasesand other documents related to biomedicalhealthand life sciences. PubMed includes citations for books and some individual chapters available on Bookshelf.

PubMed format

The PubMed Format tags table defines the data tags that compose the PubMed format. The tags are presented in alphabetical order. Some of the tags (e.g.CIN) are not mandatory and therefore will not be found in every record. Other tags (e.g.AUMHand RN) may occur multiple times in one record. You can download records in PubMed format as a text file (.txt) or as an .nbib file for exporting into citation management software programs.

Not all fields are searchable in PubMed. See Search field tags for the list of searchable fields.

PubMed data field descriptions

This documentation describes the fields found in PubMed records. If a field is searchable the search tag appears after the field name in square brackets: Affiliation [ad]. A small number of searchable fields do not correspond to a specific field in the PubMed format.

• See Search field tags for a list of searchable fields.
• See PubMed format for a quick table view of the fields found in PubMed records.

Affiliation [ad]

Affiliation may be included for authorscorporate authors and investigatorse.g., cleveland [ad] AND clinic [ad]if submitted by the publisher.

Multiple affiliations were added to citations starting from 2014previously only the first author’s affiliation was included. PubMed includes the note "Contributed equally" in the affiliation field when this information is supplied by publishers.

Searching for terms in the affiliation field searches in all author affiliations on a citation. For examplea search for Hopkins[ad] AND Bloomberg[ad] can find these terms spread across multiple authors’ affiliations on the same citation.

To search for multiple terms appearing within the same affiliationuse a proximity search. You can also search affiliations using a phrase search; howeverwe suggest using a proximity search for more comprehensive results because affiliation data may be provided in a variety of ways for the same institution.

All Fields [all]

Untagged terms and terms tagged with [all] are processed using Automatic Term Mapping (ATM). Terms that do not map are searched in all search fields except for Place of PublicationCreate Date, Completion DateEntry DateMeSH Dateand Modification Date. Terms enclosed in double quotes or including wildcards (*) will be searched in all fields and not processed using automatic term mapping. PubMed ignores stopwords.

Article Identifier [aid]

Includes article identifiers submitted by journal publishers such as DOI (digital object identifier).

Author [au]

The format to search for this field is: last name followed by a space and up to the first two initials followed by a space and a suffix abbreviationif applicableall without periods or a comma after the last name (e.g.fauci as or o'brien jc jr). Initials and suffixes may be omitted when searching.

PubMed automatically truncates a search for an author's name to account for varying initialse.g.o'brien j [au] will retrieve o'brien jao'brien jbo'brien jc jras well as o'brien j. To turn off automatic truncationenclose the author's name in double quotes and tag with [au] in bracketse.g."o'brien j" [au] to retrieve just o'brien j.

Searching by full author name for articles published from 2002 forward is also possible, if available. See NLM policy on author names.

Author Identifier [auid]

The author identifier includes a unique identifier associated with an authorcorporate or investigator nameif supplied by a publisher. The field includes the organization authority that established the unique identifiersuch asORCIDISNIVIAFe.g., orcid 0000-0001-5027-4446 [auid].

Book [book]

The book search field includes book citationse.g.genereviews [book].

Use the following untagged searches to retrieve all book or book chapterse.g.ataxia AND pmcbookchapter

• books and chapters: pmcbook
• books: pmcbooktitle
• book chapters: pmcbookchapter

The above searches capture book records provided by the NCBI Bookshelf database; they exclude a small number of documents from other providers that appear in both PubMed and Bookshelf. For the most comprehensive search of records appearing in both PubMed and Bookshelfsearch "pubmed books"[sb].

Comment Correction Type

The data in these fields are citations to other associated journal publicationse.g., comments or errata. Often these link to the respective citation. Comments/Corrections data can be retrieved by the search term that follows each type:

• Comment in: hascommentin
• Comment on: hascommenton
• Corrected and republished in: hascorrectedrepublishedin
• Corrected and republished from: hascorrectedrepublishedfrom
• Dataset use reported in: hasassociatedpublication
• Dataset described in: hasassociateddataset
• Erratum in: haserratumin
• Erratum for: haserratumfor
• Expression of concern in: hasexpressionofconcernin
• Expression of concern for: hasexpressionofconcernfor
• Original Report in: hasoriginalreportin
• Republished in: hasrepublishedin
• Republished from: hasrepublishedfrom
• Retracted and republished in: hasretractedandrepublishedin
• Retracted and republished from: hasretractedandrepublishedfrom
• Retraction in: hasretractionin
• Retraction of: hasretractionof
• Summary for patients in: hassummaryforpatientsin
• Update in: hasupdatein
• Update of: hasupdateof

Completion Date [dcom]

Used by NLM for internal processing. Completon Date is not included in All Fields retrieval; the [dcom] search tag is required.

Conflict of Interest Statement [cois]

The conflict of interest statement from the published article. Conflict of interest statements are available when supplied by the publisher in the citation data sent to PubMedor when included in full text articles in PubMed Central (PMC).

To retrieve all citations that contain conflict of interest statementsuse the query hascois.

Corporate Author [cn]

Corporate author identifies the corporate or collective authorship of an article. Corporate names display exactly as they appear in the journal.

Note: Citations indexed pre-2000 and some citations indexed in 2000-2001 retain corporate authors at the end of the title field. For comprehensive searchesconsider including terms and/or words searched in the title field [ti].

Create Date [crdt]

The date the citation record was first created in PubMed. Create Date can be helpful when checking PubMed for citations added since the last time a query was run. Create Date is not included in All Fields retrieval; the [crdt] search tag is required.

EC/RN Number [rn]

EC/RN numbers are assigned by:

• The Food and Drug Administration (FDA) Substance Registration System for Unique Ingredient Identifiers (UNIIs)e.g.Y92OUS2H9B
• The Enzyme Commission (EC) to designate a particular enzymee.g.EC 1.1.1.57
• The Chemical Abstracts Service (CAS) for Registry Numberse.g.2751-14-6

The EC/RN number search field includes both the Registry Number and the Related Registry Number (available in the NLM MeSH Browser).

Editor [ed]

The editor search field includes the editors for book or chapter citations.

Entry Date [edat]

Entry date (EDAT) is used for PubMed processingsuch as “Most Recent” sort order (i.e.last infirst out).

EDAT is typically set within 24 hours of the citation’s availability in PubMed. Exceptions: As of December 152008citations added to PubMed more than twelve months after the date of publication have the EDAT set to the date of publicationexcept for book citations. Prior to thisthe Entry Date was set to the Publication Date on citations published before September 1997. Entry Date is not included in All Fields retrieval; the [edat] search tag is required.

Note: Entry Date was called Entrez Date in the legacy PubMed system (retired in 2020).

Filter [filter] [sb]

Technical tags used by LinkOutfilters include:

• loall[sb] - citations with LinkOut links in PubMed
• free full text[sb] - citations that include a link to a free full text article
• full text[sb] - citations that include a link to a full text article

First Author Name [1au]

The first personal author name in a citation.

Full Author Name [fau]

The full author name for articles published from 2002 forwardif available. Full author searches can be entered in natural or inverted ordere.g.julia s wong or wong julia s.

Full Investigator Name [fir]

The index for the article's full investigator or collaborator nameif available. Full investigator searches can be entered in natural or inverted ordere.g.harry janes or janes harry.

Grants and Funding [gr]

The Grants and funding [gr] search field (previously Grant Number) includes grant numbers contract numbersor other intramural research identifiers associated with a publication.

The most common type of funding information associated with a publication in PubMed are grant numbers. Data in the Grants and funding search field can consist of up to four parts:

1. Number contains the grantcontractintramural project number (or both) that designates financial support by any agency of the United States Public Health Service (US PHS)any institute of the National Institutes of Healthor other organization.
2. Funder code contains the 2-letter grant code or funding organization acronymfor example: CA for National Cancer Institute or DDCF for Doris Duke Charitable Foundation. See Grant Number Information Found in the GR Field in MEDLINE/PubMed (Archived) for the 2-character abbreviationsPHS agency acronymsand other US and non-US funding organizations.
3. Agency includes the acronym or mnemonic in the case of US PHS agencies or full organization name. As of 2009 this includes the agency's hierarchical structure from lower to higher entitywhen known. For exampleNCI NIH HHS for National Cancer InstituteNational Institutes of HealthU.S. Department of Health and Human Services.
4. Country contains the home country of the funding agencyfor example: United States.

Each individual part can be searched using [gr]for example: CA101211[gr]CA[gr]NCI[gr] NIH[gr]or United States[gr].

This field can also be searched to find articles with intramural support; e.g. "intramural nih"[gr] finds all journal citations authored by intramural NIH staff.

Completeness of funding information in PubMed will vary by source.

See Grants and funding for more information about data in this field.

Investigator [ir]

Names of principal investigator(s) or collaborators who contributed to the research. Search names following the author field formatfor example: soller b[ir].

ISBN [isbn]

The ISBN for book or book chapters.

Issue [ip]

The number of the journal issue in which the article was published.

Journal [ta]

The journal search field includes the journal title abbreviationfull journal titleor ISSN/eISSN number (e.g.J Biol ChemJournal of Biological Chemistry0021-9258). If a journal title contains special characterse.g.parenthesesbracketsenter the name without these characterse.g.enter J Hand Surg [Am] as J Hand Surg Am.

Language [la]

The language search field includes the language in which the article was published. Note that many non-English articles have English language abstracts. You may search using either the language or the first three characters of most languagese.g.chi [la] retrieves the same results as chinese [la]. The most notable exception is jpn [la] for Japanese.

Last Author Name [lastau]

The last personal author name in a citation.

Location ID [lid]

Location ID includes the DOI or publisher ID that serves the role of pagination to locate an online article.

MeSH Date [mhda]

The date MeSH terms were added to the citation. MeSH Date is initially set to the Entry Date [EDAT] when the citation is added to PubMed; citations added to PubMed more than twelve months after the date of publication have EDAT and MHDA set to the date of publication.

MeSH Date is not included in All Fields retrieval; the [mhda] search tag is required.

Dates must be entered using the format YYYY/MM/DD [mhda]e.g.2000/03/15 [mhda]. The month and day are optional (e.g.2000 [mhda] or 2000/03 [mhda]).

To enter a date rangeinsert a colon (:) between each datee.g.1999:2000 [mhda] or 2000/03:2000/04 [mhda].

MeSH Major Topic [majr]

A MeSH term that is one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combinatione.g.Cytokines/physiology* See MeSH Terms [mh] below.

MeSH Subheadings [sh]

MeSH Subheadings are used with MeSH terms to help describe more completely a particular aspect of a subject. For examplethe drug therapy of asthma is displayed as asthma/drug therapy; see MeSH/Subheading Combinations in MeSH Terms [mh] below.

The MeSH Subheading field allows users to "free float" Subheadingse.g.hypertension [mh] AND toxicity [sh].

MeSH Subheadings automatically include the more specific Subheading terms under the term in a search. To turn off this automatic featureuse the search syntax [sh:noexp]e.g.therapy [sh:noexp].

In additionyou can enter the two-letter MeSH Subheading abbreviations rather than spelling out the Subheadinge.g.dh [sh] = diet therapy [sh].

MeSH Terms [mh]

The NLM Medical Subject Headings controlled vocabulary of biomedical terms that is used to describe the subject of each journal article in MEDLINE. MeSH is updated annually to reflect changes in medicine and medical terminology. MeSH terms are arranged hierarchically by subject categories with more specific terms arranged beneath broader terms. PubMed allows you to view this hierarchy and select terms for searching in the MeSH Database.

MEDLINE articles are automatically indexed with MeSH terms using a well-refined algorithm. Applying the MeSH vocabulary ensures that articles are uniformly indexed by subject whatever the author's words. For more informationsee Frequently Asked Questions about Indexing for MEDLINE.

More information about MeSH Terms and Major MeSH Topic search fields:

• To search the term only as a MeSH termit must be tagged using the search field, e.g.[mh] for MeSH Terms or [majr] for MeSH Major Topic. A tagged term is checked against the subject translation tableand then mapped to the appropriate MeSH term(s); entry terms tagged with [mh] also map to the appropriate MeSH term(s)increasing the access points to the citations since a searcher may not know the exact preferred term for a MeSH Descriptor. To search for the exact term only and turn off mapping to multiple MeSH termsenter the tagged MeSH term in double quotes.
• MeSH terms are arranged hierarchically by subject categories with more specific terms arranged beneath broader terms. MeSH terms in PubMed automatically include the more specific MeSH terms in a search. To turn off this automatic featureuse the search syntax [mh:noexp]e.g.neoplasms [mh:noexp].For more detailed information about MeSH vocabulary including the hierarchical structureplease see the MeSH homepage.
• MeSH/Subheading Combinations: To directly attach MeSH Subheadingsuse the format MeSH Term/Subheadinge.g.neoplasms/diet therapy. You may also use the two-letter MeSH Subheading abbreviationse.g., neoplasms/dh. The [mh] tag is not requiredhowever [majr] may be usede.g., plants/genetics[majr]. Only one Subheading may be directly attached to a MeSH term. For a MeSH/Subheading combinationPubMed always includes the more specific terms arranged beneath broader terms for the MeSH term and also includes the more specific terms arranged beneath broader Subheadings. The broader Subheadingor one of its indentionswill be directly attached to the MeSH term or one of its indentions. For examplehypertension/therapy also retrieves hypertension/diet therapy; hypertension/drug therapy; hypertension, malignant/therapy; hypertensionmalignant/drug therapyand so onas well as hypertension/therapy.
• To turn off the automatic inclusion of the more specific termsuse the syntax [field:noexp]e.g.hypertension [mh:noexp]or hypertension [majr:noexp]or hypertension/therapy [mh:noexp]. The latter example turns off the more specific terms in both partssearching for only the one Subheading therapy attached directly to only the one MeSH term hypertension.
• If parentheses are embedded in a MeSH termreplace the parentheses with a space and tag with [mh] e.g.enter the MeSH term Benzo(a)pyrene as benzo a pyrene [mh].
• MeSH terms can be selected for searching in the MeSH database and from the advanced search builder index.

Modification Date [lr]

Modification date is a completed citation’s most recent revision date. Modification Date is not included in All Fields retrieval; the [lr] search tag is required.

NLM Unique ID [jid]

The NLM ID is the alpha-numeric identifier for the cited journal that was assigned by the NLM Integrated Library System LocatorPluse.g.0375267 [jid].

Other Term [ot]

The author keyword field (OT field) is searchable with the title/abstract [tiab]text word [tw] and other term [ot] search tags. To retrieve all citations that have keywordsuse the query haskeyword. Other term data may display an asterisk to indicate a major concept; howeveryou cannot search other terms with a major concept tag.

Owner

The owner search field includes the acronym that identifies the organization that supplied the citation data. Search using owner + the owner acronyme.g.ownernasa.

Pagination [pg]

Enter only the first page number that the article appears on. The citation will display the full pagination of the article but this field is searchable using only the first page number.

Personal Name as Subject [ps]

Use this search field tag to limit retrieval to where the name is the subject of the articlee.g.varmus h[ps]. Search for personal names as subject using the author field formate.g.varmus h[ps].

Pharmacological Action [pa]

Substances known to have a particular pharmacologic action. Each pharmacologic action term index is created with the drug/substance terms known to have that effect. This includes both MeSH terms and terms for Supplementary Concept Records.

Place of Publication [pl]

Indicates the cited journal's country of publication. Geographic place of publication regions are not searchable. In order to retrieve records for all countries in a region (e.g.North America) it is necessary to OR together the countries of interest. Note: This field is not included in all fields or text word retrieval.

PMCID and MID

Search for PMC or NIH manuscript identifiers using the appropriate prefix followed by the ID numbere.g.PMC2600426. To retrieve all NIH manuscript citationsuse the query hasnihmsid.

PMID [pmid]

To search for a PubMed Identifier (PMID)enter the ID with or without the search field tag [pmid]. You can search for several PMIDs by entering each number in the search box separated by a space (e.g.17170002 16381840); PubMed will OR the PMIDs together. To search PMIDs in combination with other termsthe search field tag is required: lipman AND 16381840[pmid].

PMIDs do not change over time or during processing and are never reused.

Publication Date [dp]

Publication date is the date that the article was published. The search field tags [dp] and [pdat] may be used interchangeably for publication date searching.

Dates or date ranges must be searched using the format yyyy/mm/dd [dp]e.g.1998/03/06 [dp]. The month and day are optional (e.g.1998 [dp] or 1998/03 [dp]).

To enter a date range searchinsert a colon (:) between each datee.g.1996:1998 [dp] or 1998/01:1998/04 [dp].

Use the following format to search X daysmonths or years immediately preceding today’s date where X = numeric value:

• "last X days"[dp]
• "last X months"[dp]
• "last X year"[dp]

More information about publication dates:

• The time between an article’s publication and the citation’s availability in PubMed varies depending on when the publisher deposits the citation to PubMed. Because of this searching with Create Date [crdt] (the date a citation was created in PubMed) is often more comprehensive than Publication Date [dp] when checking PubMed on a regular basis for new citations.
• Journals vary in the way the publication date appears on an issue. Some journals include just the yearwhereas others include the year plus month or year plus month plus day. Andsome journals use the year and season (e.g.Winter 1997). The publication date in the citation is recorded as it appears in the journal.
• Publication dates without a month are set to Januarymultiple months (e.g., Oct-Dec) are set to the first monthand dates without a day are set to the first day of the month. Dates with a season are set as: winter = Januaryspring = April, summer = July and fall = October.
• If an article is published electronically and in print on different dates both dates are searchable and may be included on the citation prefaced with an Epub or Print label. Note: The electronic date is not included in a Publication Date [DP] search if the electronic date is later than the print date.
• To search for electronic dates only use the search tag [EPDAT]for print dates only tag with [PPDAT].
• Most journals now publish articles online on a continuous basisas soon as they are ready for publication (after peer review and editingetc.) instead ofor in addition topublishing collections of articles as an "issue" on a periodic basis. When a journal deposits a citation for an "online first" article in PubMedNLM appends the note "[Online ahead of print]" to the online publication date. The citation is updatedand the ahead of print notation removedwhen the article is included in a journal issue. The lag between the "online first" and "issue" publication dates may be daysweeksmonthsor more than a year. In many cases, depending on the journalthe online first version is considered to be the version of record. The "[Online ahead of print]" note in PubMed should not be taken to mean that the cited article is not the version of record.
• Bookshelf citation publication dates are generated from the book’s original publication date. Publication date searches include Contribution Date (CTDT) and Date Revised (DRDT) in addition to Publication Date (DP) for Book citations.

Publication Type [pt]

Describes the material presented in the article (e.g.ReviewClinical Trial, Retracted PublicationLetter). Citations may include multiple Publication Types. Use the search tag [pt] with any PubMed Publication Typee.g.review[pt].

Publication Types are arranged hierarchically with more specific terms arranged beneath broader termsand publication types automatically include the more specific publication types in a search.

• To turn off this automatic featureuse the search syntax [pt:noexp]e.g.review [pt:noexp].
• To view the publication type hierarchysee the Publication Formats: MeSH Tree Structures in the MeSH Browser.

Publisher [pubn]

Includes publisher names for Bookshelf citations.

Secondary Source ID [si]

The SI field identifies secondary source databanks and accession numberse.g.GenBank, GEOPubChemClinicalTrials.govISRCTN. The field is composed of the source followed by a slash followed by an accession number and can be searched with one or both componentse.g.genbank [si]AF001892 [si], genbank/AF001892 [si]. To retrieve all citations with an SI valuesearch hasdatabanklist.

Subset [sb]

The subset field is a method of restricting retrieval by subjectcitation status and journal categorywith the search tag [SB]. See also filters and Find related resources using LinkOut.

Supplementary Concept [nm]

Includes chemicalprotocoldisease or organism terms. Synonyms to the supplementary concepts will automatically map when tagged with [nm]. This field was implemented in mid-1980; howevermany chemical names are searchable as MeSH terms before that date.

Text Words [tw]

Includes all words and numbers in the titleabstractother abstractMeSH termsMeSH SubheadingsPublication TypesSubstance NamesPersonal Name as SubjectCorporate AuthorSecondary SourceComment/Correction Notesand Other Terms (see Other Term [OT] above) typically non-MeSH subject terms (keywords)including NASA Space Flight Mission, assigned by an organization other than NLM.

Title [ti]

Words and numbers included in the title of a citationas well as the collection title for book citations.

Title/Abstract [tiab]

Words and numbers included in a citation's titlecollection titleabstractother abstract and author keywords (Other Term [ot] field). English language abstracts are taken directly from the published article. If an article does not have a published abstractNLM does not create one.

Transliterated Title [tt]

Words and numbers in title originally published in a non-English languagein that language. Non-Roman alphabet language titles may be transliterated. Transliterated title is not included in Text Word [TW] retrieval.

Volume [vi]

The number of the journal volume in which an article is published.

NLM author indexing policy

NLM author indexing policy is as follows:

• 1966 - 1984: MEDLINE did not limit the number of authors.
• 1984 - 1995: The NLM limited the number of authors to 10with "et al" as the eleventh occurrence.
• 1996 - 1999: The NLM increased the limit from 10 to 25. If there were more than 25 authorsthe first 24 were listedthe last author was used as the 25thand the twenty-sixth and beyond became "et al."
• 2000 - Present: MEDLINE does not limit the number of authors.

More information:

• Beginning in mid-2005the policy restrictions on number of author names in past years were lifted so that on an individual basisa citation may be edited to include all author names in the published articleregardless of the limitation in effect when the citation was created.
• Effective with 1992 date of publicationletters are indexed individually with authors rather than as an anonymous group.
• Until 1990NLM transliterated up to five authors' Cyrillic or Japanese names to the Roman alphabet.
• Between 1990 and 2016the first ten Cyrillic or Japanese names are transliterated. Chinese ideograms were not transliterated by NLMbut if transliterations of the authors names are available in the journal article or table of contentsthey were included in the citationeven if that includes only one author in a multi-author article.
• Beginning in 2016author names are published in Roman characters in all MEDLINE journalsand NLM no longer transliterates Cyrillic or Japanese names. All author names are included as published.

Error messages

System error messages

Please provide your IT staff with the technical browser advice for NCBI web pages to ensure your browserfirewalland servers are enabled for JavaScript, cookiespop-upsand HTTP 1.1. Antivirus software may affect page caching which can result in unexpected page expired messages. Alsonlm.nih.gov should be added as a browser exception and be considered a trusted site by your system and network. You may have to delete your browser's cache (temporary files) before trying to access PubMed again.

Typographical errors

Please contact the journal publisher directly to report an error and initiate a correction to PubMed citations for content other than MeSH.

To report a MeSH error in a PubMed citationplease contact the NLM Help Desk and include the PMID number (e.g.PMID: 12345678)and an indication of the incorrect and correct information.

NLM provides data to vendors around the world. Other products and services will not necessarily immediately reflect corrections made to PubMed records. If you search through a vendor's systemplease contact your vendor about their maintenance schedules.

Cookies

A "cookie" is information stored by a web site server on your computer. See the NLM Privacy Policy for additional information.

In the case of PubMedcookies store information about your interactions that may be needed later to perform a function. To use these interactive features you need to enable cookies on your computer. Consult your browser's help for information on enabling cookies.

If you have problems using cookie-dependent features of PubMedeven after enabling cookiespossible reasons may include:

• Cookies are blocked by your provider or institution. Check with your Internet provider and/or the system administrator at your institution to see if cookies can be accepted. Even if you have them enabled in your web browserif they are blocked by your provider or institution (e.g.by a firewallproxy serveretc.), cookie-dependent features of PubMed won't work.
• Your computer's date and time settings are incorrect. Check your computer's time settings to ensure that they are correct.

MeSH Subheadings

See the MeSH Subheadings table below and scope notes and allowable categories on the NLM website.

Stopwords

PubMed character conversions

Certain characters have special meaning in searchesothers are converted to spaces.

Searches that include the following characters are translated as follows:

• parentheses ( ) - used to create Boolean nesting
• square brackets [ ] - search field tag qualification
• ampersand & - Boolean operator AND
• pipe | - Boolean operator OR
• forward slash / - MeSH/Subheading combinations
• colon : - designates a range operation
• double quotes " - used to force a phrase search
• pound sign # - designates a History search statement when immediately followed by a numbere.g.#1 AND cat
• asterisk * - wildcard symbole.g.toxicol*

Characters converted to spaces in search queries:

• exclamation mark !
• pound sign #
• dollar sign $
• percentage sign %
• asterisk * (if it cannot be used in a wildcard searchfor examplewhen a term is too short)
• plus symbol +
• minus symbol -
• period .
• comma ,
• semi-colon ;
• angle brackets < >
• equal sign =
• question mark ?
• backslash \
• caret ^
• underscore _
• curly brackets { }
• approximately ~
• single quotes '

Some characters have special meaning in MeSH fields:

• forward slash /
• hypens -
• comma ,

Publication Types

Publication types found in PubMed are listed below. See Publication Type [PT] and MeSH Publication Types with Scope Notes for more information; howevernot all MeSH Publication Types are included in PubMed.

Discontinued Publication Types are marked in the list below with an asterisk (*). Discontinued Publication Types continue to exist in MeSHappear on existing citationsand are searchable in PubMed; howeverthey are not applied to new citations during MEDLINE indexing.

• Adaptive Clinical Trial
• Address
• Autobiography *
• Bibliography *
• Biography
• Case Reports
• Clinical Conference *
• Clinical Study
• Clinical Trial
• Clinical TrialPhase I
• Clinical TrialPhase II
• Clinical TrialPhase III
• Clinical TrialPhase IV
• Clinical Trial Protocol
• Clinical TrialVeterinary
• Collected Work
• Comment
• Comparative Study
• Conference Proceedings
• Consensus Statement
• Consensus Development ConferenceNIH *
• Controlled Clinical Trial
• Corrected and Republished Article
• Dataset
• Dictionary *
• Directory *
• Duplicate Publication
• Editorial
• Electronic Supplementary Materials
• English Abstract
• Equivalence Trial
• Evaluation Study
• Evidence Synthesis
• Expression of Concern
• Festschrift
• Government Publication *
• Guideline
• Historical Article
• Interactive Tutorial *
• Interview
• Introductory Journal Article
• Journal Article (Default value when no more descriptive PT is provided or assigned)
• Lecture
• Legal Case *
• Legislation *
• Letter
• Meta-Analysis
• Multicenter Study
• Network Meta-Analysis
• News
• Newspaper Article *
• Observational Study
• Observational StudyVeterinary
• Overall *
• Patient Education Handout
• Periodical Index *
• Personal Narrative
• Portrait *
• Practice Guideline
• Preprint
• Pragmatic Clinical Trial
• Published Erratum
• Randomized Controlled Trial
• Randomized Controlled TrialVeterinary
• Research SupportAmerican Recovery and Reinvestment Act
• Research SupportN.I.H.Extramural
• Research SupportN.I.H.Intramural
• Research SupportNon-U.S. Gov't
• Research SupportU.S. Gov'tNon-P.H.S.
• Research SupportU.S. Gov'tP.H.S.
• Retracted Publication
• Retraction Notice
• Review
• Scientific Integrity Review *
• Scoping Review
• Seminal Article *
• Systematic Review
• Technical Report *
• Twin Study
• Validation Study
• Video-Audio Media
• Webcast

Status Subsets

Filter search strategies

• Publication date
• Text availability
• Article attribute
• Article type
• Article language
• Species
• Sex
• Age
• Other

Publication date

Text availability

Article attribute

Article type

Most article type filters use the article type name with the publication type [pt] search field tag; for example"multicenter study"[pt].

The Systematic Review filter uses a search strategy in addition to the publication type [pt].

The Books and Documents filter uses the following query: "pubmed books"[sb].

Article language

The article language filters use the language name with the language [la] search field tag; for exampleesperanto[la].

Species

Sex

Age

Other

See Other filters and more subsets.

Clinical Queries filters

• COVID-19 Articles
• Clinical Study Categories
• Medical Genetics

COVID-19 article filters

The COVID-19 article filters limit retrieval to citations about the 2019 novel coronavirus; these filters may evolve over time.

Clinical Study Categories

The Clinical Study Categories search filters are based on the work of Haynes RB et al.

Clinical Study Categories bibliography

The Clinical Queries search strategies have been updated based on new evidence from Haynes et al. The current strategies have better performance than their predecessors. Details of methods appear in the references below.

Revised December 2011

• Wilczynski NLMcKibbon KAHaynes RB. Sensitive Clinical Queries retrieved relevant systematic reviews as well as primary studies: an analytic survey. J Clin Epidemiol. 2011 Dec;64(12):1341-9. doi: 10.1016/j.jclinepi.2011.04.007. Epub 2011 Jul 19. PMID: 21775104.
• Lokker CHaynes RBWilczynski NLMcKibbon KAWalter SD. Retrieval of diagnostic and treatment studies for clinical use through PubMed and PubMed's Clinical Queries filters. J Am Med Inform Assoc. 2011 Sep-Oct;18(5):652-9. doi: 10.1136/amiajnl-2011-000233. Epub 2011 Jun 15. PMID: 21680559; PMCID: PMC3168323.
• Wilczynski NLHaynes RB; QI Hedges Team. Optimal search filters for detecting quality improvement studies in Medline. Qual Saf Health Care. 2010 Dec;19(6):e31. doi: 10.1136/qshc.2010.042432. Epub 2010 Jul 29. PMID: 20671080.
• Kastner MWilczynski NLMcKibbon AKGarg AXHaynes RB. Diagnostic test systematic reviews: bibliographic search filters ("Clinical Queries") for diagnostic accuracy studies perform well. J Clin Epidemiol. 2009 Sep;62(9):974-81. doi: 10.1016/j.jclinepi.2008.11.006. Epub 2009 Feb 20. PMID: 19230607; PMCID: PMC2737707.
• Wilczynski NLHaynes RB. Response to Corrao et al.: Improving efficacy of PubMed clinical queries for retrieving scientifically strong studies on treatment. J Am Med Inform Assoc. 2007 Mar-Apr;14(2):247-8. Epub 2007 Jan 9. PMID: 17213490; PMCID: PMC2213472.
• Wilczynski NLMcKibbon KAHaynes RB. Response to Glanville et al.: How to identify randomized controlled trials in MEDLINE: ten years on. J Med Libr Assoc. 2007 Apr;95(2):117-8; author reply 119-20. PMID: 17443240; PMCID: PMC1852612.
• Wilczynski NLMorgan DHaynes RB; Hedges Team. An overview of the design and methods for retrieving high-quality studies for clinical care. BMC Med Inform Decis Mak. 2005 Jun 21;5:20. doi: 10.1186/1472-6947-5-20. PMID: 15969765; PMCID: PMC1183213.
• Haynes RBMcKibbon KAWilczynski NLWalter SDWerre SR; Hedges Team. Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ. 2005 May 21;330(7501):1179. doi: 10.1136/bmj.38446.498542.8F. Epub 2005 May 13. PMID: 15894554; PMCID: PMC558012.
• Montori VMWilczynski NLMorgan DHaynes RB; Hedges Team. Optimal search strategies for retrieving systematic reviews from Medline: analytical survey. BMJ. 2005 Jan 8;330(7482):68. doi: 10.1136/bmj.38336.804167.47. Epub 2004 Dec 24. PMID: 15619601; PMCID: PMC543864.
• Wilczynski NLHaynes RBLavis JNRamkissoonsingh RArnold-Oatley AE; HSR Hedges team. Optimal search strategies for detecting health services research studies in MEDLINE. CMAJ. 2004 Nov 9;171(10):1179-85. doi: 10.1503/cmaj.1040512. PMID: 15534310; PMCID: PMC524948.
• Wilczynski NLHaynes RB; Hedges Team. Developing optimal search strategies for detecting clinically sound prognostic studies in MEDLINE: an analytic survey. BMC Med. 2004 Jun 9;2:23. doi: 10.1186/1741-7015-2-23. PMID: 15189561; PMCID: PMC441418.
• Haynes RBWilczynski NL. Optimal search strategies for retrieving scientifically strong studies of diagnosis from Medline: analytical survey. BMJ. 2004 May 1;328(7447):1040. doi: 10.1136/bmj.38068.557998.EE. Epub 2004 Apr 8. PMID: 15073027; PMCID: PMC403841.
• Bhandari MMontori VMDevereaux PJWilczynski NLMorgan DHaynes RB; Hedges Team. Doubling the impact: publication of systematic review articles in orthopaedic journals. J Bone Joint Surg Am. 2004 May;86(5):1012-6. PMID: 15118046.
• Wong SSWilczynski NLHaynes RB; Hedges Team. Developing optimal search strategies for detecting clinically relevant qualitative studies in MEDLINE. Stud Health Technol Inform. 2004;107(Pt 1):311-6. PMID: 15360825.
• Montori VMWilczynski NLMorgan DHaynes RB; Hedges Team. Systematic reviews: a cross-sectional study of location and citation counts. BMC Med. 2003 Nov 24;1:2. doi: 10.1186/1741-7015-1-2. PMID: 14633274; PMCID: PMC281591.
• Wong SSWilczynski NLHaynes RBRamkissoonsingh R; Hedges Team. Developing optimal search strategies for detecting sound clinical prediction studies in MEDLINE. AMIA Annu Symp Proc. 2003;2003:728-32. PMID: 14728269; PMCID: PMC1479983.
• Wilczynski NLHaynes RB; Hedges Team. Developing optimal search strategies for detecting clinically sound causation studies in MEDLINE. AMIA Annu Symp Proc. 2003;2003:719-23. PMID: 14728267; PMCID: PMC1480286.
• Wilczynski NLMcKibbon KAHaynes RB. Enhancing retrieval of best evidence for health care from bibliographic databases: calibration of the hand search of the literature. Stud Health Technol Inform. 2001;84(Pt 1):390-3. PMID: 11604770.
• Haynes RBWilczynski NMcKibbon KAWalker CJSinclair JC. Developing optimal search strategies for detecting clinically sound studies in MEDLINE. J Am Med Inform Assoc. 1994 Nov-Dec;1(6):447-58. doi: 10.1136/jamia.1994.95153434. PMID: 7850570; PMCID: PMC116228.

Medical genetics search filters

The medical genetics searches were developed in conjunction with the staff of GeneReviews: Genetic Disease Online Reviews at GeneTestsUniversity of WashingtonSeattle.

Computation of similar articles

The neighbors of a document are those documents in the database that are the most similar to it. The similarity between documents is measured by the words they have in commonwith some adjustment for document lengths. To carry out such a programone must first define what a word is. For usa word is basically an unbroken string of letters and numerals with at least one letter of the alphabet in it. Words end at hyphens, spacesnew linesand punctuation. The 132 commonbut uninformativewords (also known as stopwords) are eliminated from processing at this stage. Nexta limited amount of stemming of words is donebut no thesaurus is used in processing. Words from the abstract of a document are classified as text words. Words from titles are also classified as text wordsbut words from titles are added in a second time to give them a small advantage in the local weighting scheme. MeSH terms are placed in a third categoryand a MeSH term with a subheading qualifier is entered twiceonce without the qualifier and once with it. If a MeSH term is starred (indicating a major concept in a document)the star is ignored. These three categories of words (or phrases in the case of MeSH) comprise the representation of a document. No other fieldssuch as Author or Journalenter into the calculations.

Having obtained the set of terms that represent each documentthe next step is to recognize that not all words are of equal value. Each time a word is usedit is assigned a numerical weight. This numerical weight is based on information that the computer can obtain by automatic processing. Automatic processing is important because the number of different terms that have to be assigned weights is close to two million for this system. The weight or value of a term is dependent on three types of information: 1) the number of different documents in the database that contain the term; 2) the number of times the term occurs in a particular document; and 3) the number of term occurrences in the document. The first of these pieces of information is used to produce a number called the global weight of the term. The global weight is used in weighting the term throughout the database. The second and third pieces of information pertain only to a particular document and are used to produce a number called the local weight of the term in that specific document. When a word occurs in two documentsits weight is computed as the product of the global weight times the two local weights (one pertaining to each of the documents).

The global weight of a term is greater for the less frequent terms. This is reasonable because the presence of a term that occurred in most of the documents would really tell one very little about a document. On the other handa term that occurred in only 100 documents of one million would be very helpful in limiting the set of documents of interest. A word that occurred in only 10 documents is likely to be even more informative and will receive an even higher weight.

The local weight of a term is the measure of its importance in a particular document. Generallythe more frequent a term is within a documentthe more important it is in representing the content of that document. Howeverthis relationship is saturating, i.e.as the frequency continues to go upthe importance of the word increases less rapidly and finally comes to a finite limit. In additionwe do not want a longer document to be considered more important just because it is longer; thereforea length correction is applied. This local weight computation is based on the Poisson distribution and the formula can be found in Lin J and Wilbur WJ.

The similarity between two documents is computed by adding up the weights (local wt1 × local wt2 × global wt) of all of the terms the two documents have in common. This provides an indication of how related two documents are. The resultant score is an example of a vector score. Vector scoring was originated by Gerard Salton and has a long history in text retrieval. The interested reader is referred to SaltonAutomatic Text ProcessingReadingMA: Addison-Wesley1989 for further information on this topic. Our approach differs from other approaches in the way we calculate the local weights for the individual terms. Once the similarity score of a document in relation to each of the other documents in the database has been computedthat document's neighbors are identified as the most similar (highest scoring) documents found. These closely related documents are pre-computed for each document in PubMed so that when you select Similar articlesthe system has only to retrieve this list. This enables a fast response time for such queries.

Journal lists

PubMed journals

• Uncompressed
• GNU zip
• UNIX Compress
• PKZIP

PubMed and NCBI molecular biology database journals

• Uncompressed
• GNU zip
• UNIX Compress
• PKZIP