×

注意！页面内容来自https://pubmed.ncbi.nlm.nih.gov/40570836/，本站不储存任何内容，为了更好的阅读体验进行在线解析，若有广告出现，请及时反馈。若您觉得侵犯了您的利益，请通知我们进行删除，然后访问 原网页

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive informationmake sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Sep 18;188(19):5403-5425.e33.
doi: 10.1016/j.cell.2025.06.001. Epub 2025 Jun 25.

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

Lingling Geng  1 , Jiale Ping  2 , Ruochen Wu  3 , Haoteng Yan  1 , Hui Zhang  4 , Yuan Zhuang  5 , Taixin Ning  1 , Jun Wang  6 , Chuqian Liang  3 , Jiachen Zhang  1 , Qingqing Chu  4 , Jing Zhang  1 , Yifan Wen  3 , Yaobin Jing  7 , Shuhui Sun  4 , Qin Qiao  8 , Qian Zhao  1 , Qianzhao Ji  9 , Shuai Ma  10 , Yusheng Cai  9 , Yandong Zheng  11 , Zhiran Zou  3 , Zhiqing Diao  3 , Mingheng Li  3 , Hao Zhang  3 , Jianli Hu  2 , Liangzheng Fu  3 , Wang Kang  2 , Ruijun Bai  12 , Hongkai Zhao  3 , Sheng Zhang  3 , Yingjie Ding  2 , Jinghui Lei  1 , Wei Wang  3 , Yun Ji  3 , Bo Gou  3 , Guoqiang Sun  3 , Jian Yin  3 , Pengze Yan  3 , Hao Li  2 , Zehua Wang  3 , Shikun Ma  12 , Zunpeng Liu  3 , Hezhen Shan  12 , Qiaoran Wang  2 , Tianling Cao  3 , Shanshan Yang  1 , Cui Wang  2 , Ping Yang  3 , Yanling Fan  8 , Yanxia Ye  9 , Jinghao Hu  1 , Mengmeng Jiang  9 , Ye Wang  13 , Kan Liu  13 , Yujing Li  3 , Yuanxiang Li  3 , Jingyi Li  14 , Weimin Ci  13 , Zi-Bing Jin  15 , Xiaobing Fu  16 , Xu Zhang  13 , Guoguang Zhao  17 , Juan Carlos Izpisua Belmonte  18 , Si Wang  19 , Moshi Song  20 , Weiqi Zhang  21 , Jing Qu  22 , Guang-Hui Liu  23
Affiliations

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

Lingling Geng et al. Cell. .

Erratum in

  • Systematic profiling reveals betaine as an exercise mimetic for geroprotection.
    Geng LPing JWu RYan HZhang HZhuang YNing TWang JLiang CZhang JChu QZhang JWen YJing YSun SQiao QZhao QJi QMa SCai YZheng YZou ZDiao ZLi MZhang HHu JFu LKang WBai RZhao HZhang SDing YLei JWang WJi YGou BSun GYin JYan PLi HWang ZMa SLiu ZShan HWang QCao TYang SWang CYang PFan YYe YHu JJiang MWang YLiu KLi YLi YLi JCi WJin ZBFu XZhang XZhao GIzpisua Belmonte JCWang SSong MZhang WQu JLiu GH. Geng Let al. Cell. 2025 Sep 18;188(19):5426-5428. doi: 10.1016/j.cell.2025.07.030. Epub 2025 Aug 12. Cell. 2025. PMID: 40803320 No abstract available.

Abstract

Exercise has well-established health benefitsyet its molecular underpinnings remain incompletely understood. We conducted an integrated multi-omics analysis to compare the effects of acute vs. long-term exercise in healthy males. Acute exercise induced transient responseswhereas repeated exercise triggered adaptive changesnotably reducing cellular senescence and inflammation and enhancing betaine metabolism. Exercise-driven betaine enrichmentpartly mediated by renal biosynthesisexerts geroprotective effects and rescues age-related health decline in mice. Betaine binds to and inhibits TANK-binding kinase 1 (TBK1)retarding the kinetics of aging. These findings systematically elucidate the molecular benefits of exercise and position betaine as an exercise mimetic for healthy aging.

Keywords: ETS1; TBK1; aging; betaine; exercise; exercise immunology; exercise metabolism; inflammation; kidney; senescence.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests J.C.I.B. is an employee of Altos Labs.

LinkOut - more resources