Depressive Episode

The definition of a depressive episode is a period of depression that persists for at least two weeks. 1 During a depressive episodea person will typically experience low or depressed mood and/or loss of interest in most activitiesas well as a number of other symptoms of depressionsuch as tirednesschanges in appetitefeelings of worthlessnessand recurrent thoughts of death. The length of a depressive episode variesbut the average duration is thought to be six to eight months. 2

Depression is a common illnessand many people will experience one or more episodes of depression in their lifetime. While people of all races and ages can experience depressive episodesthey tend to be more common among women than men. 3 4 People who have a history of depressionother mental health conditions such as bipolar disorder or anxietyor chronic physical conditions such as diabeteschronic pain or multiple sclerosis 5also have a higher risk of experiencing a depressive episode. 2

The severity of a depressive episode varies; it may be classified as major or minordepending on the number of symptoms and degree of impairment (socialdomesticand work) experienced. Regardless of the severityall depressive episodes should be taken seriously and treated promptly by a professional healthcare provider. Effective treatmentwhich typically involves medication and/or therapyfor depression is available. 4

Without appropriate treatmentthe risk of experiencing further episodes of depression is thought to be higher. The risk of another depressive episode occurring seems to increase with every new episodewith each one likely to last longer and be more severe than the previous one. Timely treatment can alleviate the symptoms of depression and help shorten the duration of any future episodes. 6

The symptoms of a depressive episode typically include a depressed moodi.e. feeling sademptyor hopelessand/or loss of interest or enjoyment in most activitiestogether with any number of the following: 1 7

• Feeling worthless or excessively guilty
• Fatigue or lethargy
• Difficulty with concentrationmemoryand decision-making
• Insomnia is not being able to sleep through the nightwaking up earlyor sleeping too much
• Appetite changes
• Unexplained weight loss or gain
• Unexplained physical ailments that do not respond to treatmentsuch as headachesdigestive problemsor pain
• Sluggishnessrestlessnessagitationor irritability
• Thoughts of death or suicidesometimes with suicide plans or suicide attempts

These symptoms are usually present every day or almost every dayfor at least two weeks. 1

Signs of depression may differ according to sex and age. There are also various types of depression and depressive disordersincluding major depressionbipolar disorder (previously known as manic depression)postpartum depression and dysthymiaamong others. 8

If a person seems to be in imminent danger of harming themselvesan emergency support provider should be contacted immediately.

The causes of depressive episodes are complex and variedinvolving socialpsychological and biological factors. Depression may occur as an isolated episode or as part of a chronic depressive condition. 4 While the exact causes are not yet fully understoodthe following may increase a person’s likelihood of experiencing a depressive episode: 2 3 ref7 9 10

• History of depressive episodes
• Bipolar disorder
• Anxiety
• Attention-deficit hyperactivity disorder (ADHD)
• Other mental health conditions
• Family history of depression
• Changes in the functioning of the brain
• History of sleep problems
• Chronic pain
• Heart diseasecancer and other chronic health conditions
• Stressful life events such as losing one’s joblosing a loved one (bereavement) or psychological trauma
• Lack of personal support structures
• Drug and alcohol abuse
• Childhood trauma

People who have recently had a baby may experience postpartum depression. 11

Sometimesthere is no obvious cause for the occurence of a depressive episode. 10

Some health conditionssuch as hypothyroidismcan cause symptoms of depression. 3 While uncommonadverse reactions to certain medications can also cause depressed mood. 2 Howevertreating these underlying causes and disorders should alleviate the symptoms.

After taking the affected person’s medical history and performing a physical examinationa doctor or the mental health specialist to which the person is referred tocan diagnose a depressive episode based on the criteria set out in the Diagnostic and Statistical Manual of Mental DisordersFifth Edition (DSM-5).

A major depressive episode (MDE) is characterized by five or more of the following symptoms being present every dayor almost every dayfor a minimum of two weeks: 1

• Depressed mood for most of the day
• Loss of interest or enjoyment in all or most activities
• Significant unexplained weight loss or gainor appetite changes
• Sleep disturbancesincluding insomnia or sleeping too much (hypersomnia)
• Restlessness or sluggishness
• Tiredness or lack of energy
• Feelings of worthlessness or excessive guilt
• Difficulty thinkingconcentrating or making decisions
• Thoughts of death or suicide – there may be suicide plans or suicide attempts

These symptoms should indicate a marked difference from the affected person’s previous functioning. For the diagnosis to be madeat least one of the symptoms needs to be depressed mood or loss of interest in most activities. It is also necessary for the symptoms to cause significant distress or impairment in social and job functioning. 1

If the symptoms are attributed to another mental health conditionthe diagnosis and treatment may be different to that detailed here for a depressive episode. 1

To rule out any other health conditions that could be causing symptoms of a depressive statesuch as a thyroid disordera doctor may order blood tests or scans. If a person is considered to be at risk of dementiathe doctor will also check for this conditionas some of the symptoms can be similar to depression. 2

If only two to four of the above symptoms are presentinstead of a major depressive episodea diagnosis of a minor depressive episode may be made. At least one of the symptoms needs to be a depressed mood or loss of interest in most activities. This may occur as part of a minor depressive disorder.

Depression is considered to be a treatable conditionwith treatment often involving a combination of medication and therapy. Sometimes complementary remedies and life changes may also be suggested. The treatment program will be tailored according to the severity of the depressive episodeas well as the affected person’s medical history and personal preferences. 2 3 11

Psychotherapy is talk therapyand there are several different types that may be effective for people experiencing a mild or moderate depressive episode. These include counselingproblem-solving therapyinterpersonal therapygroup therapyand cognitive behavioral therapy (CBT) – which can help a person develop more helpful ways of thinking and acting. 10 12

For some peoplea combination of psychotherapy and medication may be more effective than psychotherapy alone for depression. 12

Medication may be prescribed in cases of moderate or severe depressionoften in combination with a course of psychotherapy. 2 While the way it works is not yet fully understoodantidepressant medication may alter the levels of neurotransmitters in the brain with a positive impact on mood. 10 12

Several different types of antidepressants are available. The main categories include: 12 13

• Selective serotonin reuptake inhibitors (SSRIs): Typically the first line of treatment2 SSRIs tend to cause fewer side-effects than other antidepressants. Examples of SSRIs include fluoxetineparoxetineand sertraline.
• Serotonin and norepinephrine reuptake inhibitors (SNRIs): Similar to SSRIsbut may work better for some people. Examples include venlafaxine and duloxetine.
• Tricyclic antidepressants (TCAs): An older type of medication that may cause more side effects. Generally only prescribed if other treatments do not workor for other mental health conditions. Examples of TCAs include amitriptyline and imipramine.
• Monoamine oxidase inhibitors (MAOIs): A type of antidepressant usually prescribed when other treatments have not worked or have caused intolerable side effectsas well as in cases of atypical depressionwhich has different characteristics to other types of depression. Examples include phenelzine and isocarboxazid. Because MAOIs can interact with certain foods and medicationsspecial care must be taken with this antidepressant. 14

There are also a few other types of antidepressantssuch as bupropion and mirtazapine.

It may take a few weeks for an antidepressant to take effect and alleviate the symptoms of a depressive episode. A doctor will advise on how long the medication should be taken and what to do if a person wishes to stop taking it. While antidepressants are not considered to be addictivestopping them suddenly may cause discontinuation symptoms, so the process needs to be managed by a medical practitioner. 12

Some people may experience side effects while taking antidepressantsincluding: 12

• Nausea and vomiting
• Weight gain
• Diarrhea or constipation
• Feeling sleepy
• Sexual problems

While less commonother side-effects may include serotonin syndromea potentially life-threatening condition where high levels of serotonin cause mental and physical symptoms like anxietyrapid heartbeathigh temperature and vomiting15 and suicidal thoughts. 12

It may be necessary for a person to try several different medications before finding one that they feel works for them. 12 The type of antidepressants prescribed will depend on the affected person’s agehealthand medical history. A doctor will arrange check-ups a couple of weeks after treatment is started and regularly thereafter to monitor progress. 2

Exercise: Physical activity may be recommended to help with mild to moderate depressionthough it is not entirely clear how effective exercise is. 2 3

St John’s Wort: This herbal medicine is sometimes recommended for depressive episodes. Howeverits efficacy has not been conclusively provenand it may interact with prescription medications. Before taking St John’s Wortit is advisable to consult a doctor even if taking no other medicationsbut especially if taking other prescription or over-the-counter medication. 10 12

Electroconvulsive therapy (ECT): In this treatmentan electrical current is used to stimulate the brain. ECT is typically reserved for depression that is particularly severe or has not responded to other treatments. 10

Light therapy: Bright light therapy has been shown to improve depressive symptomsboth as part of seasonal affective disorder (SAD) and non-seasonal major depressive disorder. Light therapy may be helpful on its own or in combination with psychotherapy or antidepressant medication. 16

Acupuncturespiritual practiceand nutritional changes may also be suggested as complementary therapies to help in the treatment of depressive episodesthough there is insufficient scientific evidence to support their efficacy. 3

If the depressive episode is milda doctor may suggest waiting for two weeks to see if it clears on its own. In additionthey may recommend self-help resourcesrelaxation therapiesand a small number of psychotherapy sessions. Antidepressants are not usually prescribed for mild depression unless they persist or cause complications. 2 11

In severe cases of depressionwhere a person is at risk of harming themselves or others or is experiencing psychotic symptomsthey may be referred to a specialist care facility. 2

If a person seems in imminent danger of harming themselvesan emergency support provider should be contacted immediately.

Speaking to a healthcare professional and following the treatment program they recommend is very important in managing depressive episodes.

While there is no known way to prevent a depressive episodecertain positive behaviors may be helpful. These include: 10

• Talking about feelings when upset
• Staying activee.g. exercising and getting outdoors
• Eating a balanced diet
• Avoiding alcohol and drugs
• Writing down factors that may be causing the depression and trying to find solutions

• Major Depression
• Depression
• Mild Depression
• Dysthymia
• Chronic depression
• Dysthymic Disorder
• Neurotic depression
• Persistent depressive disorder
• Affective disorder
• Mood disorder

Q: I feel a depressive episode coming on. What can I do to stop it?
A: If you think that you are about to experience a depression flare-upit is recommended that you speak to a psychotherapist or other qualified healthcare professional. If this is not possiblean online or over-the-phone counseling service may be helpful. See numbers for mental health helplines in the UK and USA and crisis lines in other countries. There is currently no known way to prevent a depressive “attack”but therapy and/or antidepressant medication may help to manage it. In additionpracticing self-care is recommended. This includes talking about your feelings if you are upsetgetting regular exercisegetting outdoorseating a balanced dietand avoiding alcohol and other intoxicating substances.

Q: How long does a depressive episode last?
A: The duration of a depressive episode varies and is influenced by its severityas well as treatment and individual factors. Howeverthe average length of a depressive episode is thought to be six to eight months. 2

Q: What should I do during a depressive episode?
A: When depression “hits”many people wonder what they can do to get out of the depressed state. There is no quick remedy for a depressive episodebut it is important to remember that you can take steps to manage itbeginning by speaking to a doctor or psychotherapistand/or taking antidepressant medication. In additionpracticing self-care strategies like getting exerciseeating healthilyand avoiding alcohol and drugs is recommended.

Q: If a loved one is experiencing a depressive episodewhat is the best thing to do?
A: If a friend or partner shows signs of being depressedthe following behaviors may be helpful: 10

• Listening without judgment
• Spending time with the person
• Reassuring them that they can get better
• Helping them to eat a balanced diet
• Helping them get outside and movinge.g. by taking them on regular walks or supporting them in exercising
• Helping them to avoid alcohol
• Encouraging them to speak to a healthcare professional
• Encouraging them to adhere to their treatment program

It is important to understand that it may take a person experiencing depression a long time to get better. The support of familyfriends and broader social networks is an important part of recovery.